Searchable abstracts of presentations at key conferences in endocrinology

ea0081p590 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Type 1 diabetes on continuous subcutaneous insulin infusion: impact of glycaemic control on quality of life

Carreira Ana , Ferreira Mafalda , Vieira Ines , Lavrador Mariana , Barros Luisa , Baptista Carla , Moreno Carolina , Melo Miguel , Paiva Isabel

Background: In type 1 diabetes (T1D), quality of life (QoL) and the effectiveness of treatment influence each other. QoL has been associated with glycaemic control assessed by HbA1c in T1D on continuous subcutaneous insulin infusion (CSII), but data on the relationship between Continuous Glucose Monitoring (CGM) metrics and QoL are scarce.Objectives: To assess QoL and the association between CGM metrics and QoL in T1D on CSII.Metho...

ea0081p450 | Reproductive and Developmental Endocrinology | ECE2022

Influence of polycystic ovary syndrome on in vitro fertilization and relationship with the Asn680Ser polymorphism in FSHR gene

Vieira Ines , Filipa Ferreira Ana , Carvalho Alexandra , Dias Conceicao , Fernandes Silvana , Rodrigues Dircea , Cortesao Paulo , Almeida Santos Teresa , Paiva Isabel

Introduction: Polycystic ovary syndrome (PCOS) is a frequent cause of infertility. Its influence on the results of in vitro fertilization (IVF) is controversial, and generally not isolated from the effect of obesity. A relationship between the FSH receptor (FSHR) polymorphism Asn680Ser and the risk and phenotype of PCOS has been studied with conflicting results.Objectives: To analyze the influence of obesity and PCOS on the gonadal axis...

ea0063p242 | Pituitary and Neuroendocrinology 1 | ECE2019

Pituitary tumors diagnosed in octogenarians – clinical implications

Cunha Nelson , Gomes Leonor , Paiva Isabel , Fadiga Lucia , Catarino Diana , Silva Diana , Guiomar Joana , Vieira Ines , Lavrador Mariana , Bastos Margarida

Introduction: The aging population brought new challenges in several diseases. Pituitary tumors are usually not related with elderly, although the rise in life expectancy has allowed its diagnosis in unusual age groups.Aim: To describe the pituitary tumors diagnosed in patients with age ≥ 80 yearsMethods: Retrospective observational study which included 23 patients with pituitary tumors with age ≥ 80 years observed in c...

ea0035p296 | Clinical case reports Thyroid/Others | ECE2014

Type 2 polyglandular autoimmune syndrome and Turner syndrome

Moreno Carolina , Rodrigues Dircea , Vieira Alexandra , Ruas Luisa , Saraiva Joana , Guelho Daniela , Cardoso Luis , Vicente Nuno , Carrilho Francisco

Introduction: Individuals with Turner syndrome (TS) are prone to develop autoimmune conditions. The most frequently found are Hashimoto’s thyroiditis, type 1 diabetes, coeliac disease, and inflammatory bowel disease. In patients with TS, Addison’s disease isolated or combined with other autoimmune disease as type 2 polyglandular autoimmune syndrome, is a rare finding.Case report: We report a case of a 41-year-old female patient, with severe ast...

ea0070aep644 | Pituitary and Neuroendocrinology | ECE2020

A case of developmental delay by 18q23 deletion syndrome

Chaves Catarina , Martinho Mariana , Brandão Carla , Rodrigues Catarina , Cunha Filipe , Garrido Susana , Vieira Margarida , Almeida Margarida

Introduction: Monosomy 18q represents a partial deletion of the long arm of chromosome 18, with an estimated prevalence of 1:100 000. This syndrome is characterized by a highly variable phenotype. The symptoms and their severity depend on which part of the chromosome is missing. Most common manifestations are hypotonia, developmental delay, short stature, growth hormone deficiency, hearing loss and external ear anomalies, intellectual disability, palatal defects, dysmorphic fa...

