Searchable abstracts of presentations at key conferences in endocrinology

ea0011p623 | Neuroendocrinology and behaviour | ECE2006

Influence of affective changes on cortisol response to ACTH

Zarkovic M , Ciric J , Beleslin B , Penezic Z , Stojkovic M , Savic S , Trbojevic B

In this study we wanted to assess whether affective changes influence cortisol response during low dose (1 microgram) ACTH test. Beck Inventory of Depression and Hamilton Anxiety Rating Scale and low dose ACTH test were performed in five subjects during the prolonged psychological stress induced by war and 18 months later. After the war, Beck Inventory of Depression and Hamilton Anxiety Rating Scale scores were significantly reduced. Suppression of the HPA axis was present dur...

ea0011p661 | Reproduction | ECE2006

Hormone replacement therapy in postmenopausis fails to normalize gonadotropins – does it matter?

Zmire J , Cvitkovic P , Jukic P , Colak B , Lucinger D , Sokolic L , Rocic B , Kljajic K

Level of pituitary trophic hormone dictates dose of hormone replacement (HRT) in endocrine gland hypofunction. We examined 28 women receiving HRT in postmenopausis aged 46–63 yrs (54±4.27 yrs). In average patients started HRT two years after last spontaneous menstrual bleeding (28±3.76 months, 1–132 months). 8 patients used transdermal estradiol, 10 peroral combination of estradiol, estriol and norethisterone and 10 patients were treated by fixed peroral co...

ea0057006 | TAOK3 as a regulator of glucose tolerance in obesity | BES2018

TAOK3 as a regulator of glucose tolerance in obesity

Maes B , Fayazpour F , Catrysse L , Lornet G , Lapauw B , Lambrecht BN , Janssens S

Aims or Objectives: We here describe a role for the kinase thousand and one kinase (TAOK) 3 as a modulator of insulin resistance. TAOK3 is one of three members of the TAOK family of kinases, which are classified within the Ste20-like kinases as mitogen activated protein kinase 4 kinases. TAOK3 was identified in a RNAi library screening in C. elegans as a target molecule that could revert an insulin resistance-like state induced by a daf-2 mutation (Devgen, Ghent). Mor...

ea0009oc21 | Oral Communication 3: Neuroendocrinology | BES2005

Adenosine expression and function in the anterior pituitary gland

Francis K , Pexa A , Lewis B , McNicol A , Jasani B , Deussen A , Scanlon M , Rees D , Ham J

The nucleoside adenosine is an important regulator of interleukin-6 secretion from the folliculostellate (FS) cells of the anterior pituitary gland but the source of adenosine in this scenario is unknown. Therefore the aim of this study was to investigate secretion of adenosine and the expression of adenosine forming and metabolising enzymes in the pituitary gland.Ecto-5/-nucleotidase (CD73), adenosine kinase and adenosine deaminase (AD) were ...

ea0009p50 | Growth and development | BES2005

Nebivolol inhibits spontaneous and oxytocin-induced contractions in the rat uterus

Kavak B , Simsek M , Kutlu S , Ozcan M , Kumru S , Yilmaz B , Kelestimur H

Nebivolol is a recently developed beta(1)-selective adrenergic receptor antagonist with proposed nitric oxide mediated vasodilating properties. Effect of nebivolol on vascular smooth muscle has been attributed to estrogen receptor-mediated vascular responsiveness. Although it is known that nitric oxide has relaxing effect on myometrium, there is no report whether nebivolol application affect myometrial contractility. Therefore, we have investigated the effect of nebivolol on r...

ea0007p128 | Endocrine tumours and neoplasia | BES2004

Regional variations in colonic neoplasia in acromegaly

Ahmad B , Fazal-Sanderson V , Jewell D , Warren B , Turner H , Wass J

Introduction Some published studies suggest acromegalic patients have an increased risk of colonic tumours or pre-malignant dysplastic polyps. We assessed the prevalence of colonic polyps in Oxford acromegalic patients.Methods Patient database identified all 80 acromegalic patients who had had a colonoscopy.Control Patients Our data and published data on two autopsy and eight colonoscopic screening studies in asymptomatic non-acrom...

ea0005p223 | Steroids | BES2003

Excretion of the urinary metabolite of deoxycortisol is heritable and influenced by polymorphic variation at the CYP11B2 (aldosterone synthase) locus

Myosi B , Keavney B , Watkins H , Davies E , Ingram M , Fraser R , Connell J

Background: The enzymes 11beta-hydroxylase and aldosterone synthase are key control steps in regulation of cortisol and aldosterone synthesis. We have previously reported that polymorphic variation of the gene encoding aldosterone synthase (CYP11B2) is associated with altered efficiency of 11b-hydroxylation of the precursor of cortisol, deoxycortisol. In order to examine this relationship in greater detail, we have studied the pattern of steroid precursor metabolite excretion ...

ea0005p237 | Steroids | BES2003

Cortisol metabolite excretion and 11-hydroxysteroid dehydrogenase type 1 activity are strongly heritable in man

Myosi B , Watkins H , Keavney B , Ingram M , Fraser R , Davies E , Connell J

Background: Cortisol availability to target tissues represents a complex interplay of synthesis, secretion, metabolism and excretion. A number of these processes are regulated by enzymes that are encoded by genes that are key candidates in determining the metabolic and cardiovascular phenotype in man. Measurement of a range of corticosteroid metabolites allows the activity of these enzymes to be inferred. We have studied the pattern of cortisol metabolite excretion in a large ...

ea0004p43 | Diabetes, metabolism and cardiovascular | SFE2002

Hyperleptinemia and cardiovascular diseases

Sieminska L , Kajdaniuk D , Kos-Kudla B , Marek B , Nowak M , Szelag-Glogowska J

Hyperleptinemia is associated with such risk factors for cardiovascular disease as insulin resistance, obesity and hypertension. Recently, it has been identified that leptin has prothrombotic properties and increases the accumulation of oxidant radicals in endothelial cells. It is hypothesized that leptin may be also one of the mediators promoting atherosclerosis.The objectives of the work were to:determine whether there are any co...

ea0004p46 | Diabetes, metabolism and cardiovascular | SFE2002

Glucose intolerance in women with polycystic ovary syndrome

Sieminska L , Kos-Kudla B , Marek B , Kajdaniuk D , Foltyn W , Strzelczyk J , Staszewicz P

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age and is characterized by hyperandrogenism and menstrual disturbances. It is known that insulin resistance is associated with polycystic ovary syndrome and with obesity.The objective of this study was to assess the prevalence of glucose intolerance and diabetes in women with PCOS and to examine the role of body mass index in the development of this complications...