Endocrine Abstracts

Introduction: The prevalence of obesity in children and adolescents has dramatically increased over the last 20–30 years.Childhood overweight is associated with higher risk of obesity into adulthood and a higher incidence of metabolic consequences.Objectives: To identify the prevalence of metabolic complications in obese children and adolescents.Methods: One thirty-two obese children and adolescents (age...

Clinical caseIntroduction: Insulinoma is a rare disorder with an estimated incidence of 1 case per 250 000 people per year.Case report: 37 years old female, with a history of irritable bowel syndrome, dyslipidemia and kidney stones. In December 2010, she developed a headache, dizziness and visual disturbances, predominantly in the evening and amnesia for some of the episodes. Initially interpreted as peripheral vertiginous syndrome, because of recurrence...

Objective: To investigate the impact of dietary intervention of advanced glycation end products (AGEs) intake on hormonal and metabolic profile in women with polycystic ovary syndrome (PCOS).Methods: After baseline evaluation, 23 women with PCOS (mean±S.D., age: 23.4±5.7 years; body mass index (BMI): 26±5.7 kg/m2) underwent the following consecutive 2-month dietary regimens: a hypocaloric diet with ad-libitum</...

Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting 5–10% of reproductive -age female population.The aim of this study was to determine the clinical features, metabolic and hormonal profile in obese and overweight women with PCOS.Patients and method: A total of 102 women (age 31.28±6.05 and BMI 33.02±5.93) with PCOS and 110 (age 32.35±4.96 and BMI 33.05±5.87) matched controls were invest...

Data about the entire sperm DNA methylome are limited to two sperm donors whereas studies dealing with a greater number of subjects focused only on a few genes or were based on low resolution arrays. This implies that information about what we can consider as a normal sperm DNA methylome and whether it is stable among different normozoospermic individuals is still missing. The definition of the DNA methylation profile of normozoospermic men, the entity of inter-individual vari...

Introduction: Most paediatric medicines have not undergone extensive clinical trials in children and as a necessity are frequently prescribed off-label, a practice which is recognised to be associated with an increased risk of adverse drug reactions (ADRs).Aims: To assess the use of routinely acquired healthcare data to identify medication utilisation and specifically drug discontinuation, as a signal for possible ADR occurrence in children: using orlist...

Introduction: The risk for the development of germ cell tumors is hard to predict in patients with disorders of sex development (DSD) and their optimal management has been a continuous matter of debate. The risk varies between unknown and 40–60% in Denys-Drash/Frasier syndrome. This malignant potential opposes itself firmly to the recent interest in a more conservative approach regarding gonadectomy.Case presentation: We present the case of a 20-yea...

Prader-Willi is a complex genetic syndrome with characteristic phenotype, obesity, hyperphagia, and endocrine hypothalamic dysfunctions. We present particular features of a case with confirmed Prader Willi syndrome (PWS).Case report: EP, only child of a young non-consanguine couple, was born in 1994 at 34 weeks of amenorrhoea, with a low Apgar score (7) and a weight of 2200 g. She presented important hypotonia in the first 6 weeks of life, needing gavage...

Hormonal treatment (HT) represents the only complete therapy of the consequences of the postmenopausal estrogenic deficiency. Quality of life in postmenopausal women is often compromised. We evaluated the quality of life (appreciated with IQL questionnaire) in 80 postmenopausal women – 40 with intact uterus, treated with natural estrogens associated with progestin, and 40 non-treated women. Group selection (treated/not treated) was made function of the inform consent of t...

Introduction: Undernutrition is common in haemodialysed diabetic patients. To estimate the nutritional status before and after dialysis, we followed up prospectively initially undialysed uremic diabetic patients.Methods: All 20 patients had initial body composition (Lean Body Mass, LBM, using DEXA) and serum albumin (SA) measurements. Ten patients underwent hemodialysis (HD) after 15 m (mean). They had a similar LBM & SA evaluation 6.5 m after starti...