Searchable abstracts of presentations at key conferences in endocrinology

ea0011p776 | Thyroid | ECE2006

Safety and efficacy of administering 0.2 mg of recombinant human TSH for two consecutive days as an adjuvant to low-dose radioiodine therapy in out-patients with large non-toxic multinodular goitre

Giusti M , Cappi C , Santaniello B , Ceresola E , Augeri C , Lagasio C , Minuto F

Recombinant human TSH (rhTSH) has recently been used as an adjuvant to the treatment of non-toxic multinodular goitre (MNG) by means of 131I. The aim of our study was to evaluate the efficacy of 0.2 mg rhTSH or placebo administered im on 2 consecutive days before a fixed therapeutic dose of 14 mCi of 131I. Thirteen elderly patients (71±7 years) with large non-toxic MNG (group 1) were treated with rhTSH plus 131I. While a control group of 8...

ea0011p912 | Thyroid | ECE2006

Is 131I therapy for hyperthyroidism harmful for testis function?

Ceccarelli C , Canale D , Fiore E , Moschini C , Caglieresi C , Vitti P , Pinchera A

Radioiodine-131 is commonly used for treatment of hyperthyroidism, however the effects on testis function are not known. This prompted us to study testis function in hyperthyroid men after 131I treatment. 15 hyperthyroid patients scheduled for 131I treatment underwent: testis US, hormone assessment and sperm analysis before and 45 days, 3, 6 and 10–15 months after 131I. The control group (for testis volume and semen analysis) was constitut...

ea0009p56 | Growth and development | BES2005

Obese subjects have lower satiety

Giles C , le Roux C , Aylwin S , Hunt C , Ghatei M , Frost G , Bloom S

Background: Obese subjects are usually in a positive energy balance despite their best efforts to lose weight. This study aimed to determine if hunger, nausea and satiety levels differ in lean and obese subjects after consuming varying calorific meals.Method: Following an overnight fast, test meals of 250, 500, 1000, 2000 and 3000 kcal were consumed by 19 lean and 19 obese subjects. Hunger, nausea and satiety levels were measured using visual analogue sc...

ea0007p169 | Neuroendocrinology and behaviour | BES2004

The role of the melanocortin 5 receptor in the hypothalamic regulation of appetite and pituitary function

Sajedi A , Abbott C , Small C , Haskell-Luevano C , Ghatei M , Bloom S

The melanocortin receptors (MCR), MC3R and MC4R, have established roles in feeding and pituitary function. MC5R mRNA expression has been identified at low levels in the hypothalamus. However, a role for this receptor in appetite and pituitary function remains to be elucidated. We investigated the effects of central administration of an MC5R agonist (3,3,3-triphenylpropionyl-His-D-Phe-Arg-Trp-NH2) on food intake and plasma pituitary hormone levels. We did not observe...

ea0083ercp1 | Endocrine-related Cancer | EYES2022

Synchronous eutopic and ectopic papillary thyroid carcinoma

M. L. Guia Lopes , C Saraiva , C Antunes , E Silva , C Limbert , M Chorao , L Viana Fernandes , J Sequeira Duarte

Background: Papillary thyroid carcinomas are the most common thyroid malignancies. They are more prevalent in women and have a bimodal age distribution. Thyroglossal duct cyst carcinomas are extremely rare (occurring in only 1% of all thyroglossal duct cysts). The large majority of these carcinomas are of thyroid origin.Case presentation: A 25-year-old woman with no significant medical history was referred to the Endocrinologist with 1-month complaints o...

ea0067gp25 | Poster Presentations | EYES2019

Atypical presentation of an acromegalic patient

Verdeş Andreea Maria , Căpăţ C , Poiană Cătălina

Background: Acromegaly is a rare disorder, with a prevalence of 6 cases of 100000 and an annual incidence of 3–4 new cases of one million. It is almost always the consequence of GH secreting pituitary adenomas and, rarely, caused by nontumoral somatotrophic hyperplasia.Case presentation: 54 years old patient, heavy smoker, hypertensive, dyslipidemic, obese, presents in June 2019 with unspecific symptoms: physical asthenia, hypersomnia (falls asleep ...

ea0029p99 | Adrenal cortex | ICEECE2012

Cushing’s disease – limitations and boundaries

Idriceanu J. , Preda C. , Galesanu C. , Ungureanu M. , Scripcariu V. , Vasiliu I. , Potorac I. , Popovici R. , Mogos V. , Vulpoi C.

Introduction: Cushing’s disease is the most frequent cause of hypercortisolism. Although the classical form is easy to diagnose, nonspecific features raise differential diagnosis problems. Severe forms are associated with high mortality, but subclinical hypercortisolism also has significant morbidity.Patients and methods: Retrospective study of Cushing’s disease evolution in 14 patients, diagnosed between 2000 and 2011 (11 women, 3 men, age at ...

ea0029p396 | Clinical case reports - Pituitary/Adrenal | ICEECE2012

Central diabetes insipidus: about two clinical cases

Nogueira C. , Matos M. , Esteves C. , Jorge G. , Couto J. , Neves C. , Queiros J. , Vinha E. , Bernardes I. , Carvalho D.

Introduction: Central diabetes insipidus (CDI) is produced by the destruction of the magnocellular neurons of the hypothalamic supraoptic and paraventricular nuclei which results in decreased arginine vasopressin (AVP) synthesis and secretion.Case report 1: Forty-five year old female, previously healthy, was observed in April 2011 complaining of polydipsia, polyuria, nocturia and weight loss since January. Diabetes mellitus (DM) was excluded and she was ...

ea0029p852 | Endocrine tumours and neoplasia | ICEECE2012

Effect of dopamine agonists on the tumor size of prolactinomas: are suppressive doses different from those that normalize prolactin serum levels?

Sardella C. , Urbani C. , Lombardi M. , Manetti L. , Cosci C. , Brogioni S. , Marchello A. , Martino E. , Bogazzi F.

Prolactin-secreting (PRL) adenomas are about 40% of all pituitary adenomas. The most important clinical symptoms of PRL excess are gonadal and sexual dysfunction as a result of tumor expansion in patients with macroadenomas. Medical therapy of prolactinomas relies on the use of dopamine agonists which induce normalization of PRL levels and shrinkage of the tumor mass in the majority of patients. The present study evaluated whether doses of dopamine agonist inducing normalizati...

ea0029p944 | Female Reproduction | ICEECE2012

Neonates of women with polycystic ovary syndrome display increased oxidative stress markers and metabolic aberrations comparable to gestational diabetes offspring

Boutzios G. , Livadas S. , Piperi C. , Vitoratos N. , Adamopoulos C. , Hassiakos D. , Iavazzo C. , Diamanti-Kandarakis E.

Context: Polycystic ovary syndrome (PCOS) and gestational diabetes (GDM) are two common metabolic disorders. The serum oxidative stress markers advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) have been found to be elevated in women with PCOS and GDM compared to controls. However the impact of these harmful molecules to their offspring is under investigation.Objective: To evaluate AGEs and AOPPs serum levels along wi...