Searchable abstracts of presentations at key conferences in endocrinology

ea0064026 | An adrenal tumor with gynecomastia | BES2019

An adrenal tumor with gynecomastia

De Herdt C , Philipse E , De Block C

Initial presentation and work-up: A 42-year-old man was referred to the endocrinologist because of an incidentaloma of the right adrenal with a maximum diameter of 4.2 cm on echography of the abdomen. Echography was performed because the patient presented with icterus. An abdominal CT scan confirmed a right adrenal mass with a maximum diameter of 5.1 cm. The intensity of the adrenal adenoma amounted 39 Hounsfield units. The patient did not have a significant medical history, e...

ea0048cp15 | Poster Presentations | SFEEU2017

Pituitary apoplexy presenting with hypopituitarism and a generalised tonic clonic seizure

Gandhi S E , Kueh C J L , Perry C

Case history: A 28 year old male presented following his first generalised tonic clonic seizure in the context of a headache with mild photophobia, nausea and vomiting. He was haemodynamically stable, euvolaemic and had no focal neurological deficit, but was mildly disoriented. He had reported cannabis and MDMA use 8 days prior to his presentation. The patient was profoundly hyponatraemic with a serum sodium of 108.Investigations: Serum osmolality was 22...

ea0040p17 | (1) | ESEBEC2016

Aggressive multifocal angiomyxoma – a surgical challenge

Lambrescu I , Blaga C , Stefan C , Soare I , Fica S

Introduction: Aggressive angiomyxoma is a rare, benigne, misdiagnosed tumor that occurs preferentially in women during the reproductive age.Case report: We present a 43-year-old Caucasin woman diagnosed with aggressive multifocal angomyxoma developing for the last 8 years. The patient underwent five surgical procedures during this period of time in order to debulk the pelvis and subperitoneal space of a large invasive tumor. The last surgical approach re...

ea0035p582 | Endocrine tumours and neoplasia | ECE2014

Eleven base pair (AACACTCTAGC) deletion of SDHB Ex-4 from c.325 to c.335 in the patient with malignant Vaginal Paraganglioma – A case report

Gupta Poonam , Khurana Madan Lal , Ammini A C , Bal C S

Background: Pheochromocytoma (PHEO) and paraganglioma (PGL) are the tumors of adrenal medulla and extra adrenal ganglia respectively. Most of these PHEO/PGL are benign and may become malignant, if remain undiagnosed/untreated for a longer time. Vaginal PGL are extremely rare. There is not much published literature on vaginal PGL.Objective: To carry out biochemical and genetic analysis of the patient with MIBG negative malignant vaginal PGL.<p class="...

ea0029p221 | Calcium &amp; Vitamin D metabolism | ICEECE2012

Perioperative management difficulties in parathyroidectomy for primary vs secondary and tertiary hyperparathyroidism

Corneci C. , Stanescu B. , Trifanescu R. , Neacsu E. , Poiana C.

Background: In patients with hyperparathyroidism, parathyroidectomy is the only curative therapy. Anesthetic management differs function of etiology (primary vs secondary or tertiary hyperparathyroidism) and surgical technique (minimally invasive or classic parathyroidectomy).Aim: To evaluate peri-operative management in parathyroidectomy for hyperparathyroidism of various etiologies, in a tertiary center.Patients and methods: Two ...

ea0029p693 | Diabetes | ICEECE2012

Variations in insulin daily dose and weight with continuous subcutaneous insulin infusion therapy

Belo S. , Esteves C. , Pereira M. , Neves C. , Carvalho D.

Introduction: Intensive diabetes type 1 management can be achieved either with multiple daily insulin injection therapy or with continuous subcutaneous insulin infusion (CSII). The former is becoming increasingly popular do to its positive effects on glycemic control.Objectives: Evaluate the evolution of total daily insulin dose (TDID) and weight on patients with CSII.Methods: Patients with CSII of our department were included. Dat...

ea0029p868 | Endocrine tumours and neoplasia | ICEECE2012

Medullary thyroid carcinoma with liver metastasis presenting as watery diarrhea for 1 year

Lam I. , Chaing H. , Wang C. , Chang C.

A 66-year-old woman had no history of systemic diseases. She had developed watery diarrhea for 4 months initially, without abdominal pain, fever, any aggravating or relieving factor. She visited gastroenterologist, and colonoscopy showed only mixed hemorrhoid. Irritable bowel syndrome was impressed then. Thus, anti-spasmodics and anti-diarrheals were prescribed. However, diarrhea persisted for 1 year, and body weight loss of 7 kg occurred during this period of time. She later ...

ea0029p1004 | Growth hormone IGF axis - basic | ICEECE2012

Thyroid function during long-term GH treatment in children affected by idiopathic GH deficiency

Ciresi A. , Guarnotta V. , Perrone C. , Galluzzo A. , Giordano C.

Alterations in the thyroid axis have been reported following GH therapy both in adults and children with GH deficiency (GHD), even if the clinical significance of these changes, in small and short-term studies, remains uncertain. To evaluate the impact of GH replacement on thyroid status in a large selected cohort of prepubertal children with idiopathic GHD during a 3-years follow-up. Study outcome considered FT3, FT4 and TSH modifications (delta) during therapy and their corr...

ea0029p1016 | Male Reproduction | ICEECE2012

Mutation analysis of NR5A1 gene encoding steroidogenic factor 1 in cryptorchidism and male infertility

Ferlin A. , Vinanzi C. , Zuccarello D. , Ghezzi M. , Foresta C.

The gene NR5A1, which encodes steroidogenic factor 1 (SF-1), is a pivotal transcriptional regulator of genes involved in adrenal and gonadal function, including several steroidogenic enzymes and key genes necessary for male sex determination and differentiation, testicular descent and reproduction (such as SOX9, AMH, INSL3, and AR). The most severe phenotypes associated with NR5A1 mutations include gonadal dysgenesis, disorders of sex development (DSD) and adrenal insuf...

ea0029p1296 | Paediatric endocrinology | ICEECE2012

Evaluation of circulating kisspeptin as a biomarker for differential diagnostic of central precocious puberty

Caragheorgheopol A. , Padure A. , Dumitrescu C. , Procopiuc C. , Gherlan I.

Introduction: Kisspeptins and their cognate receptor GPR-54 (Kiss-1) were found to be regulators of the hypothalamo-pituitary–gonadal axis. It is under debate if the onset of central precocious puberty (CPP) could be triggered by early increase of kisspeptin. We aimed to assess serum kisspeptin levels in girls in order to evaluate its potential as a reliable biochemical marker for differential diagnosis of CPP.Materials and methods: The girls enroll...