Searchable abstracts of presentations at key conferences in endocrinology

ea0092ps1-07-01 | Thyroid Cancer Diagnosis 1 | ETA2023

Elevated CRP and leukocytosis at diagnosis, but not elevated ESR, are prognostic markers in anaplastic thyroid cancer

van Houten Pepijn , Jaeger Martin , Netea Mihai , Bonenkamp Han , de Wilt Johannes , Ottevanger Petronella , Walraven Janneke , Netea-Maier Romana

Objectives: Anaplastic thyroid carcinoma (ATC) is one of the malignancies with the highest mortality among all cancers. Immune cells are highly abundant in ATC tumors and increased infiltration with tumor-associated macrophages is associated with decreased survival. We hypothesize that systemic inflammatory markers are also associated with survival in patients with ATC and are more elevated in ATC compared to poorly differentiated thyroid carcinoma (PDTC).<p class="abstext...

ea0099p164 | Thyroid | ECE2024

High local and systemic expression of pentraxin-3 in anaplastic thyroid cancer

Bojoga Andreea , van Houten Pepijn , Jaeger Martin , Rabold Katrin , Ioachim Dumitru , Walgreen Birgitte , van Emst Liesbeth , Badiu Corin , Teodora Netea-Maier Romana

Introduction: Long pentraxin 3 (PTX3), a protein cells produce in response to several inflammatory stimuli, is essential in innate immunity, controlling inflammation, tissue remodeling, and cancer dynamics. PTX3 promotes the migration and invasion of cells in different tumor models. This study aims to (I) immunohistochemically assess the presence and distribution of PTX3 in tissue samples from non-medullary thyroid cancer (NMTC) and (II) (TC) to determine the differences of ci...