Endocrine Abstracts

Case History: We present a case of a 52-year-old female with a history of right adrenalectomy at age 30, insulin-dependent Type 2 diabetes, and atypical clinical manifestations mimicking acromegaly. The patient presented with a five-year history of worsening facial appearance, blurry vision, and a noticeable hunch in the back. Notably, she had undergone right adrenalectomy for an adenoma in the past and had never received steroid therapy post-surgery. Despite presenting with f...

Case History: A 7 year old presented with 4 weeks of polyuria, polydipsia and one episode of nocturnal enuresis. The child’s past medical history was unremarkable, however, her parents reported that she was ‘less bright’ than her two siblings.Initial assessment: The child appeared well. Urine dipstick testing showed 3+ glucose. Blood glucose was 17.5, blood ketones were 0.4 and blood gas values were within the normal range.<p class="ab...

Insulinomas are rare, functional neuroendocrine tumours (NETs) that secrete excessive insulin. They are often diagnosed late due to their variable presentation and rarity. While predominantly solitary and benign, a minority of insulinomas can present as malignant. Insulinomas typically carry a hallmark clinical presentation characterised by Whipple’s triad; symptoms of hypoglycaemia (e.g., sweating, palpitations, headaches, confusion), documented low blood glucose levels ...

A 68-year-old woman presented with a several month history of nausea, confusion and generalised weakness. In addition, she reported decreased appetite with significant weight loss. She did not report any convulsions, abdominal pain, palpitations, or diarrhoea. Significant past medical history included well-controlled T2DM, hypertension, vitamin D deficiency and GI reflux disease. Importantly, she had no history of renal disease. Relevant medications incl...

A 68-year-old woman presented with a several month history of nausea, confusion and generalised weakness. In addition, she reported decreased appetite with significant weight loss. She did not report any convulsions, abdominal pain, palpitations, or diarrhoea. Significant past medical history included well-controlled T2DM, hypertension, vitamin D deficiency and GI reflux disease. Importantly, she had no history of renal disease. Relevant medications incl...

Introduction: Diaphoresis, or excessive sweating, is well recognised as a presenting complaint for endocrine disorders such as hyperthyroidism, acromegaly, and phaeochromocytoma. However, diaphoresis is an unusual presenting complaint for Cushing’s syndrome.Case: We present the case of a 35-year-old lady who first presented to health services for symptoms of excessive sweating, and feeling hot most of the time. Whilst initial investigations such as ...

Introduction: Graves’ disease is an autoimmune disorder which may lead to thyroid overactivity and eye disease. Oestrogen and progesterone are thought to be immunomodulatory and have been postulated to play an important role in the difference in prevalence of autoimmune disorders between men and women. Autoimmune disorders, including autoimmune thyroid disease, are often quiescent during pregnancy with an increased prevalence postpartum. The increase in immune mediated th...

Introduction: Bilateral adrenal tumours are rare and account for 10–15% of adrenal lesions. They can be infectious, inflammatory, tumour, hémmoragiques, and genetic. The clinical and imaging used to guide diagnosis.Aim: Assess clinical, etiologic, and therapeutic characteristics of bilateral adrenal masses.Population and methodology: This is a retrospective study of the records of patients with bilateral adrenal masses co...

Introduction: Congenital adrenal hyperplasia (CAH) are genetic diseases with a deficit of one of the enzymes of steroidogenesis (21 hydroxylase OH, 90%). The consequences of the adrenal hyperandrogenism that results are observed when the treatment is not undertaken precociously.Aim: To study the impact of CAH and or treatment by glucocorticoids on the final size and gonadal function in girls.Materials and methods: 25 patients with ...

Introduction: Intra-testicular adrenal inclusions (ISIT) are benign tumors made of ectopic adrenal cortex tissue hyper stimulated by ACTH in excess. All pathologies causing a rise ACTH levels may be associated with adrenal inclusions. They are found mainly in patients with congenital adrenal hyperplasia (CAH) of untreated or poorly treated.Objective: Search the frequency of ISIT in CAH and clarify clinical and progressive characteristics.<p class="ab...