Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep1001 | Hot topics (including COVID-19) | ECE2020

Obstructive sleep apnea in primary aldosteronism is associated with cortisol cosecretion

Heinrich Daniel , Adolf Christian , Handgriff Laura , Schneider Holger , Nirschl Nina , Obster Elisabeth , Sturm Lisa , Wang Xiao , Bidlingmaier Martin , Wildgruber Moritz , Ladurner Roland , Beuschlein Felix , Reincke Martin

Background: Primary aldosteronism (PA) is a secondary form of arterial hypertension that – in case of unilateral disease – can be cured by surgery. Multiple studies have shown that PA patients are at higher risk to suffer from cardiovascular events and to develop metabolic diseases. Two thirds of patients with PA suffer from obstructive sleep apnea (OSA). A bi-directional, pathophysiological interplay between OSA and PA has been proposed, with focus on overnight ro...

ea0020p194 | Endocrine tumours and neoplasia | ECE2009

Impact of surgery on clinical outcome in patients with recurrence of adrenocortical carcinoma

Erdogan Ilknur , Hahner Stefanie , Johanssen Sarah , Fenske Wiebke , Quinkler Marcus , Willenberg Holger S , Beuschlein Felix , Brix David , Allolio Bruno , Fassnacht Martin

Introduction: The role of surgery for recurrent ACC is not well defined. Therefore, we used the German ACC Registry to evaluate treatment modalities after first recurrence in patients amenable to surgery.Methods: Patients with recurrence after radical resection and follow-up data were included. Patients with extensive metastasized disease (>2 tumoral organs, peritoneal carcinomatosis) were excluded. Progression-free and overall survival (PFS/OS) were...

ea0016s30.3 | Clinical highlights | ECE2008

[123I]Iodometomidate as a radiotracer for diagnosis of adrenal tumours and adrenocortical carcinoma

Hahner Stefanie , Schirbel Andreas , Kreissl Michael , Fassnacht Martin , Johanssen Sarah , Beuschlein Felix , Quinkler Marcus , Reincke Martin , Stuermer Andrea , Reiners Christoph , Allolio Bruno

Subject: Adrenal tumours (AT) are often detected incidentally and represent a variety of differential diagnoses with variable therapeutic consequences. We have recently developed [123I]Iodometomidate ([123I]IMTO), that specifically binds to adrenal CYP11B enzymes as a SPECT tracer for adrenal scintigraphy. This radiotracer is now evaluated in patients with adrenal tumours in an ongoing clinical trial. The study was approved by the ethical committee and pa...

ea0016p37 | Adrenal | ECE2008

The German Conn's registry: comorbidities in over 700 patients with primary hyperaldosteronism

Born-Frontsberg Eric , Schirpenbach Caroline , Hahner Stefanie , Beuschlein Felix , Bidlingmaier Martin , Diederich Sven , Lorenz R , Rump Lars , Seufert Jochen , Endres Stefan , Quinkler Marcus , Reincke Martin

Objective: Hypokalemic Conn’s syndrome is a rare disease with a prevalence of 0.5% in unselected hypertensive populations. However, recent studies indicate a higher prevalence of a milder variant of Conn’s syndrome, reaching 10% in some studies. Long term outcome and health care costs of hypo- and normokalemic variants are largely unknown. The National Conn’s Registry is an initiative to create a national database of sufficient epidemiological strength to invest...

ea0016p45 | Adrenal | ECE2008

Renal function in patients with primary aldosteronism: comparison with essential hypertension

Reincke Martin , Schirpenbach Caroline , Hahner Stephanie , Beuschlein Felix , Bidlingmaier Martin , Diederich Sven , Lorenz Reinhard , Rump Lars Christian , Seufert Jochen , Meisinger Christa , Holle Rolf , Quinkler Marcus

Objective: Primary aldosteronism (PA) is associated with vascular end organ damage. We evaluated the newly established German Conn’s Register for evidence of renal impairment and compared the data with renal function from hypertensive subjects from an epidemiologic cohort.Methods: The registry was founded in 2006 and has at present 7 participating centres in 5 locations. Data are entered in a central electronic database. Up to July 2007 555 patients...

ea0073oc11.2 | Oral Communications 11: Adrenal and Cardiovascular Endocrinoloyg | ECE2021

Extensive preclinical screening of chemotherapeutic agents and molecular targeted Inhibitors reveals potent combinatory treatment for adrenocortical carcinoma (ACC)

