Searchable abstracts of presentations at key conferences in endocrinology

ea0012oc12 | Placenta, bone and genetics | SFE2006

Physiological blockade of gut hormones increases food intake

Kokkinos A , Vincent RP , le Roux CW , Ghatei MA , Bloom SR

BackgroundAppetite is complex, however to address the obesity epidemic, therapeutic agents would have to significantly influence appetite. Currently the most effective treatment for obesity is bariatric surgery because it reduces hunger and increases satiety. The satiety gut hormones such as peptide YY (PYY) and glucagon like peptide 1 (GLP-1) reduce appetite and food intake. Compared to lean and obese subjects, exaggerated postprandial responses of PYY ...

ea0011p592 | Neuroendocrinology and behaviour | ECE2006

Appetite regulating hormones in constitutionally lean and anorexia nervosa subjects

Galusca B , Germain N , le Roux CW , Frere D , Ghatei MA , Bloom SR , Estour B

Energy balance is controlled by the arcuate nucleus through integration of peripheral hormonal signals such as leptin, ghrelin, peptide YY (PYY) and glucagon like peptide 1 (GLP-1). The commonest reason for young women in the developed world to be underweight is restrictive anorexia nervosa (AN). Constitutionally thinness (CT) has been described in young women who satisfies the WHO definition for moderate to severe underweight (BMI 13–16.9 kg/m2). CT women have...