ea0070aep664 | Pituitary and Neuroendocrinology | ECE2020

The role of repeated prolactin samples in patients with hyperprolactinaemia

Rodrigues Catarina , Cunha Filipe , Chaves Catarina , Silva Vieira Margarida , Silva André , Garrido Susana , Martinho Mariana , Almeida Margarida

Introduction: Current guidelines recommend a single prolactin sampling for the diagnosis of hyperprolactinaemia. Nonetheless, in some patients, prolactin levels may normalize in a subsequent sampling or if prolactin is collected through a venous catheter some time after puncture. We aimed to assess the percentage of patients in which prolactin remained elevated in repeated sampling and to determine the best prolactin cutoff associated with persistent hyperprolactinaemia.<p...

ea0029p407 | Clinical case reports - Thyroid/Others | ICEECE2012

Considering familial benign hypocalciuric hypercalcemia on differential diagnosis of primary hyperparathyroidism

Gouveia S. , Paiva S. , Gomes L. , Ribeiro C. , Vieira A. , Alves M. , Saraiva J. , Moreno C. , Carvalheiro M.

Introduction: Primary hyperparathyroidism is the most common cause for hypercalcemia. Familial benign hypocalciuric hypercalcemia (FBHH) is an unusual autosomal dominant disease. The mutation in the calcium sensing receptor (CaSR) determines a shift to the right in the calcemia set-point that inhibits PTH secretion. Generally asymptomatic, these patients present with mild hypercalcemia and hypophosphatemia, normal or slightly increased PTH levels and hypocalciuria. Daily calci...

ea0029p878 | Endocrine tumours and neoplasia | ICEECE2012

Metastatic malignant insulinoma

Moreno C. , Rodrigues A. , Gomes L. , Ruas L. , Barros L. , Paiva S. , Vieira A. , Alves M. , Gouveia S. , Saraiva J. , Carvalheiro M.

Introduction: Insulinomas are the most common form of functioning pancreatic neuroendocrine tumors (NET) with an estimated incidence of 1–3/million per year. Less than 10% are malignant and rarely with distant metastases, carrying a poor prognosis.Case report: We report a case of a 73-years-old woman attended at our ER for recurrent syncope, with irrelevant medical history. Several radiology exams were preformed, revealing numerous liver metastases ...

ea0026p229 | Pituitary | ECE2011

Clinical and subclinical apoplexy in nonfunctioning pituitary tumors: clinical features, management and outcome

Gomes Leonor , Paiva Isabel , Ribeiro Cristina , Santos Jacinta , Vieira Alexandra , Alves Marcia , Gouveia Sofia , Saraiva Joana , Rebelo Olinda , Carvalheiro Manuela

Background: Pituitary apoplexy occurs when a tumor undergoes acute hemorrhage, infarct, or both. This often leads to acute severe symptoms (clinical) but can also occur without them and diagnosed on CT/MRI, surgery, pathology (subclinical). To investigate clinical and subclinical apoplexy in nonfunctioning tumors (n=221) from our database.Design: Retrospective review of clinical presentation, tumor characteristics and outcome of 24 patients, 11 fe...

ea0022p185 | Clinical case reports and clinical practice | ECE2010

Primary biliary cirrhosis and Graves’ disease – combination rarely found

Vieira Alexandra , Paiva Sandra , Ribeiro Cristina , Santos Jacinta , Martinho Mariana , Alves Marcia , Gouveia Sofia , Carrilho Francisco , Carvalheiro Manuela

Introduction: The association of autoimmune diseases in the same individual is common. It is well documented that Graves’ disease (GD) is associated to various autoimmune diseases, including: pernicious anemia, vitiligo, type 1 diabetes, Addison’s disease, systemic sclerosis, myasthenia gravis, Sjogren’s syndrome, rheumatoid arthritis and systemic lupus erythematosus. In addition, primary biliary cirrhosis (PBC) may be associated with rheumatoid arthritis, Sjogr...