Searchable abstracts of presentations at key conferences in endocrinology

ea0029p699 | Diabetes | ICEECE2012

Evolution of macro-angiopathy 5-years after islet transplantation (IT) in type 1 diabetes

Vantyghem M. , Balavoine A. , Defrance F. , Douillard C. , Van Belle E. , Foucher C. , Gautier C. , Kerr-conte J. , Noel C. , Pattou F.

Long-term benefit-risk ratio of IT remains poorly evaluated. The aim of this work was to determine the evolution of macroangiopathic complications 5 years after IT.21 out of the 36 prospectively followed islet-transplanted patients in a single center, had at least 5 years of follow-up and were included. Their initial features were: duration of C-peptide negative diabetes: 28±9years; age: 43±7years; BMI: 24±0.2 kg/m2; 8/21 kidney-transplant...

ea0029p776 | Endocrine tumours and neoplasia | ICEECE2012

Metformin inhibits the androgen mediated up-regulation of Insulin Growth Factor-I Receptor in prostate cancer cells

Malaguarnera R. , Sacco A. , Voci C. , Belfiore A.

Introduction: The insulin-like growth factor-I receptor (IGF-IR) plays a key role in regulating growth, survival and invasion of several human malignancies including prostate cancer. In prostate cancer cells, the IGF-IR expression is upregulated by androgens through a nongenotropic signaling unresponsive to antiandrogens and requiring AMP-response element-binding protein (CREB) activation. This mechanism sensitizes cells to the proliferative and protumor effects of IGF-I. Metf...

ea0029p784 | Endocrine tumours and neoplasia | ICEECE2012

TNFα induced aromatase expression is mediated by the Early Growth Response transcription factors in breast adipose

To S. , Simpson E. , Knower K. , Clyne C.

Breast cancer remains the leading cause of cancer-related death in Australian women. Up to 70% of post-menopausal tumours are estrogen-receptor positive (ER+), dependent on estrogen for continued growth and proliferative advantage. Adjuvant anti-estrogen therapies are considered the cornerstone approach to the treatment of such tumours, and research is ongoing to maximize its effectiveness. The major source of estrogens for ER+ breast cancers is local conversion of androgen pr...

ea0029p812 | Endocrine tumours and neoplasia | ICEECE2012

Is biochemical screening for pheochromocytoma in adrenal incidentalomas expressing low unenhanced attenuation on computed tomography necessary?

Sane T. , Schalin-Jantti C. , Raade M.

Introduction: Pheochromocytomas are characterized by a high attenuation value on unenhanced computed tomography (CT). It is not known whether pheochromocytoma can be outruled as a cause of adrenal incidentalomas based on unenhanced attenuation values only. We evaluated the outcome of routine biochemical screening for pheochromocytoma in a series of patients with adrenal incidentalomas in relationship to the unenhanced attenuation values on CT.Design and ...

ea0029p897 | Female Reproduction | ICEECE2012

Progesterone levels on the hCG day and outcomes IVF in women with polycystic ovary syndrome

Peng C. , Long X. , Lu G.

Background: The purpose of this study was to determine the incidence of premature luteinization in patients with polycystic ovary syndrome and compared the main determinants of success in IVF in PCOS patients with and without premature luteinization.Methods: Retrospective analysis of 180 PCOS women of Chinese Han origin with infertility who underwent controlled ovarian hyperstimulation (COH) with an exogenous gonadotropin/GnRH antagonist protocol. Hormon...

ea0029p1043 | Male Reproduction | ICEECE2012

Maternal malnutrition alters the leptin expression in the rats epididymis

Gombar F. , Sampaio F. , Ramos C.

Several papers show that maternal malnutrition can affect the reproductive capability of the offspring. Leptin is an important regulator of the reproductive system, however little is known about its role in the epididymis. The goal of this study was to evaluate whether the maternal malnutrition during lactation can alter the expression of leptin and its receptors in the epididymis of rats. Six rat dams were randomly assigned to the control group (C), with free access to a stan...

ea0029p1177 | Obesity | ICEECE2012

Weight-perception in male career US firefighters and its association with cardiovascular risk factors

Baur D. , Christophi C. , Kales S.

Objective: To evaluate the associations among body mass index, weight perception and cardiovascular risk factors in male career US firefighters.Design: The present cross-sectional study was nested within a federally-funded multicenter, prospective cohort investigation of cardio-respiratory fitness (CRF), health and employment outcomes among career firefighters.Subjects: Seven hundred and sixty-eight male career firefighters from tw...

ea0029p1185 | Obesity | ICEECE2012

Efficacy of orlistat vs placebo in the improvement of lipid profile among overweight and obese patients: a meta-analysis

Malong C. , Delgado J. , Cunanan E.

Background: According to the 6th National Nutrition Health Survey, the Filipino is generally unfit, with increasing incidences of major risk factors for cardiovascular disease like hypertension, abnormal lipid profile, obesity and diabetes over the last 5 years. Orlistat, a lipase inhibitor is one of the medications used to facilitate weight loss in obese patients. Given that weight loss is known to be associated with an improvement in the serum lipid profile, concurrent impro...

ea0029p1384 | Pituitary Clinical | ICEECE2012

Prevalence and incidence of pituitary adenomas; a population based study in Malta

Gruppetta M. , Mercieca C. , Vassallo J.

Context: Epidemiological data is important to correctly quantify the extent of disease and needed health care resources. There are no reports on both incidence and prevalence rates for pituitary adenomas (PAs) together in the same population.Objective: The objective of the study was to establish the prevalence and incidence of pituitary adenomas with in-depth analysis of their various subtypes in a well defined population.Design: T...

ea0029p1392 | Pituitary Clinical | ICEECE2012

Permanent panhypopituitarism is a rare complication of acute bacterial sinusitis

Lavan A. , Hannon M. , O'Brien M. , Thompson C.

Permanent pan-anterior hypopituitarism is a rare complication of bacterial sinusitis, with only six cases reported worldwide. However, all were reported before the advent of MR imaging and most did not have what is now regarded as gold standard evaluation of pituitary function. Also, all previous cases noted an interval of months between resolution of sinusitis and development of hypopituitarism. We report two cases of previously healthy Caucasian adults who developed pan-ante...