Searchable abstracts of presentations at key conferences in endocrinology

ea0014me1 | (1) | ECE2007

Endocrine orbitopathy

Balázs Csaba

Graves’ orbitopathy or thyroid-associated orbitopathy is the most frequent extrathyreoidal manifestation of Graves’ disease with autoimmun mechanism which is still incompletely understood. The epidemiologic data provided evidence that sever, infiltrative orbitopathy is in 3–5% of patients, the quality of life is impaired even in individuals with mild form of this disease. The anti-TSH receptor and anti-eye muscle autoantibodies have been proved to be involved in...

ea0047oc26 | Spotlight on Prostate Cancer | Theranostics2016

177Lu-DKFZ-PSMA-617 therapy in metastatic castration resistant prostate cancer: safety, efficacy and quality of life assessment

Yadav Madhav , Ballal Sanjana , Tripathi Madhavi , Damle Nishikant , Bal Chandrasekhar

Purpose: The purpose of this study was to evaluate the efficacy and safety of a novel theranostic agent, 177Lu-DKFZ-PSMA-617 therapy in metastatic castration resistant prostate cancer (mCRPC).Methods: 31 mCRPC patients with progressive disease despite second line hormonal therapy and/or Docetaxel chemotherapy were recruited for the study. All patients underwent diagnostic68Ga-PSMA-HBED-CCPET/CT, prior to inclusion for therapy. Inclu...

ea0035p582 | Endocrine tumours and neoplasia | ECE2014

Eleven base pair (AACACTCTAGC) deletion of SDHB Ex-4 from c.325 to c.335 in the patient with malignant Vaginal Paraganglioma – A case report

Gupta Poonam , Khurana Madan Lal , Ammini A C , Bal C S

Background: Pheochromocytoma (PHEO) and paraganglioma (PGL) are the tumors of adrenal medulla and extra adrenal ganglia respectively. Most of these PHEO/PGL are benign and may become malignant, if remain undiagnosed/untreated for a longer time. Vaginal PGL are extremely rare. There is not much published literature on vaginal PGL.Objective: To carry out biochemical and genetic analysis of the patient with MIBG negative malignant vaginal PGL.<p class="...

ea0020p388 | Diabetes and Cardiovascular | ECE2009

Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

Uslu Sema , Kebapci Nur , Kara Mehmet , Bal Cengiz

Aims: In this study, we examined the relationships between levels of adipocytokines and traditional and non-traditional cardiovascular risk markers in patients with type 2 diabetes mellitus (T2DM).Methods: Serum leptin, resistin, adiponectin, visfatin, high sensitive C-reactive protein (hsCRP), homocystein, asymetric dimethylarginine (ADMA), fasting glucose, insulin, glycated haemoglobin (HbA1C) and full lipid and lipoprotein profile, systolic...

ea0015p42 | Clinical practice/governance and case reports | SFEBES2008

Audit of local management of primary hyperparathyroidism: would local guidelines aid management?

McGeoch Susan , Robertson Douglas , Bal Satinder , MacRury Sandra

Primary hyperparathyroidism is a common endocrine disorder. Diagnosis is more frequently made where calcium testing forms part of routine screening bloods. The clinical profile has shifted from a symptomatic disorder with hypercalcaemic symptoms, kidney stones and overt bone disease towards a more asymptomatic state. The National Institutes of Health (NIH) have produced guidelines on diagnosis and management of primary hyperparathyroidism but no UK guidelines are in existence....

ea0041ep301 | Clinical case reports - Pituitary/Adrenal | ECE2016

Acromegaly in a male patient with Kleinfelter syndrome

Burcak Polat Sefika , Bestepe Nagihan , Topaloglu Oya , Bal Ercan , Ersoy Reyhan , Cakir Bekir

Introduction: Klinefelter syndrome is known as the set of symptoms that result from two or more X chromosomes in males. There is no known association of this syndrome with GH hypersecretion. The most remarkable symptom is gigantism and it can also be observed in androgen deficient states as such as the Klinefelter syndrome and some more genetic syndromes such as the Sotos syndrome, the Marfan syndrome, the homocystinuria, and the fragile X-syndrome. Herein we presente...

ea0041ep938 | Pituitary - Clinical | ECE2016

Tolosa Hunt syndrome involving the pituitary: a case report

Polat Sefika Burcak , Topaloglu Oya , Bal Ercan , Ersoy Reyhan , Cakır Bekir

Introduction: Tolosa Hunt syndrome (THS) is described as unilateral orbital pain associated with paresis of one or more of the third, fourth and/or sixth cranial nerves caused by a granulomatous inflammation in the cavernous sinus, superior orbital fissure or orbit. Pituitary gland is rarely involved in this syndrome. Herein we represented a case with hypophysitis with Tolosa Hunt who was operated with the suspicion of pituitary adenoma.Case: A 63-year-o...

ea0035p580 | Endocrine tumours and neoplasia | ECE2014

Plasma free metanephrine, normetanephrine and 3-methoxytyramine for the differential diagnosis of pheochromocytoma and paraganglioma

Gupta Poonam , Khurana Madan Lal , Sharma S C , Bal C S , Ammini A C

Background: Pheochromocytoma (PHEO) and paraganglioma (PGL) of abdominal origin secrete catecholamines which are metabolized to metanephrines. Head-and-neck paraganglioma (HNPGL) are considered as non secretary tumors.Objectives: To find the utility of plasma free metanephrine (MN), normetanephrine (NMN) and 3-methxytyramine (3-MT) for the differential diagnosis PHEO/PGL after excluding MEN2 and VHL patients.Methods: A total of 79 ...

ea0032p1023 | Thyroid (non-cancer) | ECE2013

Prevalence of thyroiditis in ankylosing spondylitis patients

Bayram Korhan Baris , Harman Ece , Akcay Serkan , Bal Serpil , Arslan Banu

Objective: We aimed to evaluate the prevalance of thyroiditis in ankylosing spondylitis patients in this study. We investigated the role of serum procalcitonin as a chronic inflamatory marker in ankylosing spondylitis.Methods: Sixty-seven patients who diagnosed as ankylosing spondylitis according to American College of Rheumatology (ACR) criteria and 57 healthy controls were included in our study. Serum levels of procalcitonin, TSH, free triiodothyronine...

ea0056p419 | Diabetes complications | ECE2018

Urinary neutrophil gelatinase-associated lipocalin (NGAL) as a marker of diabetic nephropathy in type 1 diabetic patients

Sisman Pinar , Gul Ozen Oz , Dirican Melahat , Bal Ahmet Selim , Cander Soner , Erturk Erdinc

Aims: Glomerular and tubulointerstitial damage plays a role in renal function failure in diabetic patients. While both serum and urine levels of neutrophil gelatinase-associated lipocalin (NGAL) show significantly increased levels in acute renal pathologies, the NGAL increase in active phase indicates a reversible condition in chronic cases. In this study, we determined if urinary excretion of NGAL can be used as an early indicator of diabetic nephropathy, which causes chronic...