Bothou Christina , Sharma Ashish , Shapiro Igor , Adrian Oo , Kim Baek , Beuschlein Felix , Perge Pal , Igaz Peter , Ronchi Cristina L. , Hantel Constanze

Current systemic treatment options for patients with ACCs are far from being satisfactory. DNA damage/repair mechanisms, which involve e.g. ATM/ATR-signalling or RRM1/RRM2 encoded ribonucleotide reductase (RNR) activation commonly contribute to drug resistance. Moreover, also the regulation of RRM2b, the p53-induced alternative to RRM2, is of unclear importance for ACC. Upon extensive drug screening, including a large panel of classical chemotherapies (doxorubicin, etoposide, ...

ea0081oc6.1 | Oral Communications 6: Endocrine-Related Cancer | ECE2022

Recurrent disease in patients with sporadic pheochromocytoma and paraganglioma

Li Minghao , Prodanov Tamara , Meuter Leah , Kerstens Michiel , Bechmann Nicole , Prejbisz Aleksander , Fassnacht Martin , Timmers Henri , Beuschlein Felix , Fliedner Stephanie , Robledo Mercedes , Lenders Jacques , Pacak Karel , Eisenhofer Graeme , Pamporaki Christina

Background: It is well established that life-long follow-up is required for patients with hereditary pheochromocytomas and paragangliomas (PPGLs), due to the potential of developing recurrent disease. However, whether follow-up of patients with sporadic PPGLs is necessary, remains unclear.Aims: To examine the prevalence and predictors of recurrent disease in patients with sporadic PPGLs.Materials and method: This multicenter study included retrospective ...

ea0081oc13.2 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Early post-operative ACTH-stimulated aldosterone predicts long-term biochemical outcome in primary aldosteronism

Bruedgam Denise , Adolf Christian , Schneider Holger , Wegmann Verena , Schwarzlmueller Paul , Mueller Lisa , Holler Finn , Lechner Benjamin , Handgriff Laura , Ladurner Roland , Deniz Sinan , Williams Tracy Ann , Beuschlein Felix , Reincke Martin , Heinrich Daniel

Introduction: Primary aldosteronism (PA) is the most common surgically curable cause for endocrine hypertension. Patients with unilateral aldosterone-producing adenoma undergo adrenalectomy (ADX). Clinical and biochemical outcome is assessed 6-12 months after ADX according to PASO consensus. To reduce unnecessary follow-up visits and change in medication for diagnostic purposes for potentially cured patients after ADX, a prediction tool is needed. Previous research had shown g...

ea0065oc5.5 | Adrenal and Cardiovascular | SFEBES2019

Somatic transmembrane domain mutations of a cell adhesion molecule, CADM1, cause primary aldosteronism by preventing gap junction communication between adrenocortical cells

Wu Xilin , Garg Sumedha , Cabrera Claudia , Azizan Elena , Zhou Junhua , Mein Chaz , Takaoka Yutaka , Wozniak Eva , Zhao Wanfeng , Marker Alison , Buss Folma , Murakami Masanori , Beuschlein Felix , Reincke Martin , Ito Akihiko , Brown Morris

Background: Primary Aldosteronism (PA) is the commonest curable cause of hypertension. Whole exome sequencing (WES) of an aldosterone producing adenoma from a 46-year-old man with resistant hypertension revealed a novel somatic mutation (Val380Asp) of the single transmembrane domain of Cell Adhesion Molecule-1 (CADM1). A Gly379Asp mutation was identified by WES of a PA patient in Munich. Both patients were cured of hypertension by adrenalectomy.Method: A...

ea0063gp94 | Adrenal and Neuroendocrine - Basic | ECE2019

Somatic transmembrane domain mutations of a cell adhesion molecule, CADM1, cause primary aldosteronism by preventing gap junction communication between adrenocortical cells

Wu Xilin , Garg Sumedha , Cabrera Claudia , Azizan Elena , Mein Chaz , Takaoka Yutaka , Wozniak Eva , Zhao Wanfeng , Marker Alison , Buss Folma , Murakami Masanori , Beuschlein Felix , Reincke Martin , Ito Akihiko , Brown Morris

Background: PA is the commonest curable cause of hypertension. Whole exome sequencing (WES) in 2011 and 2013 identified common somatic mutations in genes regulating membrane polarisation in 60-80% of aldosterone-producing adenomas (APA). In search of the missing variants, we undertook further WES. One APA from a 46-year-old gentleman revealed a novel somatic mutation (Val380Asp); which introduced a charged amino-acid into the single transmembrane domain of Cell Adhesion Molecu...