Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp237 | Thyroid Cancer (1) | ECE2016

The origin of patients with inherited medullary thyroid cancer, who are carriers of the rare exon 8 mutation (G533C) of the RET gene in Greece

Saltiki Katerina , Anagnostou Elli , Angelopoulou Anastasia , Kouki Sofia , Apostolakis Michail , Sarika Lida , Papathoma Alexandra , Alevizaki Maria

Introduction: Mutations in the ret gene are responsible for the transmission of inherited medullary thyroid cancer (MTC). In recent years a high prevalence of the ‘rare’ exon 8 mutation (G533C) has been found in patients with inherited MTC in Greece. The aim of this study was to record with more detail the place of origin of these families in the country.Design: We analysed the details of 44 patients belonging to 22 families who were c...

ea0037gp.23.08 | Thyroid – diagnosis | ECE2015

Clinical characteristics in sporadic and familial medullary thyroid carcinomas: worse outcome in sporadic cases even when disease stage at diagnosis is similar

Saltiki Katerina , Spanou Loukia , Kouki Sofia , Rentziou Gianna , Vasileiou Vasiliki , Anastasiou Eleni , Alevizaki Maria

Objectives: Medullary thyroid carcinoma (MTC) has varying clinical course with familial cases (fMTC) diagnosed earlier than sporadic ones (sMTC). We examined the presentation of these entities in our centre.Methods: 223 MTC patients (familial: 42.6%, males: 36.8%) were followed for 0.9–30 years (mean 6.23±5.9, median 4.0 years). 44 (19.7%) fMTC patients were operated after genetic screening.Results: Median age at diagnosi...

ea0037gp.27.03 | Thyroid – hyperthyroidism and treatment | ECE2015

Clinical and biochemical factors affecting prognosis of disease persistence in micro papillary thyroid carcinomas

Saltiki Katerina , Apostolakis Michael , Kouki Sophia , Spanou Loukia , Athanasiadou Anastasia , Zapanti Evangelia , Alevizaki Maria

Introduction: In recent years, micro papillary thyroid carcinomas (mPTCs; ≤1.0 cm) are increasingly diagnosed. Although clinical course is usually favourable, disease persistence may occur and multiple treatments needed. We examined factors that could be predictors of clinical behaviour and disease persistence.Patients and methods: 478 mPTC patients (78.9% females) followed-up for 0.6–10 years were classified according to tumour size in group ...

ea0035p1080 | Thyroid (non-cancer) | ECE2014

Associations of thyroid function and autoantibodies with parameters of oxidative stress in women with Hashimoto's thyroiditis

Giannakou Maria , Saltiki Katerina , Loukari Eleni , Mantzou Emily , Philippou George , Terzidis Konstantinos , Stavrianos Charalampos , Alevizaki Maria

Objectives: Patients with thyroid dysfunction due to AITD have been found to have increased oxidative stress. Possible associations of oxidative stress with thyroid hormone (TH) and thyroid autoantibodies (ThAb) levels in euthyroid patients with autoimmune thyroiditis have not been adequately studied. We examined possible associations of oxidative stress markers with TH levels and with the presence of ThAb in euthyroid women with Hashimoto’s thyroiditis (with or without T...

ea0035p1102 | Thyroid Cancer | ECE2014

Familial medullary thyroid carcinomas: RET mutation in exon 8 is associated with better prognosis but increased risk for other malignancies

Saltiki Katerina , Rentziou Gianna , Angelopoulou Anastasia , Apostolakis Michael , Papathoma Alexandra , Alevizaki Maria

Objectives: In familial MTC there is genotype-phenotype correlation. The phenotype and clinical outcome in exon8 (G533C) carriers has not been well established.Methods: 95 patients operated for familial MTC (27.2% males) were followed for 0.9–30 years (mean 8.0, median 5.5 years). 45.3% (n=43) were exon8 carriers (exon8MTC) and the remaning were non-exon8MTCs (n=52, exons 10, 11, 13, 14, and 16). Pre-, postoperative calcitonin, ext...

ea0032p1085 | Thyroid cancer | ECE2013

Pre-existing autoimmune thyroid disease may influence the course of the disease in differentiated thyroid carcinoma patients

Athanasiadou Anastasia , Saltiki Katerina , Rentziou Gianna , Papageorgiou George , Anastasiou Eleni , Alevizaki Maria

Introduction: Differentiated thyroid carcinoma (DTC) has generally a good prognosis and is associated with prolonged survival. A minority of patients may have persistent disease and rarely aggravation during f/u. We investigated factors which may influence the persistence of disease in patients who had undergone ablation with I131.Patients and methods: 903 DTC patients were referred in our center from 1968 to 2012. Five hundred and forty-one (...

ea0032p1121 | Thyroid cancer | ECE2013

Clinical and biochemical criteria for the prognosis of small medullary thyroid carcinomas

Saltiki Katerina , Rentziou Gianna , Vasileiou Vasiliki , Athanasiadou Anastasia , Anastasiou Eleni , Alevizaki Maria

Introduction: Recently, small medullary thyroid carcinomas (sMTCs) (≤1.5 cm) are frequently diagnosed, occasionally as incidental findings in surgical and autopsy specimens. Their clinical course varies. We examined whether tumor size is a predictor of clinical behavior.Patients and methods: One hundred and one sMTC patients (36.6% males, 47.1% familial) followed-up for 0.9–35 years. Patients were classified according to tumor size (cm) in gro...

ea0026p356 | Steroid metabolism | ECE2011

Hormonal parameters and sex hormone receptor gene polymorphisms in males with autoimmune diseases

Doukas Charalampos , Saltiki Katerina , Terzidis Kostas , Mantzou Aimily , Sarika Lida , Cimponeriu Andriana , Sfikakis Petros , Alevizaki Maria

Introduction: Autoimmune disease (AD) is more common in women than in men. Sex hormones may play a role. Sex hormone receptors (SHR) are expressed in cells of the autoimmune system. We investigated the possible role of hormonal parameters and of common gene polymorphisms of the estrogen receptor alpha (ESR1), beta (ESR2) and androgen receptor (AR) in the presence of AD in men.Methods: In total 227 men were studied; 125 had at least o...

ea0022p127 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Subjects homozygous for the BCL1 polymorphism of glucocorticoid receptor gene may have an increased risk for impaired endothelial function

Stamatelopoulos Kimon , Saltiki Katerina , Mantzou Emily , Voidonikola Paraskevi , Papamichael Christos , Alevizaki Maria

Objectives: Glucocorticoids may affect cardiovascular risk. Polymorphisms in the glucocorticoid receptor (GlucR) gene have been associated with increased risk for cardiovascular disease. We investigated whether the common Bcl1 polymorphism of the GlucR gene (associated with increased sensitivity to glucocorticoids) may be associated with early markers of atherosclerosis.Methods: Two hundred and fourteen middle aged apparently healthy subjects (age &#8230...

ea0022p315 | Diabetes | ECE2010

Vitamin D deficiency and isolated fasting hyperglycemia in pregnancy

Vasileiou Vasiliki , Athanasiadou Anastasia , Giakoumi Athanasia , Papageorgiou George , Zapanti Evangelia , Alevizaki Maria , Anastasiou Eleni

Introduction: The relation between vitamin D deficiency and gestational diabetes mellitus (GDM) has been rarely addressed in the literature with conflicting results. The aim is to determine the association between maternal serum 25(OH)D and glucose metabolism in Caucasian pregnant women.Patients and methods: In a prospective study 157 pregnant women aged 31.2±5.8 years underwent a 100 g OGTT in the third trimester of pregnancy, during which serum 25...