Endocrine Abstracts

TSH activates the TSH receptor (TSHR) thereby stimulating the function of thyroid follicular cells (thyrocytes) leading to biosynthesis and secretion of thyroid hormones. Because TSHR is involved in several thyroid pathologies there is a strong rationale for the design of small molecule ‘drug-like’ ligands (SMLs).rhTSH (ThyrogenR) has been used in the follow-up of patients with thyroid cancer to increase the sensitivity for detection...

Introduction: Polycystic ovary syndrome (PCOS) have an increased rate of metabolic syndrome (MS). Many studies have proved that adiponectin is closely associated with MS and participate in the disturbances of gonadal axis. The aim of the study was to evaluate the association of adiponectin levels with MS in PCOS.Patients and methods: Study group included 38 patients with PCOS (Rotterdam criteria) compared to 30 healthy volunteers age and sex matched, all...

Introduction: The association of type 1 diabetes mellitus (DM1) with thyroid diseases is well known, especially in the field of polyglandular autoimmune diseases. Thyroid status can influence the necessary of insulin – decreased in hypothyroidism and higher in hyperthyroidism. We wanted to evaluate the prevalence of thyroid pathology in patient with DM1.Patients and methods: Cross-sectional study including 66 patients with DM1 (23 men, 43 women) age...

Introduction: Wolfram syndrome, a very rare condition, is a neurodegenerative disorder characterized by diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) which appear in childhood, hampering diagnosis and treatment. Others less frequent features as hypergonadotropic hypogonadism, microvascular disease and local fibromatosis are reported in a male patient diagnosed at the age of 18 years.Case report: An 18-year-old male patient d...

Background: Congenital adrenal hyperplasia, (CAH) is a common autosomal recessive condition, 95% of which is attributable to mutations in the 21-hydroxylase (CYP21) gene. There is a wide range of clinical features and genotype phenotype correlations for common mutations are well described.Case: EG presented to the endocrine clinic at the age of 3.5 years with pubarche of 6 months duration and Tanner staging of PH3, B1and clitoromegaly (Prader stage 1) Ur...

Insulin oedema is uncommon and poorly understood. It has been reported mainly in the adult literature. We present one of the youngest cases reported in the literature.A previously obese 9-year-old boy gradually lost weight over 18-month period and experienced polyuria and polydipsia for several months. He presented in diabetic ketoacidosis (blood glucose 24 mmol/l, pH 7.13, bicarbonate 6.6 mmol/l, potassium 3.13 mmol/l, urinary ketones 3+) which resp...

A 64-year-old woman who had been on Lithium 600 mg/day for 6 years for affective neurosis, presented in 2005 with acute confusion associated with a serum calcium concentration of 3.02 mmol/ which improved with rehydration. She was followed-up in outpatients and diagnosed with ‘Lithium-associated hypercalcaemia’ likely to be secondary to parathyroid hyperplasia. Results showed a corrected calcium of 2.74 mmol/l (2.1–2.55), phosphate 1.00 mmol/l (0.74–1.52), ...

Clinical features associated with PCOS include obesity, hirsutism or acne, cycle abnormalities and infertility. Therefore, depending on the primary complaint these patients visit different medical specialists such as general practitioner, pediatrician, dermatologist, medical endocrinologist and gynecologist. The variability in primary complaint asks for different approaches in the work-up of these patients. Hence, doctors usually see just a proportion of the overall spectrum o...

The clinical diagnostic examination of patients and the research-oriented investigation of the pathophysiology of skeletal disorders require imaging techniques that allow to visualize the skeleton at different scales: from the organ level to tissue, cellular, and subcellular levels, depicting morphology and function. Progress in the field of imaging technologies resulted in methods suited for clinical investigation of patients in vivo, non-invasive methods for preclinical anim...

Objective: Assessment of the accuracy of physical examination performed by thyroid surgery team doctors at thyroid clinic.Method: Random review of 120 new referrals to thyroid clinic, with review of clinical findings on physical examination on first attendance to clinic and compare the clinical findings with subsequent ultrasound scan findings.Results: Of total number of 120 patients, 63 had solitary nodule on physical examination,...