Searchable abstracts of presentations at key conferences in endocrinology

ea0063p449 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Prevalence of neuroendocrine tumors in a subgroup of young patients: single center experience

Isailovic Tatjana , Macut Duro , Popovic Bojana , Ognjanovic Sanja , Kovacevic Valentina Elezovic , Milicevic Ivana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

Neuroendocrine tumors encompass a heterogeneous group of tumors arising from the diffuse neuroendocrine system. The incidence of NETs rises with age, with the peak after 65 years. However, all NETs observed in adults may be diagnosed in children too. There are a very few studies addressing NETs in young patients. This study summarizes clinical, histopatological and genetic characteristics of young patients with NETs. This is a retrospective study describing clinical, histopath...

ea0063p662 | Interdisciplinary Endocrinology 1 | ECE2019

Adaptation of hypothalamo-pituitary-adrenal axis and cardio-metabolic parameters to physical stress in professional athletes

Popovic Bojana , Macut Djuro , Popovic Dejana , Banovic Marko , Bozic Antic Ivana , Isailovic Tatjana , Ognjanovic Sanja , Bogavac Tamara , Elezovic Kovacevic Valentina , Ilic Dusan , Damjanovic Svetozar

Introduction: Although intensive, repeated and perennial, physical stress of training generally does not represent a health hazard to professional athletes. Adaptation to such stress is presumed on multiple levels, but still not fully defined. Our aim was to analyze specificities of hypothalamic-pituitary-adrenal (HPA) axis response and adaptation to physical stress in professional athletes.Subjects and methods: We exposed 55 professional male athletes t...

ea0063p806 | Thyroid 2 | ECE2019

The relation of thyroid autoimmunity and parameters of cardiac function

Bogavac Tamara , Macut Djuro , Antic Ivana Bozic , Popovic Bojana , Isailovic Tatjana , Elezovic Valentina , Ilic Dusan , Ognjanovic Sanja , Damjanovic Svetozar , Nikolic Marina Djurovic

Introduction and aims: Autoimmune thyroiditis represent a state predisposed for the development of hypothyroidism. It is known that subclinical and overt hypothyroidism are important risk factors associated with the development and progression of heart failure. These effects are due to the changes in the structure and function of the cardiac muscle, as well as the overall cardiac mechanics. The aim of our study was to examine the influence of autoimmune thyroiditis (Hashimoto ...

ea0063p1130 | Reproductive Endocrinology 2 | ECE2019

The metabolic effects of metformin, cyproterone-acetate and their combination in women with polycystic ovary syndrome

Bozic-Antic Ivana , Ilic Dusan , Bogavac Tamara , Erceg Snjezana , Lacmanovic Mirjana , Popovic Bojana , Isailovic Tatjana , Elezovic-Kovacevic Valentina , Ognjanovic Sanja , Vojnovic-Milutinovic Danijela , Macut Djuro

Introduction: Metformin and oral contraceptive pills (OCP) are the most commonly prescribed medications among women with polycystic ovary syndrome (PCOS). The aim of this study was to compare effects of pill containing cyproterone-acetate (CPA) and metformin (METF) in women with PCOS during six months of follow-up.Methods: Group of 60 women with PCOS diagnosed by ESHRE/ASRM criteria were divided into 3 subgroups (20 women each), which were treated with d...

ea0049gp139 | Female Reproduction | ECE2017

Sensitivity of hypothalamo-pituitary-adrenal axis in women with PCOS

Macut Djuro , Bozic-Antic Ivana , Bjekic-Macut Jelica , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Bogavac Tamara , Popovic Bojana , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja

Introduction: Increased adrenal androgen production is present in 20–60% of women with polycistic ovary syndrome (PCOS). Possible mechanism is not clarified yet and could be related to altered hypothalamic-pituitary-adrenal-axis (HPA) activity or a consequence of adrencortical steroidogenic abnormalities. The aim of the study was to assess HPA sensitivity in PCOS women using different doses of dexamethasone.Methods: We analyzed 359 women with PCOS d...

ea0049ep80 | Adrenal cortex (to include Cushing's) | ECE2017

The effect of subclinical hypercortisolism on bone mineral density in female patients with adrenal incidentalomas

