Searchable abstracts of presentations at key conferences in endocrinology

ea0032s8.2 | Action of glucocorticoids on bone | ECE2013

Osteoporosis: now and the future

Hofbauer Lorenz C

Osteoporosis is an emerging medical and socioeconomic problem leading to fragility fractures, loss of mobility, chronic pain and cost to the individual and society. Diagnosis is often established only after fracture, although modern techniques exist to make the diagnosis early on where specific therapy is possible. Apart from calcium and vitamin D supplementation and lifestyle counseling, bisphosphonates have become the mainstay of therapy. However, long-term adherence with bi...

ea0031pl5 | British Thyroid Association Pitt-Rivers Lecture | SFEBES2013

BTA_Pitt Rivers Lecture

Bianco Antonio C

A C Bianco is a professor of medicine and Chief of the Division of Endocrinology, Diabetes and Metabolism at the University of Miami Miller School of Medicine. Dr A C Bianco obtained his MD, PhD and clinical training in internal medicine and endocrinology in Sao Paulo, Brazil. His work has established the importance of the local control of thyroid hormone activation/inactivation via deiodination, as well as fundamental cellular and molecular properties of the deiodinases (D1, ...

ea0029s9.1 | The risk and benefits of tight glycaemic control | ICEECE2012

What do type 2 diabetes outcome trials tell us about the CV risks and benefits of intensive glycaemic control

Gerstein Hertzel C.

Diabetes is a strong risk factor for cardiovascular (CV) events, and large epidemiologic studies have repeatedly shown that higher fasting or post-load glucose levels predict a higher incidence of CV events regardless of whether or not diabetes is present. In the UKPDS, targeting near-normal fasting glucose levels in newly diagnosed diabetes with a strategy starting with basal insulin or sulfonylurea reduced the 20-year risk of myocardial infarction and mortality by 15% and 13...

ea0029s23.2 | Advances in regulation of aldosterone synthesis | ICEECE2012

Extra-adrenal aldosterone biosynthesis

Gomez-Sanchez C.

Aldosterone (aldo) concentrations in the brain and heart are slightly lower, but parallel those in the plasma. Plasma, heart and urine aldosterone continue to be detected in very small amounts in adrenalectomized (ADX) rats, however the concentrations of aldosterone in the brain, though very low, are higher than plasma levels in ADX rats. StAR protein and all of the steroidogenic enzymes necessary for the synthesis of aldosterone are expressed in the central nervous system (CN...

ea0029s38.2 | Craniopharyngioma: Hypothalamic complications | ICEECE2012

Hypothalamic disorders in Clinical practice; relevance to clinical practice

Thompson C J

Craniopharyngioma (CP) is associated with considerably higher mortality and morbidity than pituitary adenomas. The tumours are rare, but present a considerable management challenge. In addition to the endocrine and mass effects which are common to all tumours arising from the region of the pituitary fossa, the site, size, and sometimes the treatment of CP, dictate that the endocrinologist must also manage hypothalamic complications. Endocrinologists are aware of the high frequ...

ea0029mte9 | (1) | ICEECE2012

Diagnosis and management of SIADH

Thompson C. J.

Hyponatraemia is the commonest electrolyte abnormality in clinical practice; epidemiological data would suggest that SIAD is the commonest cause of hyponatraemia, and it is particularly important in patients undergoing neurosurgery, in whom SIAD is common. Recent data has shown that even mild hyponatraemia (plasma sodium 125–135 mmol/l) is associated with gait instability, falls, fractures, osteoporosis and increased mortality. This has led to the recognition that correct...

ea0029p153 | Bone & Osteoporosis | ICEECE2012

Comparaison of serum PTH concentrations obtained with a second and a third generation assay in a cohort of hemodialysis patients according to the KDIGO guidelines

Laruelle E. , Massart C.

Introduction: PTH concentrations obtained with the second generation (2G) assays may vary widely according cross-reactivities against 7–84 PTH fragments. 1–84 bio-intact PTH is only measured with a third generation (3G) assay.Objective: To evaluate whether the results found with a 3G method improve the classification of dialysis patients according to the KDIGO recommendations.Patients and methods: We studied the PTH value...

ea0029p365 | Clinical case reports - Pituitary/Adrenal | ICEECE2012

Giant cystic pheochromocytoma in an asymptomatic man

Dimarakis V. , Tsentidis C.

Introduction: Cystic adrenal incidentalomas are relatively rare. Large cystic pheochromocytomas are extremely rare and there are few reports of them being clinically silent.Case presentation: We report the case of a 57-years-old man, who was admitted to our clinic for evaluation of a large cystic lesion that was found ultrasonographicaly in a typical check-up. We ordered a CT that revealed a giant right adrenal cyst (91.3×96.8×92.1 mm) with thi...

ea0029p400 | Clinical case reports - Thyroid/Others | ICEECE2012

New diabetic emergency; acute rhabdomyolysis complicating hyperglycemic hyperosmolar coma successful management and insight into pathogenesis

Vaz C. , Chaudhuri A.

We describe a case of severe rhabdomyolysis(peak CK 48897 μ/ml and massive myoglobinuria) complicating hyperglycemic hyperosmolar coma. A 57y/o M with DM2 on metformin presented with polyuria, polydipsia, weakness and confusion. On admission he had GCS E2M3V1 no signs of trauma or infection. Na 137 mEq/l K 4.8 mEq/l HCO3 22 mEq/l Cl 93 mEq/l BUN 116 mg/dl Cr 3.2 mg/dl glucose 1710 mg/dl pH 7.22 ketones +small, Mg 5.2 mg/dl P 3.3 mg/dl Ca 9.6 mg/dl TSH 1.47 &#95...