Endocrine Abstracts

A 77 year old man with a background of Crohns disease requiring ileostomy, pernicious anaemia and hypertension, presented with a 4month history of dysphagia to solids, hoarseness of voice, anorexia and marked weight loss of 30 kg. He was initially referred to gastroenterology, who performed an endoscopy which was normal. Subsequently he was referred to the ENT and speech and language therapy departments. A video fluoroscopy confirmed severe oropharyngeal dysphagia with effortf...

A 27 year old lady with a background of Langerhans cell histiocytosis (LCH) presented to endocrinology clinic for investigation of thyrotoxicosis. At the age of three years old, she presented with a rash on her forehead, which on biopsy revealed Langerhans cell histiocytosis. She was also noted to have symptoms consistent with diabetes insipidus, for which she remains on desmopressin therapy. At the age of six she received pituitary radiotherapy and 6 years ago developed secon...

A 60year old gentleman was referred to endocrine team with new onset hyperthyroidism. He had developed tubulointerstitial nephritis secondary to carbamazepine resulting in ESRF 3 years previously. Four months prior to presentation he received a live-unrelated renal transplant including a single dose of Alemtuzamab post-operatively for induction of immunosuppression. Thereafter his immunosuppression was maintained with tacrolimus. Other medical history included bipolar disorder...

Introduction: Primary hyperparathyroidism affects 1% of the world’s population, with majority of cases due to benign parathyroid adenomas. Parathyroid cancer is a rare cause.Case report: This case report describes a 53-year-old lady presenting with nonspecific bone pains, whose initial workup revealed mild hypercalcemia and MRI lumbosacral spine suggestive of multiple myeloma. Subsequent work up, including two bone marrow examinations and serum prot...

A 31-year-old engineer presented with a 6-week history of tremor, weight loss, mild goitre and palpitations. At the onset of these symptoms, he also presented to a specialist eye hospital for difficulty with focussing his vision. He had no past medical history and was taking no medications. He did not have any family history of ocular or autoimmune conditions and was a non-smoker. On examination his BMI was 20, he had very mild proptosis, no diplopia and a diffuse symmetrical ...

A 47-year-old afrocaribbean lady was referred to endocrinology clinic with a 1-month history of weight loss, heat intolerance, palpitations, fatigue and hair loss. She reported symptoms consistent with proximal myopathy including myalgia and difficulty rising from chairs. Interestingly she noted a 1-month history of hypersalivation, which had caused her significant distress in her social and work life. The hypersalivation had resulted in a change in her voice and had also inte...

A 39-year-old rugby league player was admitted with back pain to an Endocrinology/General Medicine ward. He was diagnosed with osteomyelitis of the spine and was treated with antibiotic. During his prolonged in-patient stay (6 weeks i.v. antibiotic treatment), the presence of purple striae on his lower abdomen was noted. Although he did not have other classical features of a Cushing’s syndrome including proximal myopathy, he had an increased BMI (38 kg/m2) and ...

Background: Contrast procedures are frequently performed in diabetic patients and are the third most common cause of hospital-acquired renal failure1. Diabetic patients are at risk of Metformin associated lactic acidosis in the presence of renal failure2.Standards: RCR guidelines3 recommend:• Recent serum creatinine should be available for patients with renal disease or diabetes<p class="ab...

Introduction: Adrenocortical carcinoma (ACC) is an uncommon aggressive malignancy. Despite surgical resection, recurrence rates are high. Two areas of contention currently involve treatment of ACC: the role of laparoscopic surgery in removal of large, potentially malignant tumours and the role of Mitotane. We present a case of a large adrenal tumour, later confirmed as ACC, where initially laparoscopic adrenalectomy was considered, and adjuvant Mitotane has been given despite ...

Background and objectives: Goitre is still one of endemic health problems in Gorgan city after one decade of universal salt iodization in Iran. Hypothyroism have different complications in children that between them, developmental disorders of CNS are so important. This study proposed to determine that prevalence of thyroid function and volume disorders and its correlation with IQ in the mental retard (MR) children.Material and methods: This cross-sectio...