Searchable abstracts of presentations at key conferences in endocrinology

ea0009p3 | Diabetes and metabolism | BES2005

Low insulin-like growth factor-II (IGF-II) concentration predicts weight gain in normal weight subjects with type 2 diabetes

Heald A , Karvestedt L , Anderson S , McLaughlin J , Knowles A , Wong L , White A , Brismar K , Gibson M

IntroductionInsulin-like growth factors-I (IGF-I) and -II (IGF-II) are important in regulation of metabolism and growth. We previously reported in normal weight normoglycaemic individuals that low circulating IGF-II predicts future weight gain. We subsequently investigated whether such relationships persisted in circumstances of abnormal glucose tolerance.MethodIn 224 type 2 diabetes subjects we assessed the ...

ea0007p52 | Diabetes, metabolism and cardiovascular | BES2004

The IGF system influences prevalence of the metabolic syndrome in a population with high rates of cardiovascular disease

Heald A , Anderson S , Vyas A , Patel J , Siddals K , Cruickshank J , Gibson J

IntroductionThe metabolic syndrome is associated with an increased risk of cardiovascular disease and diabetes. The insulin-like growth factor (IGF) system has been implicated in the pathogenesis of cardiovascular disease and glucose intolerance. We have previously shown that a low IGFBP-1 concentration coupled with a low circulating IGF-I predicts worsening glucose tolerance. In this study we further investigated relationships between the IGF-system and...

ea0005p23 | Clinical Case Reports | BES2003

Cushing's disease in adolescence

Dale J , McGregor E , Johnson A , Toogood A , Shaw N , Anderson J , Stewart P

A 16-year-old boy was referred to our endocrine unit. He had been diagnosed with constitutional short stature (height <10th centile) aged 11, having not grown well for two years. At that time there were no features to suggest Cushing's syndrome (CS), though he was overweight (BMI 22kg/m2, >90th centile) and bone age was delayed by 2 years. A trial of growth hormone (GH) therapy did not increase growth velocity. By age 15, he was developin...

ea0005p210 | Reproduction | BES2003

Comparison between azoospermic responders and oligozoospermic non-responders to sex steroidal contraception: A pharmacogenetics study examining the androgen receptor, CYP17, LHbeta and 5alpha-reductase-2 genes

Oxynos C , Thakker N , Hewitt C , Southern L , Anderson R , Huhtaniemi I , Yong E , Wu F

BACKGROUND: Male steroidal contraceptive regimens achieve azoospermia in 60-90% of Caucasians. The mechanisms underlying this heterogeneity in response are not clear. The aim of this retrospective study was to examine a number of polymorphisms in genes involved in androgen metabolism and action, in azoospermic responders (n=73) and oligozoospermic non-responders (n=44) from previous contraceptive trials. METHODS: Local Ethical Committee approval was obtained. DNA was extracted...

ea0003oc5 | Genetics: New Insights into Endocrine Disease | BES2002

Identification of differentially expressed genes in rat chromosome 2 congenic strains

McBride M , Carr F , Graham D , Clark J , Strahorn P , Anderson N , Dominiczak A

Objective: To construct rat congenic strains to confirm and narrow down a region on rat chromosome 2 previously implicated in blood pressure regulation. To determine expression profiles and identify differentially expressed genes between congenic strain and respective parental strain using microarray technology.Design and Methods: Total RNA was prepared from whole kidney homogenates from 2x parental SHRSPGla and 2x SP.WKYGla2a congenic rats. Expression ...

ea0003p160 | Genetics | BES2002

Independent Y chromosome markers associated with blood pressure and testosterone levels

Charchar F , Tomaszewski M , Padmanabhan S , Lacka B , Anderson N , Zukowska-Szczechowska E , Grzeszczak W , Dominiczak A

Objective: To examine if there was an association between blood pressure and two polymorphic markers, M9 (CtoG) and HindIII in the non-recombining region of the Y chromosome.Design and Methods: 204 pedigrees all including hypertensive individuals were collected from the south of Poland after local Ethical committee approval. Phenotypic data including hypertensive status as well as BP, weight and height were collected. We phenotyped and genotyped 155 unr...

ea0003p226 | Reproduction | BES2002

Significant ethnic variation in circulating total bound and free testosterone

Heald A , Bethell F , Anderson S , Owen D , Laing I , Gibson J , Cruickshank J

OBJECTIVE Measurement of serum testosterone level is an integral part of the assessment of men presenting to endocrine clinics. Little is known about variation of testosterone level by ethnic group. The principal determinant of testosterone bioavailability is sex hormone binding globulin (SHBG) which itself is a marker for insulin sensitivity. Our aim was to examine variations in testosterone and SHBG levels across three ethnic groups in relation to ethnic differences in insul...

ea0056p724 | Clinical case reports - Pituitary/Adrenal | ECE2018

Two year old follow up of Hypophysitis secondary to the checkpoint inhibitor Pembrolizumab - a case report

Anderson Cian , Griffin James , McKenna Susan , Santos Ana , Westrup Jenny , Kelleher Fergal , Griffin Margaret

Ipilimumab (an anti-CTLA-4 antibody) treatment has been associated with Immune Related Adverse Events (iRAEs) of the endocrine system. However the frequency of iRAEs in programmed cell death (PD-1) receptor agent use is incompletely characterised, though initial studies report an incidence of 0.5%. We present a case of Pembrolizumab-induced hypophysitis in a 47 yo. male with melanoma. Presenting in 2007 with an initial diagnosis of melanoma, with lymph node recurrence in 2013....

ea0002oc4 | Vascular and Metabolic | SFE2001

The SF1 site polymorphism of the aldosterone synthase gene (CYP11B2) influences urinary steroid production and pressor dose response to angiotensin II during dietary manipulation of the renin-angiotensin system

Kennon B , Davies E , Ingram M , Friel E , Anderson N , Fraser R , Connell J

Background: A polymorphism within the CYP11B2 gene, characterised by a C/T substitution at position 344, the putative binding site for steroidogenic transcription factor1, has been shown to influence aldosterone excretion rate and blood pressure in essential hypertension.Aims: Assess the effect of contrasting genotype for the SF1 site on urinary and plasma steroid production during dietary manipulation of the renin-angiotensin system and assess the press...

ea0045p46 | Miscellaneous/other | BSPED2016

Blood pressure monitoring and management in young girls with turner syndrome

Murtaza Mohammed Ibrar , Anderson Ellen , Leighton Emma , Wong Sze Choong , Mason Avril

Background: Hypertension is common in adults with Turner Syndrome (TS) but less is known about hypertension in children with TS.Aim: To determine the frequency of hypertension in a contemporary paediatric TS cohort and to assess its association with clinical characteristics.Patients and methods: Preliminary analysis of 22 girls with TS attending a designated TS clinic at RHC, Glasgow, with at least 2 blood pressure measurements in ...