Endocrine Abstracts

Pituicytoms is a very rare low-grade glioma of the neurohypophysis and can affect both the sellar and suprasellar regions. We describe a case of a suprasellar pituicytoma and mengioma of a patient admitted to our Clinic as a suprasellar tumor patient.Clinical presentation: A 55-years-old man with a history of persistent headache in the right frontal area for a period of 10 years prior to the admission as well as visual disturbances and decreased libido f...

Insulin delivery through oral route requires protein protection against gastric environment followed by intestinal absorption. Several approaches using colloidal carriers have been proposed to achieve such attempts. Examples are nanoparticles produced from lipid materials (mono, di and triacylglycerols, waxes, fatty acids), polymeric materials (poly acid lactic/glycolic co-polymers, poly-epsilon caprolactone) or from polysaccharides (hyaluronic acid, dextran sulphate, alginate...

Introduction: Reactive hypoglycaemia (RH) is a complex problem, with no definite treatment apart from lifestyle changes.Methods: We used Sitagliptin in two patients with RH, who had tried lifestyle changes for at least 2 years but without much effect. A gentleman with initial BMI of 31.4 kg/m2 and another lady of BMI 24.1 kg/m2 was treated with Sitagliptin 100 and 50 mg daily, in view of their weight and thereby volume of distributi...

The hypothalamic decapeptide, gonadotropin-releasing hormone (GnRH), is the key neuroendocrine regulator of mammalian reproductive development and function. GnRH binds to its target, the GnRH receptor (GnRHR), on pituitary gonadotropes to stimulate the synthesis and intermittent release of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulate gametogenesis and gonadal hormone synthesis. Thus GnRH, via the GnRHR, plays a piv...

The human pubertal development is a very complex biological process that can be influenced by multiple factors including the genetic ones. A growing list of genes has been implicated in the pathogenesis of the congenital isolated hypogonadotropin hypogonadism (IHH) pointing to the complexity of the genetic basis of this condition. These genes encode peptides, which are involved in the development and migration of GnRH neurons or in regulation of synthesis, secretion and action...

This cross sectional single centre study was performed at an endocrine center in northern India (latitude 29°42′N and longitude 77°02′E) to assess the prevalence of vitamin D deficiency in 234 symptomatic women presenting with musculoskeletal symptoms. The study was conducted during winter (Nov 2010–Jan 2011).Subjects were recruited from patients attending the OPD for various musculoskeletal symptoms. Inclusion criteria were sy...

Introduction: Sheehan’s syndrome presents with hypopituitarism of variable severity after parturition usually preceded by post partum hemorrhage. Recovery of lactotroph function after initial insult has not been reported in the literature.Case report: A 41-year woman delivered her 1st child in 1994 at the age of 25 years, complicated by profuse vaginal bleeding and received two blood transfusions at a city hospital. She had lactation failure ...

The pathophysiology of type 2 DM is complex and involves insulin resistance, pancreatic beta cell dysfunction and visceral adiposity. The levels of free fatty acids (FFA) increases in obese persons and diabetic patients. Elevated levels of FFAs may cause resistance and deficient insulin secretion. Our aim in this study was to investigate the change of FFA levels, glucose, insulin and triglyceride in fasting and postprandial state in 15 healthy controls and 45 diabetic patients...

Introduction: Prevalence of diabetic neuropathy is between 10 to 90% in different studies base on the method of it evaluation(clinical or paraclinical).Objective: Evaluation of frequency of diabetic polyneuropathy indiabetic persons in endocrinology clinic of mashad endocrinand metabolic research center based on symptoms,signs and electrodiagnostic study.Method: The study was cross-sectional; 110 diabetic patients were enrolled.pat...

Summary: To establish the relations of women’s sexual function with social factors and use of hormonal contraception.Methods: There has been performed a pilot study. 20–43 years old participants with regular menstrual cycles (22–35 days) were randomly selected and have been interviewed. The test group consisted of 113 women who use any of hormonal contraception method. The control group consisted of 51 women not using hormonal contraceptio...