Searchable abstracts of presentations at key conferences in endocrinology

ea0030p30 | (1) | BSPED2012

Audit of diabetic ketoacidosis management in adolescents in paediatric and adult care settings

Ahmed Jannath , Srinivasan Ramesh , Anderson Mark , Agbeko Rachel

Introduction: Guidance on the management of diabetic ketoacidosis (DKA) has recently been updated in an effort to reduce the risk of complications, in particular, cerebral oedema. However, differences in recommendations for children and adults persist making the care of teenagers with DKA confusing and potentially hazardous.Aims: To compare the management of DKA in teenage patients in paediatric and adult care settings in the context of the latest nation...

ea0028p112 | Clinical practice/governance and case reports | SFEBES2012

Intrathyroidal parathyroid carcinoma: Putting the pieces together

Sivarajah Vernon , Anderson John , Berney Dan , Parvanta Laila

Parathyroid carcinoma (PTC) is a rare condition that lacks pathognomonic features, making diagnosis and therefore management challenging. In the very few cases of intra-thyroidal PTC reported, failure to achieve a pre-operative diagnosis has often led to unnecessary bilateral neck exploration and re-operation. We describe for the first time a case of intra-thyroidal PTC suspected pre-operatively. A 37-year-old Bangladeshi man presented with a 3-week history of mood changes, mu...

ea0025oc5.7 | Reproduction and fetal programming | SFEBES2011

Plasma biomarkers for early prediction of preeclampsia

Carty David , Anderson Lesley , Mcculloch Jim , Dominiczak Anna , Delles Christian

Introduction: Several biomarkers are elevated in late pregnancy in women with preeclampsia (PET), but none have been sensitive or specific enough to be used routinely in early pregnancy to predict the condition. We measured plasma levels of the anti-angiogenic peptides FMS-like tyrosine kinase 1 (sFLT-1), soluble endoglin (sENG), placental growth-factor (PGF), and an array of cytokines and adhesion molecules in early and mid pregnancy to assess their ability to predict PET.</p...

ea0025p101 | Clinical biochemistry | SFEBES2011

Thyroid storm in a teacup: an unusual presentation of thyrotoxicosis Category: clinical practice/governance and case reports

Blackmore Alexander , Anderson Iain , Mukherjee Annice , Doran Helen

A 43-year-old woman presented acutely with Graves disease and hyperthyroidism. She had thyroid eye disease and a large diffuse goitre with pressure symptoms. She reported hearing a bruit herself without a stethoscope. She was tachycardic, with capillary nail fold pulsation and a positive Pemberton’s sign. Initial T4 was 78.6, TSH not detected.Betablockers to control the patients tachycardia were contraindicated due to a history of asthma,...

ea0021oc2.6 | Neuroendocrine tumours/pituitary | SFEBES2009

Laying the foundation for neuroendocrine control of human reproduction: an investigation into the development of kisspeptin and neurokinin B networks

Tello Javier , George Jyothis , Millar Mike , Anderson Richard , Millar Robert

The development and maturation of kisspeptin neurons is critical for activating GnRH release needed to initiate puberty. However, little is known of the development and organization of kisspeptin neurons in the human hypothalamus and the anatomical architecture of kisspeptin neurons in rodents is distinct from that of primates.The aim of the present study was to examine the development of the hypothalamic neuroendocrine circuitry that sets the structural...

ea0017p44 | (1) | BSPED2008

Clinical challenges in children with Type I diabetes mellitus aged less than 6 years old in a UK region

Anderson Y , De Palma A , Widmer B , Ong K , Acerini C

Objectives: To assess current clinical practice in children aged 0–5.99 years with Type I Diabetes Mellitus (T1DM).Methods: All paediatric diabetes centres (n=17) within a single UK region were asked to provide retrospective data for the year ending 01/12/07. 15 (88%) centres responded and provided data for each child on presentation, initial and current insulin regimens. Outcome measures were HbA1c, and acute hospital admissions post-diagnos...

ea0010p76 | Steroids to include Cushing's | SFE2005

Free testosterone calculation: critical comparison of three equations and establishment of reference limits

Ho C , Stoddart M , Walton M , Anderson R , Beckett G

BackgroundSerum testosterone remains the most important investigation in the diagnosis of androgen deficiency in men. Most of the circulating testosterone is bound to albumin and sex hormone binding globulin (SHBG), whereas free testosterone accounts for approximately 2% of total testosterone. Because direct measurement of free testosterone is impractical in routine practice, several equations have been used to provide clinically useful estimates of free...

ea0008oc15 | Neuroendocrinology and Reproduction | SFE2004

PGF2alpha -FP receptor signalling is a potential regulator of endometrial vascular function

Sales KJ , Williams ARW , Anderson RA , Naor Z , Jabbour HN

Prostaglandin F2a (PGF) receptor (FP) expression is up-regulated in neoplastic epithelial and perivascular cells in endometrial adenocarcinomas, indicating potential regulation of vascular function by PGF via the FP receptor. This study investigated the potential role of PGF-FP receptor signalling in modulating vascular function in endometrial adenocarcinomas.Endometrial biopsies were obtained in accordance with Ethics Committee guidance with ...

ea0005p214 | Reproduction | BES2003

Investigating germ cell development and differentiation in the human fetal testis

Gaskell T , Robinson L , Anderson R , Saunders P

Testicular cancer has a peak incidence in young men between the ages of 15 and 40, with an increased frequency in individuals with disorders of the reproductive tract such as hypospadia and cryptorchidism. It has been proposed that carcinoma in situ cells are derived from testicular germ cells that have not differentiated appropriately during fetal life, perhaps as a result of disturbance of the hormonal environment. The aim of this study is to investigate whether estrogen may...

ea0003oc37 | Hormone Action | BES2002

Demonstration of progesterone receptor mediated gonadotrophin suppression in men

Brady B , Anderson R , Kinniburgh D , Baird D

Synthetic C19 gestogens which are used in combination with testosterone as hormonal contraception in men bind to both the androgen and progesterone receptor. The relative contribution of these two components is unclear. In this study, we have compared the effect of a synthetic gestogen (desogestrel) with naturally occurring progesterone on the pattern of secretion of LH and FSH in healthy volunteers. Twenty men aged 18-40 were randomised to receive either progesterone (gestone...