Endocrine Abstracts

Introduction: The 1-mg overnight low-dose dexamethasone suppression test is used as a screening tool when Cushing’s syndrome is suspected. However, the biological confirmation of this syndrome is based upon the measurement of 24-hour urinary free cortisol and low-dose dexamethasone suppression test (Liddle test). The aim of this study was to assess the performance of the 1-mg overnight low-dose dexamethasone suppression test in the diagnosis of Cushing’s syndrome.</p...

Introduction: Patients with permanent hypoparathyroidism receiving conventional treatment have increased risk of subcapsular cataracts, basal ganglia calcifications, urolithiasis and renal insufficiency. The aim of this study was to assess the prevalence and the interfering factors of these complications in patients with permanent hypoparathyroidism.Methods: We conducted a cross-sectional study including 53 patients with permanent hyperparathyroidism. Bi...

Introduction: Patients with permanent hypoparathyroidism suffer from multiple complaints and are exposed to long-term complications that compromise their well-being. The aim of our study was to assess the quality of life in patients with permanent hypoparathyroidism receiving conventional vitaminocalcic therapy.Methods: We conducted a cross-sectional case-control study including 53 patients with permanent hypoparathyroidism and 53 age-sex-body mass index...

Introduction: Spontaneous hypoglycemia in non-diabetic patients is a rare metabolic emergency caused by multiple etiologies. Factitious hypoglycemia, a form of the Munchausen syndrome, is defined as the surreptitious use of insulin or oral hypoglycemic agents to deliberately induce self-harm. It is one of the most challenging diagnoses associated with significant morbidity and mortality. The aim of this study was to assess the prevalence and the associated factors of factitiou...

Introduction: Congenital combined pituitary hormone deficiency (CCPHD) is a rare disorder characterized by an impaired production of two or more hormones of the anterior pituitary gland. It is linked to different genetic mutations and requires an early diagnosis to prevent burdensome developmental consequences. Primary ovarian insufficiency, disparately is the depletion of ovarian function with loss of functional primordial follicles before the age of 40 years due to multiple ...

Introduction: Hypothyroidism is a very common condition, and its treatment is relatively easy with levothyroxine (LT4). However, cases of resistant hypothyroidism were reported despite high doses of levothyroxine. The aim of this study was to evaluate the usefulness of the levothyroxine absorption test to confirm or exclude a disorder of thyroid hormone absorption.Methods: This was a retrospective study including patients who were admitted to our departm...

Introduction: Thyroid hormones have an impact on the function and structure of the cardiac muscle.Aim: Investigate the prevalence and risk factors of structural and functional cardiac complications in patients with hyperthyroidism.Methods: We conducted a cross-sectional study on 30 patients with uncontrolled hyperthyroidism. Clinical, biological and therapeutic data were collected. A trans-thoracic echocardiography (TTE) and lung u...

Introduction: Thyroid hormones represent a biomarker of heart rhythm disorders and pathophysiological origins remain unknown. Some of these disorders like atrial fibrillation (AF) are major issues particularly in asymptomatic patients with in Hyperthyroidism and cause of thromboembolic complications.Aim: Taking into account the uncertainty of prevalence of cardiac rhythm disorders, we aimed to investigate the prevalence of rhythmic cardiac complications ...

Introduction: The occurrence of Cushing’s syndrome in individuals with chronic renal failure is notably rare. It represents a challenging diagnosis in the context of pre-existing chronic kidney disease due to commonly associated alterations in the hypothalamic–pituitary–adrenal axis function. Consequently, the interpretation of standard tests used to detect hypercortisolism can be peculiarly difficult and reveal concrete particularities in comparison to patients...

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with diverse manifestations. Patients with NF1 are particularly prone to developing tumors of the central nervous system (CNS) and endocrine disorders. Herein we report a case of pituitary hyperplasia in a woman with NF1.Observation: A 55-year-old woman was referred to our department for the exploration of recurrent hypoglycemia. Her past medical history included NF1, asthma t...