Endocrine Abstracts

Cushing’s syndrome (CS) remains a diagnostic challenge due to an overlap with other clinical conditions such as pseudo-Cushing, which can be triggered by major depression, alcoholism, and metabolic syndrome. The most prevalent cause of CS is iatrogenic. When Cushing’s syndrome is caused by endogenous cortisol secretion, most often an ACTH-secreting pituitary adenoma is the culprit and the syndrome is hence referred to as Cushing’s disease. In very rare cases CS ...

The two primary functions of the adult testis (sperm production and hormone production) need to be co-ordinated because sperm production is completely dependent on appropriate hormone (primarily testosterone) production. However, it is equally evident from animal studies that Leydig cell (LC) development and function are also affected by developmental and functional status of the seminiferous tubules. For example, development of the adult LC population is dependent on reduced ...

Berardinelli-Seip syndrome is an autosomal recessive disorder characterized by generalized lipoatrophy, extreme insulin resistance with dyslipidaemia in childhood and development of diabetes and hepatic steatosis in adolescence. The metabolic derangements can be severe and lead to substantial comorbidities, including acute pancreatitis, hepatic cirrhosis, and premature cardiovascular disease. Other manifestations can include polycystic ovarian syndrome, acanthosis nigricans, a...

Obesity is the single most significant risk factor for testosterone deficiency in men, with a reported prevalence up of 60% of male obesity secondary hypogonadism (MOSH). Several studies have shown that significant weight loss due to bariatric surgery have significant metabolic and endocrine improvement in obesity, however the results achieved with conventional diet and lifestyle change are poor and not able to reverse this condition. As an alternative to bariatric surgery, we...

Introduction: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia, most cases with parathyroid adenoma as the underlying pathology. However, when blood and urine calcium levels and PTH are higher than normal in PHPT, t’s important to suspect an ectopic PTH secretion or a parathyroid carcinoma. Intrathyroidal parathyroid cysts are extremely rare cause of severe PHPT.Clinical case: A 36-year-old male presented with dizziness ...

Sao Paulo is the most populous city in Brazil and its huge number of vehicles contributes for a higher concentration of air pollutants that may interfere in human fertility. The aim of this study was to evaluate the influence of air pollution of vehicular origin on hormonal and seminal parameters of traffic controllers. Clinical history, physical examination (testicular volume, presence of varicocele, cryptorchidism, malformations), hormonal (estradiol, LH, FSH and total testo...

Development and progression of liver diseases, from non-alcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH), and hepatocellular carcinoma (HCC), seem to be accompanied by a dysregulation of the expression of alternative splicing variants (SVs) and appearance of aberrant SVs. The splicing factor 3B subunit 1 (SF3B1) represents a crucial player for the functional assembly of the spliceosome, the core machinery that controls the splicing process, and its activity can ...