Searchable abstracts of presentations at key conferences in endocrinology

ea0029p693 | Diabetes | ICEECE2012

Variations in insulin daily dose and weight with continuous subcutaneous insulin infusion therapy

Belo S. , Esteves C. , Pereira M. , Neves C. , Carvalho D.

Introduction: Intensive diabetes type 1 management can be achieved either with multiple daily insulin injection therapy or with continuous subcutaneous insulin infusion (CSII). The former is becoming increasingly popular do to its positive effects on glycemic control.Objectives: Evaluate the evolution of total daily insulin dose (TDID) and weight on patients with CSII.Methods: Patients with CSII of our department were included. Dat...

ea0029p1385 | Pituitary Clinical | ICEECE2012

Markers of disease activity correlate with cephalometric parameters in acromegalic patients

Carvalho A. , Pinho T. , Pinto J. , Santos A. , Carvalho D.

Introduction: Acromegaly, a rare disorder resulting of tumor GH excess, is frequently associated with prognathism and facial dysmorphia. Characteristics and mechanisms responsible for the malocclusion and the craniofacial changes in acromegalic patients (ACR) are not clarified.Aims: To evaluate the craniofacial changes in an acromegalic group.Methods: We observed 59 individuals, 33 with ACR and 26 controls with nonfunctioning pitui...

ea0026p612 | Clinical case reports | ECE2011

Iatrogenic hypoadrenalism: a case report

Mesquita J , Varela A , Magalhaes A , Correia F , