Endocrine Abstracts

Background: Cardiovascular disease (CVD) is a leading cause of mortality. Childhood obesity is a major contributor to CVD. Atherogenic index of plasma (AIP) is an indicator of risk of atherosclerotic CVD. Associations between childhood obesity and CVD risk in the region remains under-explored. We aim to investigate this association as a predictor of CVD in this young population.Methods: Patients who attended our Centre (2009-2019), age ≤19 years an...

Background: The obesity prevalence surge in children and adolescents is associated with dysglycaemia, dyslipidaemia and long-term cardiovascular complications. Use of lipid-lowering medications1 has been recommended following lifestyle modifications. We aim to investigate the demographic, and changes in LDL-c, in these young patients, in the presence and absence of dysglycaemia.Methods: Complete lipid profiles of patients (≤19 years old)...

Introduction: We report the case of a patient with corticotropic insufficiency associated with diabetes insipidus who presented to the emergency room with profound hyponatremia; a complicated situation, whose solution was hidden in the galenic form of Desmopressin.Case report: Mrs Y. Amina, 37 years old, has been followed for 10 years for a non Langerhansian histiocytosis of pituitary location, complicated by a corticotropic insufficiency under hydrocort...

Introduction: Pituitary apoplexy is an acute infarction and/or hemorrhage of the normal or tumoral pituitary gland. It is a rare mode of revelation of pituitary adenomas, and the only situation where the pituitary adenoma can be complicated by a diabetes insipidus. Case report: Mrs Amina. Y, 54 years old, has been followed for 8 years for diabetes mellitus treated with metformin, and dyslipidemia under statins, presents in consultation for a severe polyu...

Background: Diagnostic work-up for Cushing Syndrome (CS) can be challenging and is based on clinical and biochemical assessments. Biochemical evidence of endogenous steroid excess is demonstrated through overnight dexamethasone suppression test (ODST), low dose dexamethasone suppression test and/or 24-hour urinary free cortisol estimation (UFC). Once endogenous steroid excess is confirmed, random serum ACTH measurement is key in determining the suspected source of steroid exce...

Introduction: Adrenal venous sampling (AVS) is widely used when investigating primary hyperaldosteronism. In this study we reviewed adrenal aldosterone and cortisol values for measurement range and for biochemical concordance with intervention in patients being investigated for aldosterone producing adenoma (APA).Methods: Retrospective review of AVS procedures performed at our institution during three years (May 2016–May 2019) was conducted. Aldoste...

Pheochromocytoma crises are uncommon but have high mortality. We describe herein a case where multidisciplinary team management was crucial in safely carrying the patient through such a crisis. The patient was a 63 year old lady with a background of neurofibromatosis type 1 (NF-1), and previous renal artery stenosis bypass surgery. She was admitted via A&E with increasingly frequent episodes of sweating, headache, dyspnoea and palpitations. Her troponin was raised at admis...

Background and aims: We previously reported BMI heritability in the UAE to be 39.9%; indicating a high (60.1%) contribution of environmental factors to obesity. This study aims to determine and compare co-twin monozygotic (MZ) and dizygotic (DZ) BMI concordances.Materials and methods: 200 twin pairs were identified (ICLDC patient database) and split into two age groups (≤18 and >18 years old). Opposite gender twin sets were considered DZ. In same g...

Introduction: Causes of Primary Congenital Hypogonadism in Males are Leydig cell Agenesis, Cryptorchidism, Chromosome abnormalities (e.g. Klinefelter syndrome, SRY positive 46 XX etc), Enzyme defects include 5α-reductase deficiency. Acquired Primary Hypogonadism includes Testicular torsion, Orchidectomy, Chemotherapy/Radiation toxicity, Orchitis, CKD, Cirrhosis, Sickle cell disease, etc. SRY (SEX determining region Y) is regulatory gene located on Y chromosome and is resp...

Case history: A 28-year-old female was investigated for hypocalcaemia. Her calcium level was checked because her mother was found to be hypocalcaemic post thyroidectomy for recurrence of Graves disease. Further detailed history taking revealed that the patient’s grandmother often complained of hand cramps on kneading dough. The patient’s aunt was believed to have a parathyroid disorder; no further details were available. On further investigation, it was apparent that...