Endocrine Abstracts

Adrenal insufficiency is not commonly associated with a finding of bilateral enlarged adrenal gland when diagnosed in late adulthood. Various cases in the literature to date seem to indicate that the combination of these two findings may be suggestive of adrenal lymphoma. Our patient was initially referred to Gastroenterology with weight loss, nausea and early satiety from where he was referred for a whole body computed-tomography (CT) scan as part of a screen for malignancy. ...

Congenital adrenal hyperplasia (CAH) refers to an autosomal recessive condition due to 21 hydroxylase (21OHD) deficiency, is characterized by impaired biosynthesis of glucocorticoid and mineralocorticoid. The consequent increase in the ACTH leads to bilateral adrenocortical hyperplasia and hyperandrogenism. Nonclassic CAH (NCCAH) manifests with a less severe clinic that presents later in life with the sympthoms of excessive androgen production. Clinical features include premat...

Background: Pathophysiology of Diabetic retinopathy is a complex process. The aim of this study was to evaluate the association between insulin resistance, high sensitive CRP level as inflammation markers and diabetic retinopathy.Methods: In this cross-sectional, 342 patients with type 2 diabetes were selected. The following data were recorded: age, sex, duration of diabetes and type of medical treatment. HbA1c, FBS, HSCRP, lipid profiles and insulin lev...

Introduction: Papillary thyroid carcinoma is characterized by a good prognosis and a slow progression. Its metastases are usually located in cervical lymph nodes. But, sometimes they can reach the lung and bones. Cerebral metastases are exceptional as they have been reported in only 4%. Single or multiple, they can be totally symptomatic, but they are life threatening and require specific care as in the following caseCase report: A man aged 56, was refer...

GATA3 is a member of the family of zinc finger transcription factors that recognise (A/T)GATA(A/G) motifs in DNA, and mutations that lead to haploinsufficiency cause the hypoparathyroidism, deafness and renal dysplasia syndrome (HDR). GATA3 has two zinc fingers, of which the carboxy-terminal finger (ZnF2) is essential for DNA binding, whereas the amino-terminal finger (ZnF1) stabilizes this binding and physically binds with other multi-type zinc finger proteins, which are refe...

Background: Short synacthen(cosyntropin)test, has replaced the insulin stress test as the first-line test to assess adrenal insufficiency. The aim of this study, was to determine the utility of the 30 and 60 min cortisol measurement in the high dose (250 μg) short synacthen test.Methods: Cross sectional study was conducted by reviewing the database of patients underwent short synacthen test in Al-Faiha Diabetes Endocrine and Metabolism Center (FDEMC...

A 37-year-old woman presented to ED with abdominal bloating and pain. Ultrasound abdomen showed a viable single intrauterine pregnancy at 24 weeks of gestation. Patient was surprised of the diagnosis as she had longstanding premature ovarian insufficiency (POI). She had stage 3B Hodgkin’s disease (HD) diagnosed at 14 years of age when she had BEAM chemotherapy (Carmustine, Etoposide, Cytarabine and Melphalan) followed by autograft bone marrow transplant for recurrent dise...

Background: Adrenal vein sampling (AVS) is the gold-standard for localizing the site of autonomous aldosterone production in patients with primary aldosteronism (PA). The procedure is technically challenging with a reported success rate of 50-95%.Aim: To audit the success rate of AVS at a regional referral unit.Standards: No set standard exists. 80% success rate was taken as the minimum acceptable standard for a tertiary referral c...

A rare complication of thyrotoxicosis among Asians is Thyrotoxic Periodic Paralysis (TPP), with an incidence of approximately 2% in patients with thyrotoxicosis from any cause. TPP is characterized by sudden onset of hypokalemia and muscle paralysis. Hypokalemia in TPP results from an intracellular shift of potassium induced by the thyroid hormone sensitization of Na+ /K+ −ATPase rather than depletion of total body potassium. Treatment of TPP includ...

Subclinical hypothyroidism (SCH) represents a mild or compensated form of primary hypothyroidism. Although the relationship between SH and lipid profile have been reported in several studies, the results are conflicting. The objective of the present study is to assess dyslipidemia among patients with SCH. Our study included 107 patients vs 108 sex matched controls. Clinical information and medical history were obtained through a questionnary from all SCH patients and normal co...