Endocrine Abstracts

Objective: To evaluate the effects of free fatty acids (FFAs) on the regulation of plasma and adipose tissue mRNA adiponectin expression in lean and obese subjects.Methods: Seven obese men (31.3±1.1 kg/m2) and eight lean men (21.3±0.4 kg/m2) were studied. Subjects received an Intralipid 20% infusion over 180-min with sodium heparin. Blood sampling and abdominal subcutaneous adipose tissue biopsy were taken before and after...

Background: Gonadotroph adenomas usually present as non-functioning pituitary adenomas.We describe a patient with a functioning gonadotroph adenoma presenting with ovarian hyperstimulation syndrome: an exceptionally rare presentation of pituitary disease.Case history: A 26-year-old female presented with a 10-year history of worsening lower abdominal pain, bloating, dysmenorrhea and irregular periods in 2006. She was found by ultrasound to have multiple o...

Adiponectin, is an adipocyte derived hormone possess insulin-sensitizing, antiatherogenic, and antiinflammatory properties. The aim of this study to evaluate adiponectin levels at acromegalic patients according to healthy subjects in relation with ecocardiographic findings. We included 30 subjects (15 male, 15 female) were diagnosed as acromegaly and 30 healthy (10 male, 20 female) subjects. Mean ages of both group were similar. Serum glucose, insulin, GH, IGF1 (insulin like g...

Introduction: Plurihormonality of pituitary adenoma can be defined as the ability to express more than one hormone. 1–30% of pituitary adenoma are plurihormonal. We describe a case of plurihormonal adenoma with GH and ACTH secretion and triple immunostaining for GH, ACTH and prolactin.Case report: A 40 years old patient presented with sudden weight gain central obesity, hypertension, menstrual disorders, acne, hirsutism suggesting hypercortisolism. ...

Background: Serum thyroglobulin (Tg) measurements are one of the main pillars of thyroid cancer follow-up, because of the high organ and disease specificity of Tg in athyrotic patients. However, 20–25% of patients have detectable serum anti-Tg auto-antibodies (TgAB), which might cause false low Tg measurements in immunometric assays (IMA). This can lead to significant challenges in patient management. Measurement of Tg by liquid chromatography-tandem mass spectrometry (LC...

Introduction: Apart from pulmonary and bone localizations, distant metastases from well differentiated thyroid carcinomas are very rare. Among them the adrenal ones are exceptional, and have generally a poor prognosis. The proof of the thyroid origin is not easy except if there is a histological confirmation by a CT guided biopsy of the adrenal tumor as in this observationObservation: A woman aged 56 was referred to our unit for pulmonary metastases of a...

Background: Nicotinamide phosphoribosyltransferase (NAMPT)/PBEF/visfatin is a widely expressed cytokine with various effects on glucose and lipid metabolism, cell survival, and inflammation. Despite a favorable body composition profile, acromegalic patients present insulin resistance, increased cardiovascular risk, and higher incidence of secondary tumors.Aim: Based on its relation to glucose and lipid metabolism and inflammation we hypothesized that NAM...

Two nationwide surveys on acromegaly (AcroBel-1 and 2) have been performed in Belgium at an interval of five years, including centralized GH and IGF1 measurements in most patients. A normal IGF1 for age was observed in 56% of 311 vs 74% of 365 treated patients, in 2004 and 2009 respectively.Factors responsible for this improvement were investigated. A selection bias was unlikely as the follow-up rate was higher in patients with active (83%) or medically ...

Pregnancy is associated with an increased risk of tumor growth in macroprolactinoma leading to discuss surgery in such cases.Objectives: Impact of pregnancy on prolactin secretion and tumor growth in a cohort of women with macroprolactinoma, including large tumors >20 mm, and medically treated.Methods: Retrospective study of all the women with macroprolactinomas diagnosed in two university hospitals, treated by dopamine agonist...

Objective: Many studies suggest that thyroid function modifies the process of healthy aging in humans. However, both a progressive increase and decrease of TSH with advancing age have been reported. The discrepancy may lie in the iodine intake in the population under, since low iodine intake results in an inverse association of TSH with age, while high iodine intake results in a positive association. We aimed to investigate whether FT4, FT3 and FT3</...