Searchable abstracts of presentations at key conferences in endocrinology

ea0024oc3.3 | Oral Communications 3 | BSPED2010

Are there practical alternatives to the inpatient mixed meal tolerance test for patients with Type 1 diabetes?

Besser R E J , Jones A G , McDonald T J , Shields B M , Knight B A , Hattersley A T

Introduction: Stimulated serum C-peptide (sCP) during a mixed meal tolerance test (MMTT) is the gold standard measure of endogenous insulin secretion in Type 1 diabetes (T1D). However invasiveness of sampling, the need to discontinue insulin prior to testing and rapid processing of samples limits its widespread use, particularly in children. Practical alternatives would increase utility.Aims: To assess if in a MMTT: 1.It is necessary to omit insulin. 2. ...

ea0019oc8 | Young Endocrinologist prize session | SFEBES2009

Quality of life (QoL) in male and female patients with congenital adrenal hyperplasia (CAH) compared to healthy subjects and patients with primary adrenal insufficiency

Bleicken B , Hahner S , Loeffler M , Ventz M , Allolio B , Quinkler M

Objective: There is evidence that current replacement regimens fail to restore well-being in patients with primary adrenal insufficiency (PAI). Few data is available on QoL in adult male and female patients with CAH.Methods: Patients with CAH or PAI were contacted and received a disease specific questionnaire and three standardized questionnaires (SF-36, GBB-24 and HADS). Reference data for SF-36 scores were obtained from the German National Health Surve...

ea0014p529 | (1) | ECE2007

Non-NMDA glutamate receptor antagonist injected into the mesencephalic dorsal raphe nucleus inhibits the suckling-induced prolactin release and administered into the lateral cerebral ventricle interferes with the diurnal fluctuations of plasma prolactin of male rats

Bodnár Ibolya , Bánky Zsuzsanna , Halász Béla

We examined the functional significance of the glutamatergic innervation of the dorsal raphe nucleus (DR) in the mediation of the suckling stimulus inducing prolactin release. A non-NMDA (6-cyano-7-nitroquinoxaline-2,3-dione disodium, CNQX) or an NMDA glutamate receptor antagonist (dizocilpine hydrogen malate, MK-801) was injected into the DR of freely moving lactating rats at the end of 4 h separation. The litters were then returned and blood samples for prolactin were taken ...

ea0011oc21 | Clinical endocrinology | ECE2006

Adjuvant radiation therapy of the tumor bed prevents local recurrences in adrenocortical carcinoma

Fassnacht M , Hahner S , Polat B , Koschker AC , Flentje M , Allolio B

Objective: Local tumor recurrence is common in adrenocortical carcinoma (ACC) and the most frequent cause for re-operation. Therefore, a concept for an adjuvant treatment is urgently needed. The role of radiotherapy in ACC has not been well defined and many authors have considered radiotherapy as ineffective. However, two studies with a small number of patients (n=3 and n=4, resp.) have suggested adjuvant radiation as an effective treatment to prevent recurrence ...

ea0011p218 | Cytokines and growth factors | ECE2006

The role of IL-4 and IFN-gamma as prognostic factors of major adverse cardiac events in patients with ST-elevation myocardial infarction assigned primary percutaneous coronary intervention

Osuch M , Szygula-Jurkiewicz B , Szkodzinski J , Wojnicz R , Lekston A , Polonski L , Blazelonis A , Zubelewicz-Szkodzinska B

Mediators of inflammatory reaction are present at every stage of forming of atheromatous plaque, its proliferation and destabilization. Cytokines play a key role in regulation of intensity of chronic inflamatory reaction. We aimed at investigation if IL-4 and IFN-gamma are predictors of MACE in a group of patients with acute myocardial infarction (AMI).A total of 50 patients: 40 males and 10 females, aged 56±10 years (mean±S.D.),...

ea0011p341 | Diabetes, metabolism and cardiovascular | ECE2006

Lipid profile in normal weight and obese women with polycystic ovary syndrome

Stojkovic M , Zarkovic M , Ciric J , Beleslin B , Savic S , Drezgic M , Trbojevic B

Background: Women with polycystic ovary syndrome (PCOS) appear at increased cardiovascular risk due in part to a dyslipidemia characterized by increased plasma triglyceride and reduced high density lipoprotein (HDL) cholesterol levels. Obesity, insulin resistance and hyperandrogenemia are features of PCOS and potentially affect lipid metabolism. On the other hand, obesity has an important influence on the lipid metabolism.Objectives: The aim of this stud...

ea0011p494 | Endocrine tumours and neoplasia | ECE2006

Daily profiles of aldosterone secretion in primary aldosteronism

Ciric J , Zarkovic M , Beleslin B , Penezic Z , Stojkovic M , Savic S , Trbojevic B

In supine subjects aldosterone daily variations are determined by spontaneous PRA rhythmicity and ACTH secretory bursts. The aim of this study was to analyze diurnal and pulsatile aldosterone secretion in two patients with primary aldosteronism (PA): a 33-year-old woman with aldosterone producing adenoma (APA) and a 40-year-old woman with idiopathic adrenal hyperplasia (IAH). Blood samples were taken hourly during 24 hours at the time of the diagnosis and three months later, a...

ea0011p500 | Endocrine tumours and neoplasia | ECE2006

Development of dopamine agonist resistance and progression from microadenoma to macroadenoma in two women with hyperprolactinaemia

McCall D , Hunter SJ , Cooke RS , Herron B , Sheridan B , Atkinson AB

Dopamine agonist therapy is an effective long-term treatment in >90% of patients with hyperprolactinaemia, controlling both prolactin secretion and tumour growth. We describe the unusual late emergence of resistance to high-dose dopamine agonist treatment in two recent female patients. Both women presented with secondary amenorrhoea, were shown to have high prolactin levels and a pituitary microadenoma. Each had an excellent initial response to bromocriptine but years late...

ea0011p567 | Growth and development | ECE2006

Lipid peroxidation, activity of caspase 3 and apoptosis activation in low birth weight children

Barg E , Gasiorowski K , Wikiera B , Skoczynska A , Turczyn B , Glab E

Children born with low birth weight (LBW, below 2500 g) exhibit slower development with deficit of height and, in adulthood, an increased risk of developing syndrome X. One possible explanation could be an enhanced elimination of cells by apoptosis. The aim of this study was evaluate of mechanism of lipid peroxidation and activity of caspase 3 in children with low birth weight.Subjects for study were 10 children with LBW and growth retardation (SDSHV&#60...

ea0011p592 | Neuroendocrinology and behaviour | ECE2006

Appetite regulating hormones in constitutionally lean and anorexia nervosa subjects

Galusca B , Germain N , le Roux CW , Frere D , Ghatei MA , Bloom SR , Estour B

Energy balance is controlled by the arcuate nucleus through integration of peripheral hormonal signals such as leptin, ghrelin, peptide YY (PYY) and glucagon like peptide 1 (GLP-1). The commonest reason for young women in the developed world to be underweight is restrictive anorexia nervosa (AN). Constitutionally thinness (CT) has been described in young women who satisfies the WHO definition for moderate to severe underweight (BMI 13–16.9 kg/m2). CT women have...