Searchable abstracts of presentations at key conferences in endocrinology

ea0022p478 | Female reproduction | ECE2010

The polymorphic Alu1 variant of ERβ may modulate the feedback regulation of LH secretion

Saltiki Katerina , Mantzou Emily , Anastasiou Eleni , Pappa Theodora , Huhtaniemi Ilpo , Alevizaki Maria

A common polymorphism of the ERβ gene (AluI) located in 3′-UTR of exon 8 has been shown to be associated with clinical features of altered estrogen action in tissues where this gene is expressed. It has recently been shown that GnRH neurons express ERβ, indicating that this receptor may participate in the feedback regulation of gonadotrophin secretion. We therefore studied the association of gonadotrophin levels and the AluI polymorp...

ea0022p841 | Thyroid | ECE2010

Effects of rhTSH administration on 24 h arterial pressure in subjects undergoing evaluation for differentiated thyroid cancer

Rentziou Gianna , Manios Eustathios , Mantzou Emily , Saltiki Katerina , Michas Fotios , Zakopoulos Nikos , Alevizaki Maria

Background: TSH levels within the normal range have been associated with increased blood pressure (BP). TSH itself might be involved, especially as extrathyroidal actions of TSH exist.We investigated whether elevated TSH levels after acute rhTSH administration may result in alterations in BP in euthyroid individuals.Methods: Twenty-six euthyroid female subjects thyroidectomised and on T4 suppressive dose, were evaluated ...

ea0020p304 | Clinical case reports and clinical reports | ECE2009

Double primary ovarian malignancies in a patient with bipolar disease complicating Swyer syndrome

Zapanti Evangelia , Giakioumi Athanasia , Terzidis Konstantinos , Thomakos Nikolaos , Rodolakis Alexandros , Grigori P , Alevizaki Maria

Background: Swyer syndrome is a type of pure gonadal dysgenesis 46 XY caryotype in phenotypically female patients. A rare case of Swyer syndrome complicated by dysgerminoma and Retiform Sertoli-Leydig cell’s tumor is reported.Case presentation: A 20-year-old phenotypically female patient presented to our department with primary amenorrhea. She was 1.68 m and weighed 82 kg (BMI 28). She presented with minimal breast development, sparse axillary and p...

ea0020p355 | Diabetes and Cardiovascular | ECE2009

Endogenous estrogen levels are associated with endothelial function in males independently of lipid levels

Saltiki Katerina , Stamatelopoulos Kimon , Voidonikola Paraskevi , Mantzou Emily , Papamichael Christos , Alevizaki Maria

Introduction-aim: It has been suggested that estrogen may play an important role in the regulation of endothelium-dependent vasodilatation in both sexes. Especially in men, estradiol administration has been shown to improve endothelial function; however such reports are conflicting. The aim of our study was to examine the relation of endogenous sex hormone levels with markers of early atherosclerosis in a cohort of apparently healthy individuals.Methods:...

ea0020p455 | Obesity and Metabolism | ECE2009

Thyroid function tests, measures of adiposity and metabolic syndrome in apparently healthy euthyroid individuals

Saltiki Katerina , Stamatelopoulos Kimon , Voidonikola Paraskevi , Mantzou Emily , Papamichael Christos , Alevizaki Maria

Objective: Thyroid function tests (TFTs) have been associated with obesity; however associations with the type of adiposity have not been examined. Ultrasound (U/S) was used to assess regional adiposity in euthyroid individuals. Associations of thyroid function with obesity parameters and presence of the metabolic syndrome (MS) were investigated.Methods: Of 302 apparently healthy slightly overweight individuals (age 42.9±8.8, BMI 19.0–43.3, med...

ea0020p669 | Steroid Receptors | ECE2009

Androgen receptor gene CAG(n) repeat polymorphism and coronary artery disease (CAD) in women

Alevizaki Maria , Saltiki Katerina , Cimponeriu Adriana , Garofalaki Maria , Mantzou Emily , Stamatelopoulos Kimon

Objective: Androgen may be detrimental for vascular health in women. Sensitivity to androgen is influenced by the CAG repeat length of the androgen receptor (AR) gene. We investigated possible associations between the CAG repeat polymorphism with the severity of CAD in women undergoing coronary angiography.Methods: We examined 131 postmenopausal women (45–88 years). CAD severity was assessed by the number of coronary vessels with >50% stenosis. ...

ea0016p761 | Thyroid | ECE2008

Thyroid volume, selenium levels and nutritional habits in Southwestern Albania

Doupis John , Saltiki Katerina , Mantzou Emily , Mastrokostopoulos Antonios , Stavrianos Charalambos , Alevizaki Maria

Introduction: Aim: it is known that environmental factors are involved in the development of goiter. A high number of goitrous patients was identified among patients attending the general medicine outpatients’ in a mountainous region in Albania. We examined possible associations of thyroid enlargement with nutritional factors.Methods: One hundred and twelve consecutive patients (mean age 52.8±12.1, 104 female) attending the outpatients of the G...

ea0014oc6.6 | Cardiovascular endocrinology | ECE2007

The importance of the TAAAA(n) alleles at the SHBG gene promoter for the severity of cardiovascular disease in women

Saltiki Katerina , Xita Nectaria , Cimponeriu Adriana , Kanakakis Ioannis , Mantzou Emily , Doukas Charalambos , Georgiou Ioannis , Alevizaki Maria

Objective: Androgen may be detrimental in the development of coronary artery disease (CAD) in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and the severity of CAD in women.Methods: One hundred and twenty women (37–82 yrs), undergoing coronary angiography. CAD severity, history of angina, myocardial infa...

ea0014p234 | (1) | ECE2007

Association of sex hormone-binding globulin (shbg) levels with measures of adiposity and metabolic profile in apparently healthy individuals

Saltiki Katerina , Voidonikola Paraskevi , Stamatelopoulos Kimon , Mantzou Emily , Chryssohoou Eleftheria , Papamichael Christos , Alevizaki Maria

Objective: The association of SHBG levels with obesity, hyperinsulinemia and metabolic abnormalities is well recognized in both men and women. Recent data suggest that SHBG levels are an important predictor of cardiovascular disease (CVD) risk. Several methods have been used for the measurement of adiposity including ultrasonography (U/S) which is a reliable and low-cost method. We used U/S to assess regional adiposity and investigated possible associations with SHBG levels.</...

ea0056gp264 | Thyroid non cancer - Autoimmune Thyroid disease/pregnancy | ECE2018

Thyroid function in pregnant women; relation to Gestational Diabetes Mellitus (GDM) and Body Mass Index (BMI)

Simeakis George , Vogiatzi Evangelia , Konstantakou Panagiota , Zapanti Evangelia , Saltiki Katerina , Alevizaki Maria , Anastasiou Eleni

Objectives: The interplay between thyroid function and metabolic state has been studied in many population subgroups. For pregnant women thyroid and metabolic parameters, including glucose homeostasis, are of great importance for a successful outcome. We examined aspects of thyroid function in relation to GDM and BMI in pregnant women referred to our Department.Methods: We studied 520 women during 24th – 32nd gestation week. De...