Ognjanovic Sanja , Macut Djuro , Petakov Milan , Elezovic Valentina Kovacevic , Isailovic Tatjana , Antic Ivana Bozic , Ilic Dusan , Popovic Bojana , Bogavac Tamara , Antic Jadranka , Damjanovic Svetozar

To investigate the prevalence of SH and osteoporosis in female patients with unilateral AIs (UAIs) and bilateral AIs (BAIs).We enrolled 106 female patients, 68 (64.2%) with UAIs and 47 (35.8%) with BAIs. SH was diagnosed in the presence of serum cortisol levels after 2-day low-dose dexamethasone suppression test (LDDST) >50 nmol/l with at least one of the following parameter (midnight serum cortisol >208 nmol/L, 24-h urinary free cortisol >24...

ea0049ep166 | Endocrine tumours and neoplasia | ECE2017

Clinical characteristics and survival of patients with paraganglioma: a single center experience

Elezovic Valentina , Macut Djuro , Ognjanovic Sanja , Isailovic Tatjana , Popovic Bojana , Bozic-Antic Ivana , Bogavac Tamara , Ilic Dusan , Bankovic Jovana , Damjanovic Svetozar

Paragangliomas (PGLs) and pheochromocytomas (PCCs) are rare neuroendocrine tumors that derived from pluripotent neural crest stem cells. PCCs are derived from the adrenal medulla, while PGLs are histologically identical tumors derived from ganglia outside the adrenal gland. Even though the majority of tumors are benign, they are associated with high morbidity rates caused by excessive catecholamine secretion. We retrospectively analyzed 71 patients (36 female and 35 males) wit...

ea0049ep177 | Endocrine tumours and neoplasia | ECE2017

Pancreatic neuroendocrine tumors (PNETs) in patients with MEN1 syndrome

Isailovic Tatjana , Macut Djuro , Ognjanovic Sanja , Petakov Milan , Elezovic Valentina , Milicevic Ivana , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

PNETs represent the leading cause of mortality in MEN1 patients. Yet, their characteristics, behaviour, and therefore management, are still uncertain.The aim of this study was to describe the main clinical characteristics of NETs in MEN1, and to compare them with sporadic NETs.We investigated 164 patients with PNETs retrospectively, treated in one centre from 2004–2016. We identified 15 (9.1%) patients with MEN1. All patients ...

ea0049ep191 | Endocrine tumours and neoplasia | ECE2017

Biology and differential diagnosis of calcitonin secreting neuroendocrine tumors

Popovic Bojana , Macut Djuro , Elezovic Kovacevic Valentina , Isailovic Tatjana , Bozic Antic Ivana , Bogavac Tamara , Ilic Dusan , Ognjanovic Sanja , Rodic Gordana , Petakov Milan , Damjanovic Svetozar

Introduction: Calcitonin secreting neuroendocrine tumors (NET) are rare and not well recognized. Due to many similarities, it is sometimes difficult to differentiate them from medullary thyroid carcinoma (MTC), which can hamper choice of proper therapy. We investigated our group of patients with this type of NET in terms of diagnosis and biology.Patients and Methods: We analyzed 38 patients with calcitonin secreting NET (5% of all our patients with NET)....

ea0049ep1114 | Female Reproduction | ECE2017

Novel insulin resistance index using C-peptide is reliable predictor of insulin resistance in women with PCOS

Bozic-Antic Ivana , Ilic Dusan , Bjekic-Macut Jelica , Vojnovic-Milutinovic Danijela , Ognjanovic Sanja , Bogavac Tamara , Popovic Bojana , Isailovic Tatjana , Elezovic Valentina , Stanojlovic Olivera , Macut Djuro

Introduction: Recently, it was suggested that insulin resistance index using C-peptide (CIR) could be a better marker of insulin resistance than homeostasis model assessment (HOMA-IR) in patients with type 2 diabetes mellitus. The aim of this study was to investigate performance of CIR index in PCOS subjects.Methods: We evaluated 187 PCOS women (PCOS: 25.38±6.32 kg/m2; 26.01±5.16 years) diagnosed using ESHRE/ASRM criteria and 42 heal...