Searchable abstracts of presentations at key conferences in endocrinology

ea0104p11 | Adrenal & Cardiovascular | SFEIES24

Salivary cortisol vs serum cortisol in the overnight dexamethasone suppression test: results of a service evaluation at one centre

Heald Adrian , Majeed Waseem , Taylor Peter , Michaelidou Maria , Syed Akheel , Keevil Brian

Introduction: Saliva hormone measurements are increasingly being applied in every day clinical practice. In relation to salivary cortisol/cortisone measurement there is a particular advantage, with minimal chance of cross reaction with prescribed glucocorticoids. We here evaluated the utility of these measurements in patients undergoing an overnight (1 mg) dexamethasone suppression test (ONDST).Methods: A service evaluation of salivary cortisol/cortisone...

ea0104p45 | Bone & Calcium | SFEIES24

Influence of ethnicity and deprivation on occurrence of paget’s disease in greater manchester, uk (population 2.85 million)

Heald Adrian , Lu Wenqi , Williams Richard , Mccay Kevin , Maharani Asri , Cook Michael , O'Neill Terence

Introduction: There is variation in Paget’s disease occurrence in different regions/populations. We looked at Paget’s occurrence (GP-coded diagnosis) in a large UK urban conurbation and explored the influence of age/gender/ethnicity on occurrence. We also looked at the impact of Paget’s disease on the severity of COVID-19 infection.Methods: We undertook an anonymised search using an integrated primary/secondary care-based database in Great...

ea0077p64 | Metabolism, Obesity and Diabetes | SFEBES2021

The Variability In Glycosylated Haemoglobin (HbA1c) Testing Interval In People With Diabetes Is Linked To Long-Term Diabetes Control, Independent of HbA1c Test Interval

Heald Adrian , Holland David , Stedman Michael , Duff Chirstopher J , Green Lewis , Scargill Jonathan , Hanna Fahmy WF , Wu Pensee , Fryer Anthony A

Introduction: Worldwide guidance advocates regular HbA1c testing for people with diabetes mellitus, usually 2-4/yr. We previously showed that HbA1c testing frequency is linked to outcome in terms of HbA1c control. Here we examine the effect of variability (standard deviation = SD) in test interval on change in HbA1c over 7 yrs (Jun 2012-Jul 2019) using laboratory data.Methods: We focused on people with HbA1c within the first 2 years who also had a HbA1c ...

ea0050oc3.5 | Obesity, Diabetes Thyroid | SFEBES2017

Increased global long interspersed nucleotide element 1 DNA methylation in type 2 diabetes mellitus individuals relates to lower blood pressure and BMI

Malipatil Nagaraj , Siddals Kirk , Moreno Gabriela , Narayanan Ram , Donn Rachelle , Lunt Mark , Heald Adrian H , Gibson J Martin

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...

ea0050oc3.5 | Obesity, Diabetes Thyroid | SFEBES2017

Increased global long interspersed nucleotide element 1 DNA methylation in type 2 diabetes mellitus individuals relates to lower blood pressure and BMI

Malipatil Nagaraj , Siddals Kirk , Moreno Gabriela , Narayanan Ram , Donn Rachelle , Lunt Mark , Heald Adrian H , Gibson J Martin

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...

ea0065p28 | Adrenal and Cardiovascular | SFEBES2019

Recalibration of thinking about adrenocortical function assessment: How the random cortisol relates to the short Synacthen test ‘Verdict’

Michaelidou Maria , Yadegarfar Ghasem , Robinson Adam , Naseem Asma , Khan Inamullah , Kochhar Rupinder , Scargill Jonathan , Trainer Peter , Heald Adrian

Background: The short synacthen test (SST) is the most commonly performed investigation to assess for suspected adrenocortical dysfunction. We investigated how random cortisol levels may relate to pass/fail on the STT.Methods: We analysed the relation between random cortisol measurements taken between 04.40 and 20.52 in the day and results of SST baseline and 30/60 min cortisol performed over a 12 month period (338 SSTs) at Salford Royal Hospital. Serum ...

ea0065p176 | Metabolism and Obesity | SFEBES2019

Brain derived neurotrophic factor (BDNF) methylation in patients with impaired glucose regulation: implications progression to type 2 diabetes mellitus (T2DM)

Fachim Helene , Siddals Kirk , Malipatil Nagaraj , Cortes Gabriela , Donn Rachelle , Dalton Caroline , Reynolds Gavin , Gibson Martin , Heald Adrian

Introduction: There is growing evidence of external factors modulating epigenetic modifications and their contribution to the development of obesity and T2DM. One of the epigenetic signatures is DNA methylation. We investigated whether a lifestyle intervention could influence DNA methylation of Brain derived neurotrophic factor (BDNF) in individuals with IGR, as BDNF is thought to play an important role in glucose metabolism.Methods: IGR participants (<e...

ea0065p189 | Metabolism and Obesity | SFEBES2019

The FreeStyle libre flash glucose monitoring system: how it has improved glycaemic control for people with type 1 diabetes (T1DM) in Eastern Cheshire, UK

Dwived Shivangi , Heald Adrian , Naseem Asma , Kochhar Rupinder , Khan Inamullah , Leivesley Kate , Metters Ann , Horne Linda , Steele Tom

Introduction: Many people with type 1 diabetes continue to experience suboptimal glycaemic control. We now also know that often HbA1c levels are an inaccurate reflection of glycaemic patterns and variability. We describe here how the systematic use of the FreeStyle Libre flash monitor helped improve the glycaemic control of many people with type 1 diabetes.Methods: We report the outcomes of 92 consecutive adults (18 years of age or more) with type 1 diab...

ea0065p412 | Thyroid | SFEBES2019

Health utility of people with treatment-resistant hypothyroidism as measured with the EQ-5D-5L quality of life questionnaire

Hughes Dyfrig , Townson Julia , Owen-Jones Eleri , Playle Rebecca , Khan Inamullah , Kochhar Rupinder , Naseem Asma , Heald Adrian

Background: Primary hypothyroidism affects about 3% of the general population (5.1% women and 0.9% men). The majority of people are treated adequately with levothyroxine. However about 5–10% of hypothyroid patients (representing between 75 000 and 150 000 adults in the UK) continue to experience profound and sometimes disabling symptoms, such as fatigue/depression/impaired cognition, in spite of being adequately replaced biochemically. Before any trial of alternatives to ...

ea0031p139 | Cytokines and growth factors | SFEBES2013

IGF binding protein-2 is associated with all-cause and cardiovascular mortality in type 2 diabetes

Narayanan Ram Prakash , Oliver Robert L , Siddals Kirk W , Heald Adrian H , Ollier William E R , Gibson J Martin

Low IGFBP2 is associated with the metabolic syndrome, but high IGFBP2 is longitudinally associated with worsening renal function. IGFBP2 binds IGF2 (and IGF1) and modified IGF bioavailablilty. The aim of our study was to identify whether baseline IGFBP2 concentrations were associated with all-cause and cardiovascular mortality in type 2 diabetes.554 subjects (59.3% male, mean age 63.7 (S.D. 10.7)) with type 2 diabetes from the Salford Diab...