Endocrine Abstracts

Tracheomalasia is extremely rare condition in Graves’ disease and may result in pneumomediastium with fistular formation from longstanding compression by a large goiter. There is no report that Graves’ disease combined with tracheomalasia and pneumomediastinum. A 24-year-old woman presented with abdominal pain, diarrhea and fever. On physical examination, a large goiter was detected on her anterior neck. Computed tomography of chest showed large amount of air in ante...

Diabetic peripheral neuropathy (DPN) is a most common complication of diabetes mellitus. Patients with DPN have chronic, painful symptoms that disrupt sleep, depressed mood and can lead to diminish quality of life. We evaluated clinical characteristics of diabetic peripheral neuropathy in past and present in KoreaWe performed the study to determine the prevalence and to understand the clinical characteristics of diabetic peripheral neuropathy in Koreans ...

We describe a case of aggressive pituitary adenoma with atypical biological behavior treated with surgery radiation & chemotherapy. A 46 y/o F presented with nausea & acute vision loss R>L,with no symptoms of amenorrhea, hypothyroidism or hypoadrenalism. Brain MRI showed 4.7×3.6×3.6 cm pituitary macroadenoma with mass effect on optic chiasm, cavernous sinus extension, internal carotid artery encasement, extension into R foramen ovale, orbital apex, spheno...

Acute stressors can active the reproductive function depending on estrogen priming. Corticotropin-releasing hormone (CRH) has been implicated as mediator of stress-induced effects on hypothalamus–pituitary–gonadal axis (HPG), acting in the limbic system, paraventricular nucleus and noradrenergic (NA) neurons. Antalarmin and astressin2-B are selective CRH-R1 and CRH-R2 antagonists, respectively. We investigated the mediation of CRH-R1 and/or CRH-R2 receptors and of lo...

Introduction: Infertility investigations include uterine–ovarian ultrasound. The incidental finding of a tumor in a young female might associate a potential severe prognosis in otherwise completely asymptomatic patient.Aim: We present a case of a young female with an accidentally discovered ovarian tumor.Case report: S.M. 35-year female patient is admitted for infertility. Her family and personal medical history is irrelevant....

We have previously shown that in pancreatic ductal epithelial cells, the expression of the water channel aquaporin-1 is under the control of the oxysterol receptor liver X receptor β. The aim of the present study was to investigate water balance in mice lacking each LXR isoform.Given free access to water, LXRβ−/− mice demonstrated an abnormal daily excretion of highly diluted urine, polyuria, with increased water intake compared to ...

We describe the course of a now 24y/o M with congenital hypopituitarism, severe micropenis, cryptorchidism, hypoplastic testes, hypospadiasis and pulmonic stenosis. He presented with neonatal hypoglycemia. MRI showed small anterior pituitary and ectopic posterior pituitary near tuberous cinereum. Pulmonic stenosis detected after auscultation of a murmur, was mild grade on echo. Free T4 1 ng/dl (1–2.5) TSH 6.7 μU/ml (0.2–6) glucagon stimulation for GH ...

Introduction: Transsphenoidal surgery (TSS) currently presents treatment of choice for Cushing’s disease (CD). Dependent on tumor size, remission rates after initial TSS range from 66 to 94%. In ACTH-secreting pituitary macroadenomas, remission rates are reported to be lower. Visible adenomas on preoperative MRI or intraoperatively and neurosurgical expertise might contribute to successful TSS.Design: A retrospective, single center analysis in 51 CD...

Objective: In the marmoset (Callithrix jacchus) the LH is functionally replaced by the chorionic gonadotropin (CG). However, disparate to the human LH/hCG system, marmoset CG is expressed in both, the pituitary and in the placenta. Previously, we could show the presence of a tissue-specific promoter system in the marmoset. Alternative promoters, as well as different first exons, either a pituitary or a novel placenta specific one, are being employed to direct tissue spe...

The human adrenal gland develops from around 4 weeks gestation and undergoes distinct changes throughout pre- and post-natal life. Defects in these processes can cause adrenal hypoplasia and result in adrenal insufficiency. Adrenal hypoplasia can be: i) secondary to abnormal pituitary function, ACTH synthesis or splicing; ii) the result of ACTH resistance (familial glucocorticoid deficiency; triple A syndrome); or iii) due to a primary defect in adrenal development itself (pri...