Searchable abstracts of presentations at key conferences in endocrinology

ea0029s67.1 | Central regulation of energy homeostasis | ICEECE2012

CNS control of energy and glucose metabolism

Konner C.

The tight coordinated regulation of food intake and energy expenditure represents the prerequisite for stable body weight control. Dysregulation of energy homeostasis, i.e. obesity represents a major and steadily growing health burden to western societies. The CN coordinates both the control of energy homeostasis, i.e. the balance of food intake and energy expenditure as well as peripheral fuel metabolism. Anatomical lesion experiments, pharmacological inhibition of signaling ...

ea0029p675 | Diabetes | ICEECE2012

Not all neuropathies in people with diabetes are due to diabetic neuropathy - a case of chronic inflammatory demyelinating polyneuropathy(CIDP) in a type 1 diabetic

Eboh C.

46yr old gentleman. Recently diagnosed with late-onset type 1 diabetes.HBA1C of 12% (108 mmol/molHb) at diagnosis. Also Vit B12 deficient. Normal TSH, Normal 9am cortisol, Normal TTG antibodies. On Novomix 30 Insulin.No diabetic end-organ complication. Smokes 8g tobacco/day. Moderate alcohol intakePresented with a year history of painful neuropathy,started with his left toes and progressed in an ascending manner to involve the whol...

ea0021s6.1 | Fit or fat? Mechanisms regulating our metabolic fate | SFEBES2009

FTO variants are associated with overeating and many long-term health problems associated with obesity

Palmer C

Monogenic obesity disorders and mouse models of obesity have overwhelmingly pointed to hyperphagia as the predominant genetic force in promoting obesity, it was therefore no surprise when the most robust common variant associated with obesity from GWAS studies was associated with increased energy intake. We and other groups have shown that variants in the FTO gene are not associated with increased food intake per se, but rather display a preference for energy dense foods resul...

ea0017s2 | (1) | BSPED2008

Antenatal screening for congenital adrenal hyperplasia: clinical practice or research?

Brain C

The impact of having a baby delivered with ambiguous genitalia should not be underestimated. In the UK congenital adrenal hyperplasia (CAH) secondary to 21-hydroxylase deficiency is the commonest cause of genital virilization of a genetic female. Affected females may require feminizing surgery in the first year of life, with further surgery often being necessary at the time of puberty. Advances in molecular genotyping in CAH have made early antenatal diagnosis possible and the...

ea0017s6 | (1) | BSPED2008

Long-term quality of life after cancer therapy in childhood

Eiser C

Survival rates following childhood cancer have improved, but the prevalence of late-effects and possible length of life remaining, mean that questions have been raised about the quality of life (QOL) of survivors. Results from a wide range of studies suggest that QOL among survivors is generally as good, or sometimes better than that reported by the normal population, or healthy siblings. However, considerable variation has been noted, depending on type of cancer and treatment...

ea0015s35 | Evolving endocrine targets for C-type natriuretic peptide (CNP) | SFEBES2008

Novel cardiovascular roles for CNP

Villar C

C-type natriuretic peptide (CNP) represents a key paracrine member of the natriuretic peptide family that play an important role in the regulation of vascular tone and local blood flow. CNP is found abundantly in vascular endothelial cells and it is now clear that CNP can be released from the endothelium to act on adjacent cells, both in the vessel wall and the circulation. Thus, it has been shown that CNP hyperpolarises and dilates vascular smooth muscle in the mammalian resi...

ea0012s4 | Society for Endocrinology European Medal Lecture | SFE2006

Assessment of growth hormone levels: Tailor-made assays for specific clinical questions

Strasburger C

Since more than 40 years growth hormone (GH) measurement has been possible by immunoassay techniques. Although these methods have greatly augmented the diagnostic tools of endocrinologists following patients with GH-related disorders, their use has also brought about confusion and left uncertainties.Cut-off levels for dynamic GH tests in the diagnosis of both GH deficiency and acromegaly have to be considered arbitrary, since different commercial hGH ass...

ea0011s33 | Flies, worms and fish: use in endocrine research | ECE2006

Specifying the cellular responses to IGF signalling by IGF binding proteins: new lessons from the zebrafish model

Duan C

The insulin-like growth factor (IGF) signalling pathway plays a fundamental role in regulating growth and development. In extracellular environments, IGFs are present in complexes with high-affinity binding proteins (IGFBPs). Studies using cultured mammalian cell lines and transgenic mice suggest that IGFBPs have the ability to inhibit and/or potentiate IGF actions. Some IGFBPs may even possess intrinsic biological activities that are IGF-independent. The in vivo physio...