Searchable abstracts of presentations at key conferences in endocrinology

ea0063p357 | Thyroid 1 | ECE2019

Association between vitamin D receptor gene polymorphisms and Graves’ disease: a systematic review and meta-analysis

Anagnostis Panagiotis , Veneti Stavroula , Adamidou Fotini , Artzouchaltzi Aikterini-Maria , Boboridis Kostas , Kita Marina

Introduction: The pathogenesis of Graves’ disease (GD) and Graves’ orbitopathy (GO) is not completely understood. On the other hand, vitamin D receptor (VDR) gene polymorphisms have been associated with susceptibility to a variety of chronic autoimmune diseases. The primary aim of this study was to synthesize the best available evidence regarding the association between VDR gene polymorphisms and risk of GD. Secondary aim was to search for their association with GO.<...

ea0063p522 | Calcium and Bone 2 | ECE2019

The effect of teriparatide on bone mineral density in a woman with severe lactation-related osteoporosis and multiple vertebral fractures

Anagnostis Panagiotis , Gkekas Nifon , Kenanidis Eustathios , Potoupnis Michael , Tsiridis Eleftherios , Goulis Dimitrios

Introduction: Lactation-related osteoporosis is a very rare entity, usually diagnosed with one or more fractures, during the early postpartum period. Due to the rarity of this condition, no consensus still exists with regard to thetype and optimal duration of treatment.Case presentation: A 39-year old Caucasian female was presented at the outpatient clinic in December 2016 for evaluation and management of severely low bone mineral density (BMD) and multi...

ea0049ep68 | Adrenal cortex (to include Cushing's) | ECE2017

The role of dehydroepiandrosterone sulphate (DHEAS) in the evaluation of autonomous cortisol secretion in adrenal incidentalomas

Adamidou Fotini , Georgiou Thomas , Mintziori Gesthimani , Tsirou Efrosini , Anagnostis Panagiotis , Panagiotou Athanasios , Kita Marina

Introduction: Subclinical hypercortisolism (SH) has been reported in 5–20% of patients with adrenal incidentalomas (AIs), with various cardiometabolic consequences. We intended to investigate the contribution of DHEAS to standard testing, as another indicator of autonomous cortisol secretion in AIs.Materials and methods: Ninety consecutive patients (n=90) with AIs were included in a prospective cohort study. SH was diagnosed if ≥2 cri...

ea0049ep828 | Thyroid (non-cancer) | ECE2017

Management of very severe Graves’ orbitopathy with low dose rituximab: report of two cases

Adamidou Fotini , Manani Christina , Anagnostis Panagiotis , Georgiou Thomas , Boboridis Kostas , Kita Marina

Introduction: Although Graves’ orbitopathy (GO) is common in the course of Graves’ disease, dysthyroid optic neuropathy and corneal breakdown are rare. We describe two cases of severe GO treated successfully with rituximab.Case 1: A 50-year-old female smoker with Graves’disease, presented with disfiguring eyelid edema, exophthalmos and diplopia, preserved visual acuity and clinical activity score (CAS) ≥ 5. She received pulsed medrox...

ea0049ep1084 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

The effect of hormone replacement therapy and tibolone on lipoprotein (a) concentrations in postmenopausal women: a systematic review and meta-analysis of randomized controlled studies

Anagnostis Panagiotis , Galanis Petros , Chatzistergiou Vasileia , Stevenson John , Godsland Ian , Lambrinoudaki Irene , Theodorou Mamas , Goulis Dimitrios

Introduction: Data on the effect of hormone replacement therapy (HRT) and tibolone on lipoprotein(a) (Lp(a)), an independent risk factor for cardiovascular disease, are heterogeneous and conflicting. The aim of this study was to investigate the effect of HRT and tibolone on Lp(a) concentrations in post-menopausal women.Methods/design: MEDLINE, Scopus, EMBASE and Cochrane databases were searched (up to February 2016). Two researchers identified randomized...

