Searchable abstracts of presentations at key conferences in endocrinology

ea0062p62 | Poster Presentations | EU2019

A case of a TSH-secreting pituitary macroadenoma in a previously well thirty year old woman

Golding Jonathan , Canagon Sara , Norris John , Chakera Ali

Case History: A thirty year old female presented to hospital after a first seizure. She had no significant past medical history. She had a one week history of recurrent frontal headaches and had noticed irregular periods. There were no clinical features of acromegaly. CT and MRI brain imaging showed a 5 cm mass arising from the pituitary fossa, extending into the suprasellar cistern and anterior cranial fossa. There was evidence of mass effect on the optic nerves and optic chi...

ea0062p68 | Poster Presentations | EU2019

The double edge sword steroid facilitated diagnosis of primary thyroid lymphoma

Ali Mudassir , Pervez Muhammed , Mounter Philip , Shanker Vivek , Kamaruddin Shafie

Introduction: Primary thyroid lymphoma (PTL) is a rare cause of malignancy, accounting for <5% of thyroid malignancies and < 2% of extra-nodal lymphomas. Most thyroid lymphomas are non-Hodgkin’s lymphomas of B-cell origin. Patients with Hashimoto’s thyroiditis are at greater risk for developing PTL. Early diagnosis is important as treatment and prognosis of PTL depend upon the histology and stage of the tumour at diagnosis. We report a rare case of primary th...

ea0062cb5 | Additional Cases | EU2019

The double edge sword steroid facilitated diagnosis of primary thyroid lymphoma

Ali Mudassir , Pervez Muhammed , Mounter Philip , Shanker Vivek , Kamaruddin Shafie

Introduction: Primary thyroid lymphoma (PTL) is a rare cause of malignancy, accounting for <5% of thyroid malignancies and < 2% of extra-nodal lymphomas. Most thyroid lymphomas are non-Hodgkin’s lymphomas of B-cell origin. Patients with Hashimoto’s thyroiditis are at greater risk for developing PTL. We report a rare case of primary thyroid lymphoma in a patient presenting with a rapidly enlarging thyroid goitre highly suspicious of anaplastic thyroid carcinom...

ea0063p1137 | Reproductive Endocrinology 2 | ECE2019

Clinical and para-clinical characteristics of Klinefelter syndrome diagnosed in adulthood

Khaldi Safa , Hasni Yosra , Sarra Dimassi , Ach Koussay , Saad Ali

Klinefelter syndrome (KS) is the most frequent sex chromosomal disorder and affects approximately one in 660 newborn boys. The phenotype is variable ranging from ‘nearnormal’ to a significantly affected individual. Typically, diagnosis is delayed with the majority of patients identified during fertility workup in adulthood, and only 10% of patients diagnosed prior to puberty.Patients and methods: This is an 8-year retrospective study of the cli...

ea0049gp29 | Adrenal 3 | ECE2017

Familial case of SDHB mutation presenting as a macroprolactinoma

Mills Edouard , Machenahalli Pratibha , Naqvi Ali , Todd Jeannie

Germline mutations in the succinate dehydrogenase subunit-B gene (SDHB) are well recognised for predisposing to head and neck paraganglioma, sympathetic paraganglioma, phaeochromocytoma and renal cell carcinoma. The co-existence with pituitary adenomas remains uncommon.We report a 31-year-old female who presented at age 29 years old with 9 months of secondary amenorrhoea. Prolactin was 3000 mIU/l and a 1.7-cm macroprolactinoma revealed on MR pituitary. T...

ea0049gp30 | Adrenal 3 | ECE2017

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia with cyclical ectopic adrenocorticotrophic hormone secretion

Machenahalli Pratibha , Mills E , Ali N , Todd JF

DIPNECH is pre-invasive precursor to carcinoid tumors and tmorlets, most of which present with pulmonary symptoms. We present a case of ectopic cyclical ACTH producing DIPNECH.33-year lady presented with a short history of weight gain, abdominal striae, proximal myopathy and secondary amenorrhoea. She reported a previous episode with similar symptoms one year earlier which resolved spontaneously after a few weeks. Random cortisol 4000 nmol/l, ACTH 98 ng/...

ea0049ep123 | Clinical case reports - Pituitary/Adrenal | ECE2017

The difficulty in predicting aggressive tumour behaviour of phaeochromocytomas

Mills Edouard , Naqvi Ali , Dina Roberto , Palazzo Fausto , Wernig Florian

Phaeochromocytoma and paragangliomas (PH/PG) are rare neuroendocrine tumours. Prediction of aggressive tumour behaviour remains a major challenge. The Phaeochromocytoma of the Adrenal gland Scaled Score (PASS) is used to separate benign from malignant lesions with a score > 4 showing potential for biologically aggressive behaviour. Pre-operatively, MIBG together with CT/MRI remain the diagnostic radiological gold standard.We report a 68-year-old fema...

ea0049ep419 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Is secreted frizzled-releated protein 4 (SFRP-4) a possible biomarker for β cell dysfunction?

Baldane Suleyman , Ipekci Suleyman , Abusoglu Sedat , Unlu Ali , Kebapcilar Levent

Introduction: SFRP-4 is a recently described inflammatory cytokine influencing insulin secretion from human β cells as an extracellular modulator of Wingless (Wnt) pathway. The aim of this study is to compare serum SFRP-4 levels in patients with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and type 2 diabetes (T2DM), and to investigate its relation with other parameters.Methods: The study included 152 patients who applied to the ...

ea0049ep964 | Pituitary - Clinical | ECE2017

Pregnancy in Cushing’s disease after treatment with surgery and cyber-knife radiosurgery

Oruk G Gonca , Olmezoglu Ali , Apaydin Melda , Guvenc Gonul

Women affected by Cushing’s disease (CD) are often infertile due to abnormal follicular development or anovulation. In these patients, first line treatment is pituitary surgery, which is effective in more than 83% of cases with microadenomas, but only in about 35% of those with macroadenomas. When surgery do not normalize circulating ACTH and cortisol concentrations, such drugs, e.g. ketoconazole or metirapone, and radiotherapy are used as adjuvant treatment. Concerning r...

ea0049ep1306 | Thyroid (non-cancer) | ECE2017

Audit of utility of radio-isotope scan in the investigation of thyrotoxicosis or subclinical hyperthyroidism and timing of anti-thyroid medication

Artham Satish , MacFarlane Heather , Ali Nishwa , James Andy

Thyrotoxicosis is one of the most common clinical problems in patients referred to endocrine clinic. TRAb is specific for graves disease (GD) and radioisotope scan (RIS) is useful diagnostic test in the investigation of thyrotoxicosis. RIS is commonly used when TRAb is borderline or negative to exclude thyroiditis.Aims and methods: To look at the use of RIS in the investigation of thyrotoxicosis and sub-clinical hyperthyroidism (SCH), and use of anti-thy...