Endocrine Abstracts

Introduction: Measles virus infections generally occur in childhood, but infections in adolescence and adulthood can lead to complications.Case report: A previously well 28-year-old woman had suffered from nausea, vomiting and generalized fatique for one day before being transferred to our emergency department in a confused state. A diagnosis of type 1 diabetes mellitus (T1D) complicated by ketoacidosis was made based on markedly decreased serum C-peptid...

Background and aims: The distribution of arterial occlusive disease is not fully explained in diabetes. The aim of this study was to examine the prevalence of CHD and PAD in diabetic patients complicated by abnormal test of distal autonomic function (Neuropad®) and large fibre neuropathy.Materials and Methods: 237 patients were analysed, M/F 111/126, age (mean±SD) 61.3±9.5years (ys), diabetes duration 16.4±10.6ys., type 1 n=22 (9.3%),...

Neuroendocrine tumors are rare in young patients and usually have favorable course. We present a case of young, 13-year-old girl diagnosed with insulinoma. The diagnosis was stated on the basis of the presence of neuroglycopenic symptoms. An abdominal CT scan demonstrated a tumor localized in the head of pancreas. The patient received diazoxide as a preparation to surgery. Therapy was effective, but discontinued due to side effects. Patient underwent the Whipple operation. Dur...

Background: Ketoconazole is a synthetic antifungal drug, and powerful inhibitor of steroidogenesis. Oral ketoconazole blocks both ovarian and adrenal androgen biosynthesis, and glucocorticoid synthesis, leading to a reduction in circulating testosterone and cortisol levels. In subjects with an intact HPA axis, ketoconazole by decreasing cortisol levels leads to compensatory rise an ACTH level.Objectives: To assess influence ketoconasole induced changes i...

Introduction: GDF-15 and TGF-β1 are growth factors involved in immune modulation and development of arteriosclerosis. Aim of this study was to assess whether GDF-15 and TGF-β1 concentrations are higher in adipose vs non-adipose individuals and whether this indicates early immune modulation with higher risk of arteriosclerosis.Description of methods: We examined 84 healthy individuals: 38 non-obese (average age 24.9 years) with mean BMI of 20.5+...

Objective: To evaluate the effects of free fatty acids (FFAs) on the regulation of plasma and adipose tissue mRNA adiponectin expression in lean and obese subjects.Methods: Seven obese men (31.3±1.1 kg/m2) and eight lean men (21.3±0.4 kg/m2) were studied. Subjects received an Intralipid 20% infusion over 180-min with sodium heparin. Blood sampling and abdominal subcutaneous adipose tissue biopsy were taken before and after...

Background: Gonadotroph adenomas usually present as non-functioning pituitary adenomas.We describe a patient with a functioning gonadotroph adenoma presenting with ovarian hyperstimulation syndrome: an exceptionally rare presentation of pituitary disease.Case history: A 26-year-old female presented with a 10-year history of worsening lower abdominal pain, bloating, dysmenorrhea and irregular periods in 2006. She was found by ultrasound to have multiple o...

Adiponectin, is an adipocyte derived hormone possess insulin-sensitizing, antiatherogenic, and antiinflammatory properties. The aim of this study to evaluate adiponectin levels at acromegalic patients according to healthy subjects in relation with ecocardiographic findings. We included 30 subjects (15 male, 15 female) were diagnosed as acromegaly and 30 healthy (10 male, 20 female) subjects. Mean ages of both group were similar. Serum glucose, insulin, GH, IGF1 (insulin like g...

Introduction: Plurihormonality of pituitary adenoma can be defined as the ability to express more than one hormone. 1–30% of pituitary adenoma are plurihormonal. We describe a case of plurihormonal adenoma with GH and ACTH secretion and triple immunostaining for GH, ACTH and prolactin.Case report: A 40 years old patient presented with sudden weight gain central obesity, hypertension, menstrual disorders, acne, hirsutism suggesting hypercortisolism. ...

Background: Serum thyroglobulin (Tg) measurements are one of the main pillars of thyroid cancer follow-up, because of the high organ and disease specificity of Tg in athyrotic patients. However, 20–25% of patients have detectable serum anti-Tg auto-antibodies (TgAB), which might cause false low Tg measurements in immunometric assays (IMA). This can lead to significant challenges in patient management. Measurement of Tg by liquid chromatography-tandem mass spectrometry (LC...