Searchable abstracts of presentations at key conferences in endocrinology

ea0077p104 | Reproductive Endocrinology | SFEBES2021

An exploration of the association between CAG repeat status and mortality in men

Heald Adrian , Cook Michael , Javed Ahmed , Fachim Helene , O’Neill Terence , Wu Fred

Introduction: The androgen receptor (AR) mediates the peripheral effects of testosterone. The main mechanism of action for the AR is direct regulation of gene transcription. Available evidence suggests that the number of CAG repeats in exon-1 of the AR gene is negatively correlated with transcriptional activity of the AR and that CAG repeat number links to mortality rate in T2DM men. The aim of this analysis was to determine the association between CAG repeat number and all ca...

ea0084op-01-03 | Oral Session 1: Topic Highlights | ETA2022

The relationship between thyroid function and lipid metabolomics and response to combination thyroid hormone replacement

Taylor Peter , Hanna Stephanie , Okosieme Onyebuchi , Stedman Michael , Heald Adrian , Premawardhana Lakdasa , Dayan Colin

Objective: Thyroid hormones are essential for maintaining metabolic balance and particularly influence lipid synthesis and degradation. Metabolomics and in-depth lipid profiling may enable us to assess for differential effects of thyroid hormones and provide insight into tissue thyroid status, that cannot be captured by levels of serum free thyroid hormones alone.Methods: 4,347 children from the Avon Longitudinal Study of Parents and Children who had thy...

ea0086ec1.3 | Clinical Endocrinology Trust Best Abstract Clinical | SFEBES2022

Individuals on levothyroxine have higher HADS anxiety and depression scores than the general population and this is exacerbated by the Thr92Ala substitution in DIO2

Taylor Peter , Haug Eirin , Heald Adrian , Premawardhana Lakdasa , Okosieme Onyebuchi , Stedman Michael , Asvold Bjorn , Dayan Colin

Introduction: Around 15% of people diagnosed with primary hypothyroidism remain significantly symptomatic despite TSH normalisation with levothyroxine (LT4). The Thr92Ala substitution (rs225014) in a key deiodinase that activates T4 to T3, DIO2 may influence tissue levels of T3 but previous studies have been inconsistent regarding symptoms on LT4 and the presence of this polymorphism.Methods: We assessed HADS anxiety and depression scores in the HUNT2 st...

ea0086p75 | Metabolism, Obesity and Diabetes | SFEBES2022

Health Inequality and its link to HbA1c Test Recovery in a Developed Health Economy: In a ‘Nearly Post COVID-19’ World

Heald Adrian , Holland David , Duff Christopher J , Scargill Jonathan , Hanna Fahmy , Fryer Anthony

Background: We previously showed that in first 6 months of the UK Covid-19(C19) pandemic >6.6million HbA1c tests were missed, including 1.4million in people with diabetes(DM). Furthermore, C19 more significantly impacts people with DM / socioeconomically disadvantaged individuals.Aim: To examine variability in recovery rate of HbA1c testing, and links to demographics, including deprivation status.Methods: We examined HbA1c test...

ea0086p126 | Reproductive Endocrinology | SFEBES2022

Experience of Prescribing Testosterone Gel to Menopausal Women at a Single UK Centre: The Biochemistry and The Patent Experience

Heald Adrian , Naseem Asma , Keatley Claire , Duran Beatriz , Cortes Moreno Gabriela , Panay Nick

Introduction: It has been suggested that sexual dysfunction affects as many as 43% of women in the population. In relation to this, symptoms of hypoactive sexual desire disorder (HSDD) can be alleviated with testosterone replacement.Aim: To determine what is the pre- and 24-hour post dose circulating level of testosterone in women applying Testogel 16.2 mg/g.Methods: In a group of 10 menopausal women applying Testogel 16.2 mg/g at ...

ea0086p135 | Thyroid | SFEBES2022

Thyroid function testing in people treated with Lithium: We are doing more thyroid tests than is necessary

Duce Helen , Duff Christopher J , Syed Zaidi , Parfitt Ceri , Fryer Anthony , Heald Adrian

Introduction: Lithium is a common pharmacological intervention for the treatment of bipolar affective disorder and is advocated by clinical practice guidelines (NICE 2021). Blood test monitoring is essential for management of lithium treatment and UK NICE guidance recommends 6-monthly serum testing of thyroid function. We here examine conformity to guidance and the consequences of monitoring outside these intervals.Methods: We extracted serum lithium/thy...

ea0065p191 | Metabolism and Obesity | SFEBES2019

Male testosterone levels and laboratory practice: a need for a standardised approach to measurement and reporting

Livingston Mark , Downie Paul , Hackett Geoffrey , Marrington Rachel , Heald Adrian , Ramachandran Sudarshan

Background: Diagnosis and treatment guidelines of men with adult-onset testosterone deficiency (TD) were published by the British Society for Sexual Medicine (2017). Laboratory practice has a major role in supporting these with accurate and precise total testosterone (TT) methods and standardised pre- and post-analytical protocols.Objective: Our study investigated whether laboratory practice supported management guidelines of adult-onset TD.<p class=...

ea0065p279 | Neuroendocrinology | SFEBES2019

CACNA1C genotype does influence CACNA1C methylation and the association with cortisol release/potential mental health resilience

Pennington Kyla , Klaus Kristel , Fachim Helene , Trischel Ksenia , Dalton Caroline , Reynolds Gavin , Heald Adrian

Introduction: CACNA1C gene encodes the L-type voltage dependent calcium channels and its variants are associated with susceptibility to psychiatric disorders. We recently provided evidence of a genotype-by-environment interaction of the CACNA1C rs1006737 polymorphism, suggesting that the cortisol awakening response (CAR), an indicator of HPA-axis function, might be increased in non-risk allele carriers (GG) who have experienced childhood trauma (CT). In these...

ea0065p374 | Reproductive Endocrinology and Biology | SFEBES2019

Diagnostic evaluation of polycystic ovarian syndrome: how the biochemistry stacks up against subsequent ultrasound scan evaluation

Karia Amar , Duff Christopher , Heald Adrian , Britton Ingrid , Fryer Anthony , Wu Pensee

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age. PCOS is associated with future type 2 diabetes/cardiovascular disease. Accurate diagnosis is important for early preventative interventions. However, it can take >2 years and contact with 3 or more health professionals before PCOS is diagnosed. We aimed to determine patterns of biochemical investigations performed for PCOS following initial consultation and assess their ...

ea0031p137 | Cytokines and growth factors | SFEBES2013

Genes for IGF2 and related IGF binding proteins are associated with longitudinal trends in BMI

Narayanan Ram Prakash , Fu Bo , Payton Antony , Donn Rachelle , Heald Adrian , Ollier William ER , Gibson Martin

High IGF2 has been associated with longitudinal weight loss. We wished to study associations of genes coding for IGF2 and for binding proteins that have preferential IGF2 affinity (IGFBP2, IGFBP5 and IGFBP6) in 991 Caucasian subjects from Salford with type 2 diabetes.Fifteen IGF2, four IGFBP2, eight IGFBP5 and one IGFBP6 SNPs were successfully genotyped. Longitudinal BMI data for the years 2002 to 2009 was obtained fro...