Searchable abstracts of presentations at key conferences in endocrinology

ea0029p852 | Endocrine tumours and neoplasia | ICEECE2012

Effect of dopamine agonists on the tumor size of prolactinomas: are suppressive doses different from those that normalize prolactin serum levels?

Sardella C. , Urbani C. , Lombardi M. , Manetti L. , Cosci C. , Brogioni S. , Marchello A. , Martino E. , Bogazzi F.

Prolactin-secreting (PRL) adenomas are about 40% of all pituitary adenomas. The most important clinical symptoms of PRL excess are gonadal and sexual dysfunction as a result of tumor expansion in patients with macroadenomas. Medical therapy of prolactinomas relies on the use of dopamine agonists which induce normalization of PRL levels and shrinkage of the tumor mass in the majority of patients. The present study evaluated whether doses of dopamine agonist inducing normalizati...

ea0029p944 | Female Reproduction | ICEECE2012

Neonates of women with polycystic ovary syndrome display increased oxidative stress markers and metabolic aberrations comparable to gestational diabetes offspring

Boutzios G. , Livadas S. , Piperi C. , Vitoratos N. , Adamopoulos C. , Hassiakos D. , Iavazzo C. , Diamanti-Kandarakis E.

Context: Polycystic ovary syndrome (PCOS) and gestational diabetes (GDM) are two common metabolic disorders. The serum oxidative stress markers advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) have been found to be elevated in women with PCOS and GDM compared to controls. However the impact of these harmful molecules to their offspring is under investigation.Objective: To evaluate AGEs and AOPPs serum levels along wi...

ea0029p1472 | Pituitary Clinical | ICEECE2012

Acromegaly, does tumor size matters?

Serra F , Duarte S , Ferreira R , Moniz C , Simoes H , Marques C , Azinheira J , Saraiva C , Saraiva M

Introduction: Acromegaly is a rare disease which results from a GH producing adenoma. Around 70–80% are macroadenomas. The therapeutic options currently available are surgery, radiotherapy (RT) and medical treatment (MT). According to literature microadenomas have a higher remission rate, around 80%.Methods: A retrospective chart review of the patients with acromegaly treated in our centre from 1976 to 2011 was performed. In terms of disease control...

ea0029p1707 | Thyroid (non-cancer) | ICEECE2012

Laminin and poly-laminin, a polymeric form of laminin assembled at acidic pH, differentially modulate PCCL3 thyroid cell behavior

Palmero C. , Barroso M. , Souza E. , Merlmestein C. , Takiya C. , Carvalho D. , Miranda-Alves L. , Nasciutti L.

The extracellular matrix protein laminin forms polymers both in vivo and in vitro. Acidification of pH leads to the formation of an artificial polymer with biomimetical properties, named poly-laminin (polyLM). Follicular cells in the thyroid are in close contact with laminin, but their response to this important extracellular signal is still poorly understood. Thyroid PCCL3 epithelial cells cultivated either on glass, regular laminin (LM) or laminin previously po...

ea0026oc1.6 | Thyroid/Adrenal | ECE2011

Increased risk of infections in patients with Addison's disease

Smans L C C J , Souverein P C , Leufkens H G M , Hoepelman I M , Zelissen P M

Context: Previous studies have suggested that infections are an important cause of death in patients with Addison’s disease, but epidemiological studies on the frequency of infections in this population are scarce.Design and setting: We conducted a cohort study, using data from the Dutch PHARMO record linkage system, linking patients’ demographics and medical histories to the use of prescription drugs, diagnostic and therapeutic data from hospi...

ea0026p486 | Thyroid cancer | ECE2011

mTOR inhibition hampers cell viability in selected human medullary thyroid carcinoma primary cultures

Filieri C , Zatelli M C , Minoia M , Tagliati F , Buratto M , Ambrosio M R , Pelizzo M , degli Uberti E C

It has been demonstrated that everolimus, an mTOR inhibitor, has potent anti-proliferative effect in a human Medullary Thyroid Carcinoma (MTC) cell line, TT, and in two human MTC primary cultures. We aimed at evaluating the possible antiproliferative effects of everolimus in a group of 20 human MTC in primary culture. To this purpose, 20 MTCs were dispersed in primary cultures, treated without or with 1 nM – 1 μM everolimus, 10 nM SOM230, and/or 50 nM IGF1. Cell viab...

ea0007p42 | Diabetes, metabolism and cardiovascular | BES2004

PYY deficiency may reinforce obesity

Le Roux C , Aylwin S , Batterham R , Borg C , Wynne K , Hunt C , Coyle F , Ghatei M , Patel A , Bloom S

Background: The gut hormone PYY3-36 (PYY) is released into the circulation after eating and physiologically inhibits food intake. Obese and lean subjects are equally sensitive to this effect, however fasting levels of PYY are reduced in obese subjects.Methods: We investigated the postprandial PYY response and satiety response using a visual analogue scale (VAS) to 6 test meals of increasing calorie content in 20 lean and 20 obese subjects. We also infuse...

ea0007p95 | Endocrine tumours and neoplasia | BES2004

The effects of surgery and tamoxifen on serum IGF-I and IGFBP3 levels in breast cancer

McVittie C , McCarthy K , Laban C , Miraki-Moud F , Camacho-Hubner C , Bustin S , Carpenter R , Jenkins P

Background: Serum IGF-I and IGFBP-3 levels respectively have a positive and negative association with subsequent risk of breast cancer. The anti-oestrogen tamoxifen is widely used as adjunctive therapy after resection of primary breast tumours. Tamoxifen has been reported to influence serum IGF-I, although its effects on BP-3 are unknown. The effects of tumour resection itself on IGF-I and BP-3 levels are unclear.Aims: To determine the effects of surgery...

ea0078p17 | Diabetes | BSPED2021

Do hospital admissions improve outcomes for children and young people with poor diabetes control?

Jacques John E , Ferguson Elspeth C

Introduction: Achieving an HbA1c of less than 48 mmol/mol minimises the risk of complications in children and young people with type one diabetes. Elective admissions to hospital are one option employed to improve glycaemic control in patients with an HbA1c above target. There is however limited evidence to support such admissions. We aimed to retrospectively compare glycaemic control between patients electively admitted to hospital to stabilise their dia...

ea0051oc5.9 | Oral Communications 5 | BSPED2017

Adult height in patients with testotoxicosis

Lane Laura C , Flowers Josephine , Cheetham Timothy

Background: Familial male-limited precocious puberty (FMPP) or ‘testotoxicosis’ is a rare form of gonadotrophin-independent precocious puberty. There is a paucity of data on final adult height in these patients and no consensus on what constitutes appropriate treatment. Our aim was to assess the management and final height of patients with FMPP under our care as well as those reported in the literature.Methods: Growth data were obtained from no...