Endocrine Abstracts

Non-alcoholic fatty liver disease (NAFLD) is characterized by the pathological increase of lipid droplets, altered fat metabolism in hepatocytes and increased inflammation. Phosphodiesterase 4 (PDE4) modulates the inflammatory responses and its inhibitor can strongly reduce TNF-α release and inflammation. Additionally, PDE4 knockout mice were shown to be resistant to diet-induced obesity (DIO). The aim of this study was to investigate the role of pharmacological PDE4 inhi...

Obesity is associated with peripheral and central low grade inflammation characterized by the increase in pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF). Phosphodiesterase 4 (PDE4) modulates the inflammatory responses and its inhibitor can strongly reduce TNF release and inflammation. Additionally, PDE4 knockout mice were shown to be resistant to diet-induced obesity (DIO). The aim of this study was to investigate the role of central and peripheral effec...

Short bowel syndrome (SBS) is a complex disease, occurring after extensive resection of the small intestine, leading to malabsorption of nutrients and fluids. Lipids storage significantly affects bone maintenance. Caloric restriction promotes bone and adipose tissue (AT) loss but marrow adipose tissue (MAT) expansion. SBS is a condition strongly associated with malnutrition; patient survival initially depends of caloric replacement through parenteral nutrition (PN). The presen...