Endocrine Abstracts

Background: Often parathyroid indicentalomas (PI) in the form macroscopically enlarged single or multiple parathyroid glands are encountered during surgical thyroidectomy. The reported incidence in literature is variable (0.4–4.5%), but we feel its underreported compared to its frequency, as only less than 500 cases were reported thus far. Another enigma about PI is their clinical significance and natural history. In this context, we analysed our own experience and tried ...

Background: In 1985, Mikati et al., described a new syndrome, which included microcephaly, hypergonadotropic hypogonadism, short stature, mental retardation and minor anomalies in four out of nine siblings of consanguineous parents. No genetic disorder was associated to the disease. No further references to this syndrome have been found in literature. The authors present a new possible case of Mikati-Naijjar and Sahli syndrome (MNJS).Clinical case: Forty...

Endocrine cancer constitutes a term and simultaneously a definition of a type of cancer, that is common in American literature whereas so far absent in European nomenclature. Detailed analysis of scientific programs of European endocrinological and oncological congresses proves that also these societies do not mention this type of cancer. To change this unfavorable situation a new clinical platform called European Task Group for Endocrine Cancer (ETEC), working under the auspi...

Erdheim Chester disease (ECD) is a non langheransian rare histiocytosis, with around 500 cases described worldwide since its discovery for the first time in 1930 by Jakob Erdheim et William Chester. It is a multivisceral disease, characterized by a proliferation of abnormal histocytes CD68 positive and CD1a negative, including a retroperitoneal and perirenal fibrosis, a peri-aortitis, an osteosclerosis of the lower limbs and sometime an exophthalmia or an diabetes insipidus. H...

The 1-mg overnight dexamethasone suppression test (DST) is a screening test for endogenous Cushing’s syndrome (CS). The principle is that dexamethasone (D) will suppress ACTH and cortisol (C) secretion in healthy individuals, but not in CS. We have studied the associations between D and C concentrations in patients without CS after 1-mg DST.Methods: On suspicion of CS, 59 patients received 1-mg D at 23 p.m. and next day at 8 a.m. blood was drawn for...

Numerous hormonal and metabolic disorders caused by thyrotoxicosis lead to serious complications, so early diagnosis and adequate treatment becomes very important in warning of functional and organic changes in several organ systems, particularly in the structure of bone tissue.The aim was study of the effectiveness of calcium and alendronate for prevention and treatment of BMD losing in experimental models of thyreotoxicosis.Mater...

Introduction: G protein coupled receptor dimerization is proposed to have great impact on receptor signaling. Allosteric communication between the protomers of a dimer can alter ligand binding, receptor conformation and the interactions with different effector proteins. Although the concept of intradimeric interactions is widely accepted, the molecular mechanism behind them is not clearly understood. In this study we investigated the allosteric interactions within the type I a...

Introduction: In 1960, Van Wyk and Grumbach described the association of hypothyroidism and precocious puberty. Hypothyroidism leads to delayed bone age and a reduction in growth rate by reducing the amplitude of GH pulses. When precocious puberty is associated with thyroid hypofunction, estrogen action on the epiphyseal plates reduce this delay. We report the case of a child who developed incomplete puberty and reduced growth rate, caused by primary hypothyroidism.<p clas...

Mitochondria oxidize food substrates to generate energy for cellular work and heat is variably generated depending on the degree of coupling of electron transport to oxidative phosphorylation (OXPHOS). It has been hypothesized that climatic pressures exerted selection for mitochondrial haplogroup in arctic populations for a lower coupling of mitochondrial respiration to ATP production in favor of heat production. In this study muscle mitochondrial function was studied in Inuit...

Introduction: Although skin tag is associated with diabetes mellitus, no data in the literature show that the presence of skin tag is associated with diabetic macro and microangiopathy. The purpose of this study was to investigate frequency of hypertension, dyslipidemia, obesity, macro and micro angiopathy in type 2 diabetic patients with and without skin tag.Methods/Design: We evaluated 99 (40 female and 59 male) type 2 diabetic patients. All patients w...