Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1226 | Clinical Cases–Pituitary/Adrenal | ECE2015

A case of IgG4 related hypophysitis in a Caucasian female

Hannon Anne Marie , Gupta Saket , Slattery Dave , McGurran Karen , Kinsley Brendan , Javadpour Moshen , Brett Francesca , Agha Amar

IgG4 related hypophysitis is a recently described entity belonging to the IgG4 related diseases. It is characterised by markedly elevated serum IGG4 levels and tissue infiltration by IgG4 positive plasma cells. To date, 34 cases of IgG4 related hypophysitis have been described but only a handful were in women or biopsy proven. We describe a case of a 58 year old woman who presented with transient headache. She also complained of polyuria and nocturia. She had a thyroidectomy f...

ea0031p21 | Bone | SFEBES2013

The utility of neck MRI in the localisation of parathyroid adenomas in primary hyperparathyroidism

Glynn Nigel , Pierce Brian , Hill Arnold DK , McHenry Claire , Smith Diarmuid , Thompson Chris , Keeling Frank , Agha Amar

Neck ultrasound (US) can facilitate minimally invasive parathyroidectomy by providing fine anatomical detail of enlarged parathyroid adenomas in patients with primary hyperparathyroidism (PHPT). The role of neck MRI in US negative/equivocal cases remains unclear. We aimed to evaluate the performance of neck MRI in parathyroid tumour localisation in the setting of negative or equivocal neck US.We performed a retrospective review of a consecutive series of...

ea0029p1376 | Pituitary Clinical | ICEECE2012

Low total cortisol correlates closely with low free cortisol in traumatic brain injury and predicts mortality and long term hypopituitarism

Hannon M. , Crowley R. , Behan L. , O'Sullivan E. , Rogers B. , O'Brien M. , Rawluk D. , O'Dwyer R. , Agha A. , Thompson C.

Published data has demonstrated that low 0900 h plasma total cortisol (PTC) immediately following traumatic brain injury (TBI) predicts mortality. However, potential discrepancies exist between PTC and plasma free cortisol (PFC). We hypothesised that low PTC would correlate closely with PFC and predict mortality and long-term hypopituitarism.One hundred patients (84 men, median age 33, range 18–75) with TBI (mean GCS±S.D.=8.59&#1...

ea0020oc1.2 | Endocrine Tumours | ECE2009

Long-term outcome of laparoscopic versus open adrenalectomy for adrenocortical carcinoma

Fassnacht Martin , Brix David , Fenske Wiebke , Langer Peter , Nies Christoph , Agha Ayman , Beuschlein Felix , Johanssen Sarah , Riedmiller Hubertus , Allolio Bruno

Introduction: Surgery is the established first line treatment in adrenocortical carcinoma (ACC). For benign adrenal tumours, laparoscopic adrenalectomy (LA) has become the treatment of choice. However, the role of LA in ACC remains highly controversial. Data from the German ACC Registry were used to evaluate the technical feasibility of LA in ACC and to compare the long-term outcome after LA with the results of open adrenalectomy (OA).Methods: Out of 521...

ea0015p230 | Pituitary | SFEBES2008

Spontaneous recovery from severe cardiac failure after acute hypotensive infarction of a somatotroph adenoma

Moran Carla , Davenport Colin , Behan Lucy Ann , Draman Mohd Shazli , King Thomas , Sreenan Seamus , Thompson Christopher , Agha Amar

Acromegalic congestive cardiac failure (CCF) is a serious and late complication of untreated acromegaly with associated high morbidity and mortality.1 Spontaneous recovery of end stage acromegalic CCF following autoinfarction of a somatotroph adenoma has not been previously reported.We report the case of a 61-year-old woman who presented with features of severe biventricular CCF and an acromegalic phenotype. Echocardiography revealed poor LV f...

ea0015p240 | Pituitary | SFEBES2008

The short and long-term effect of growth hormone (GH) replacement therapy on quality of life in adults with severe growth hormone deficiency

Behan Lucy Ann , Rogers Bairbre , Connolly Cara , Burrows Samantha , O'Sullivan Eoin P , Crowley Rachel K , Smith Diarmuid , Agha Amar

Adult GH deficiency is associated with poor quality of life (QoL) which has been shown to improve with GH replacement is some but not all, mainly short-term studies. In addition, it remains unclear whether this improvement in QoL is sustainable.We aimed to establish the short and long-term effect of GH replacement on QoL in 167 adult patients with severe GH deficiency in a prospective study. QoL was assessed using the quality of life-assessment of growth...

ea0013p241 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Late development of secondary resistance to cabergoline in a patient with a lactotroph adenoma

Draman Mohd Shazli , Moran Carla , King Tom , Crowley Rachel , O’Sullivan Eoin , Smith Diarmuid , Thompson Christopher , Agha Amar

Primary resistance to Cabergoline occurs in a minority of patients with lactotroph adenomas but the development of late resistance following initial response is an extremely rare phenomenon which has only been reported in very few cases.: We report the case of a 57 year old lady who was presented in 1997 with headaches and visual failure and was found to have a large pituitary mass with compression of the optic chiasm and invasion into the cavernous sinuses bilaterally. Serum ...

ea0086p326 | Metabolism, Obesity and Diabetes | SFEBES2022

Examining the relationship between gestational diabetes, maternal pre-pregnancy body mass index (BMI) and large for gestation age neonates by ethnicity

Chia Eng Pei , Veidi Chiara , Mullins Edward , Terry Jayne , Jones Bryony , Dornhorst Anne , Uduku Chukwuma , Sykes Lynne , Yu Christina , Robinson Stephen , Agha-Jaffar Rochan

Objective: To determine if the impact of pre-pregnancy body mass index (BMI), fasting glucose levels and post load glucose levels on large for gestational age neonates varies with ethnicity.Data sources: Electronic health records of all eligible pregnant women in an inner city service. Study designRetrospective analysis of pregnant women at risk of developing gestational diabetes mellitus (2016-2019) of. Population or sampleEligible pregnant women. Synth...

ea0037gp.04.02 | Steroids | ECE2015

The modulation of corticosteroid metabolism by hydrocortisone therapy in patients with hypopituitarism increases tissue glucocorticoid exposure

Sherlock Mark , Behan Lucy Ann , Hannon Mark , Alonso Aurora Aragon , Thompson Christopher , Murray Robert , Crabtree Nicola , Hughes Beverly , Arlt Wiebke , Agha Amar , Toogood Andrew , Stewart Paul M

Context: Patients with hypopituitarism have increased morbidity and mortality. There is ongoing debate around the optimum glucocorticoid replacement therapy.Objective: To assess the effect of glucocorticoid replacement in hypopituitarism on corticosteroid metabolism and its impact on body composition.Design and patients: We assessed the urinary corticosteroid metabolite profile (using gas chromatography/mass spectrometry) and body ...

ea0037ep744 | Pituitary: clinical | ECE2015

Symptoms of gonadal dysfunction are more predictive of hypopituitarism than non-specific symptoms in screening for pituitary dysfunction following moderate or severe traumatic brain injury

Hernandez Martin Cuesta , Hannon Mark J , Crowley Rachel K , Behan Lucy Ann , Tormey William , Rawluk Daniel , Delargy Mark , Agha Amar , Thompson Christopher J

Context: The economic and logistic burden of screening for hypopituitarism following moderate/severe traumatic brain injury (TBI) is considerable. Published guidelines suggest prioritisation for screening of patients with symptoms of pituitary dysfunction.Objective: To evaluate the implementation of targeted symptom-based screening for hypopituitarism after moderate/severe TBI, compared with routine consecutive screening.Design: Gr...