Searchable abstracts of presentations at key conferences in endocrinology

ea0008s28 | Neuroendocrine Tumours | SFE2004

Surgical Aspects of Medullary Thyroid Cancer Treatment

Harrison B

Adult and paediatric patients with Medullary Thyroid Cancer (MTC) may present in a variety of clinical scenarios. These include patients with a neck mass and 'apparently' sporadic disease or the index case of genetically determined disease (MEN2A/2B or FMTC), individuals from known MTC kindred who may be symptomatic or screen detected (either gene positive with an elevated basal / stimulated calcitonin, or gene positive and normocalcitonaemic) and patients with recurrent disea...

ea0005s22 | The Adipocyte as an Endocrine Organ | BES2003

Nuclear receptors in metabolic control

Staels B

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors activated by fatty acids and derivatives. While PPARalpha mediates the hypolipidemic action of fibrates, PPARgamma is the receptor for the antidiabetic glitazones. PPARalpha is highly expressed in tissues such as liver, muscle, kidney and heart, where it stimulates the b-oxidative degradation of fatty acids. PPARgamma is predominantly expressed in adipose tissues, where it promotes adipocyte differentiat...

ea0004s11 | Ageing and cellular senescence | SFE2002

Role of Oxidative Stress in Ageing

Merry B

It is considered that reactive oxygen species (ROS) and free radicals in general, are involved in a variety of physiological and pathological processes including degenerative disease and probably ageing. Age-related accrual of oxidative stress is a balance between ROS-induced generation rates and the activity of antioxidant defence enzymes, tissue antioxidant concentrations, repair processes, chaperone protein activity and molecular and cellular turnover rates. End-point measu...

ea0003s19 | Differentiated Thyroid Cancer | BES2002

Improving the utility of fine needle aspiration biopsy of thyroid tumours

Haugen B

Fine needle aspiration biopsy (FNAB) has become the mainstay of thyroid nodule evaluation. While the overall accuracy of FNAB is excellent, an indeterminate or suspicious biopsy can pose a diagnostic and management dilemma. Fortunately, only 20-25% of indeterminate nodules are ultimately found to be malignant. Unfortunately, approximately 75-80% of patients undergo a surgical procedure that may have not been necessary. Recent advances in molecular diagnostics such as immunocyt...

ea0003p149 | Endocrine Tumours and Neoplasia | BES2002

Routine calcitonin measurement in management of thyroid nodules: A decision analysis approach

Shine B

Background: Calcitonin is a reliable marker for medullary thyroid carcinoma (MTC) and is useful in follow-up of patients with MTC. While fine needle aspiration biopsy (FNA) is very sensitive and specific for differentiated thyroid carcinoma (follicular and papillary lesions), it is less reliable for diagnosis of MTC. It has been proposed that calcitonin should be used in assessment of patients with thyroid nodules. We have calculated the costs of this strategy.<p class="a...

ea0002sp1biog | European Medal Lecture | SFE2001

European Medal Lecture

Vennstrom B

Björn Vennström, Karolinska Institute, Stockholm, Sweden AbstractBjörn Vennström obtained his PhD at Uppsala University in 1978. He then spent two years in Dr Michael Bishop's laboratory at UCSF, characterising the erbA and erbB proto-oncogenes. Back in Uppsala he showed that the v-erbB oncogene of the Avian Erythroblastosis Virus is necessary and sufficient for transformation of both hematopoetic ...

ea0002sp9 | The Endocrinology of Syndrome X | SFE2001

WE CAN CURE CUSHING'S SYNDROME, SO CAN WE CURE THE METABOLIC SYNDROME?

Walker B

In Cushing's Syndrome, elevated circulating cortisol levels are responsible for the association of central obesity, hypertension, insulin resistance, hyperglycaemia, and dyslipidaemia. Recent evidence suggests that there are subtle elevations in circulating cortisol concentrations amongst patients with hypertension and insulin resistance, and these are predicted by low birthweight suggesting that they may be programmed by events occurring in early life. In addition, there is e...

ea0090ep372 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

This study compared the impact of TGC beginning during surgery versus after surgery on postoperative adverse events in individuals undergoing heart surgery

Bharti B B , Sinha Ajay Kumar

Introduction: During the perioperative period, surgical operations put patients under a great deal of physical stress. The immune system produces cytokines and other immune mediators in response to this threat. Recent studies have shown that using insulin to regulate blood glucose can reduce systemic inflammation.Objective: The objective of this research was examined how postoperative intensive insulin treatment (IIT) affects the inflammatory response in...