Searchable abstracts of presentations at key conferences in endocrinology

ea0022p47 | Adrenal | ECE2010

Genomic DNA alterations in adrenocortical tumors (ACTs): diagnostic and prognostic value

Assie Guillaume , Barreau Olivia , De Reynies Aurelien , Tissier Fredrique , Groussin Lionel , Bertagna Xavier , Bertherat Jerome , Clauser Eric

The outcome of ACTs can be determined by gene expression level at the RNA level. However RNA handling is challenging. In contrast tumor DNA is robust and therefore easier to use.Aim: To characterize the ACTs DNA alterations; to identify markers with diagnostic and prognostic value using tumor DNA.Methods: The mapping of chromosomal gains and losses of 60 ACTs (39 adenomas (ACAs), 21 carcinomas (ACCs)) was performed with CGH arrays ...

ea0032p5 | Adrenal cortex | ECE2013

The gene expression profile of cortisol secretion in adrenocortical adenomas

Roussel Hortense Wilmot , Vezzosi Delphine , Rizk-Rabin Marthe , Barreau Olivia , Ragazzon Bruno , Rene-Corail Fernande , de Reynies Aurelien , Bertherat Jerome , Assie Guillaume

The cortisol secretion level of adrenocortical adenomas range from hormonally silent to overt hypercortisolism. The mechanisms leading to the autonomous hypersecretion of cortisol are unknown. The aim was to identify the gene expression alterations associated with the autonomous and excessive cortisol secretion of adrenocortical adenomas.Methods: The transcriptome of 22 unilateral adrenocortical adenomas (5 non-secreting, 6 subclinical cortisol-producing...

ea0020htc3 | Hot topics: Clinical | ECE2009

ESE Young Investigator Award

Assie Guillaume , de Reynies Aurelien , Rickman David , Tissier Frederique , Groussin Lionel , Rene-Corail Fernande , Dousset Bertrand , Bertagna Xavier , Clauser Eric , Bertherat Jerome

Diagnosing malignancy and assessing the prognosis of adrenocortical tumors is challenging. The aim is to identify molecular predictors of malignancy and of survival.Patients and methods: Of 153 unilateral adrenocortical tumors were studied by microarray (n=92) or RT-qPCR (n=148). A 2-gene predictor of malignancy was built using the disease-free survival as the end-point in a training cohort (n=47), then validated in an independent va...

ea0056oc7.1 | Genomic and clinical aspects of endocrine tumours | ECE2018

Molecular classification of benign adrenocortical tumors: an integrated genomic study

Faillot Simon , Neou Mario , Espiard Stephanie , Vaczlavik Anna , Garinet Simon , Luscap-Rondof Windy , Jouinot Anne , Drougat Ludivine , Groussin Lionel , Perlemoine Karine , Rene-Corail Fernande , Ragazzon Bruno , Rizk-Rabin Marthe , Libe Rossella , Tissier Frederique , De Reynies Aurelien , Bertherat Jerome , Assie Guillaume

Benign adrenal tumors correspond to a spectrum of distinct tumors, including uni- and bilateral diseases with distinct morphological features, and various steroid hormone secretion types and levels. The aim is to study this variability at the molecular level using pan-genomic approaches.Methods: One hundred and forty six benign adrenal tumors, including adrenocortical adenomas (ACA, N=), primary macronodular adrenal hyperplasia (PMAH, N=), and primary pi...