ea0049ep1471 | Thyroid (non-cancer) | ECE2017

Lateral cervical lymph node metastasis from papillary thyroid cancer of undetected primary: a case report

Panagiotou Athanasios , Adamidou Fotini , Anagnostis Panagiotis , Bobos Mattheos , Hatzibougias Dimitris , Tzelepi Keraso , Kita Marina

Background: Lymph node metastasis from papillary thyroid cancer without detectable primary within the thyroid gland is extremely rare. We describe a case of a young woman with a cervical metastasis, without detectable orthotopic or ectopic thyroid focus.Case report: A 30-year old woman with a history of adenocarcinoma of the ascending colon six years previously, presented at the 15th week of a normal second pregnancy, for management of subclinical Hashim...

ea0041ep30 | Adrenal cortex (to include Cushing's) | ECE2016

Do lipid profile predict subclinical Cushing’s Syndrome in patients with adrenal incidentalomas?

Mintziori Gesthimani , Georgiou Thomas , Siolos Athanasios , Adamidou Fotini , Efstathiadou Zoe , Anagnostis Panagiotis , Panagiotou Athanasios , Kita Marina

Introduction: Adrenal Incidentalomas (AIs) have been associated with an increased risk of metabolic syndrome and dyslipidemia, though evidence regarding the latter is limited and, sometimes conflicting. Lipid abnormalities in patients with AIs have been described to be associated with subclinical hypercortisolism. Our aim was to test if lipid profile in patients with adrenal incidentalomas may predict subclinical Cushing’s Syndrome (sCS).Material an...

ea0041ep108 | Bone &amp; Osteoporosis | ECE2016

Serum leptin, adiponectin and ghrelin concentrations in post-menopausal women: is there an association with bone mineral density?

Mpalaris Vasilios , Anagnostis Panagiotis , Anastasilakis Athanasios , Goulis Dimitrios , Doumas Argyrios , Iakovou Ioannis

Introduction: Adipokines and ghrelin exert well-documented effects on energy expenditure and glucose metabolism. Experimental data also support a role in bone metabolism, although data from clinical studies are conflicting. The purpose of this cross-sectional study was to investigate the association of serum concentrations of leptin, adiponectin and ghrelin with bone mineral density (BMD) in post-menopausal women.Methods/design: BMD in lumbar spine and f...

ea0041ep360 | Clinical case reports - Thyroid/Others | ECE2016

Pretibial myxedema in a euthyroid patient without history of autoimmune thyroid disease

Anagnostis Panagiotis , Artzouchaltzi Aikaterini , Grekou Alexandra , Stogiannou Dimitrios , Skalkou Anastasia , Gekas Nifwn , Gerou Spyridon , Tzalokostas Vasilios

Introduction: Pretibial myxedema (PM) is a rare extrathyroidal manifestation of Graves’ disease, with most patients being in hyperthyroid state. PM has also rarely been described in Hashimoto thyroiditis.Case report: A 61-year old Caucasian woman attended our outpatient dermatology clinic for evaluation and management of bilateral erythema, involving the lower two-thirds of the pretibial regions. She reported appearance of the same lesion 11 years a...

ea0037ep69 | Adrenal cortex | ECE2015

Prevalence and natural history of adrenal incidentalomas: a prospective cohort study

Anagnostis Panagiotis , Siolos Athanasios , Zouli Chrisanthi , Adamidou Fotini , Efstathiadou Zoe , Panagiotou Athanasios , Mintziori Gesthimani , Kita Marina

Introduction: Adrenal incidentalomas (AIs) are frequently detected due to the increasing use of abdominal imaging for diagnostic purposes. However, few prospective studies exist with respect to their natural history, regarding their size and clinical course. The aim of this study was to report the prevalence and natural history of AIs.Methods/design: Interim analysis of a prospective cohort study. The following tests were performed: serum cortisol noctur...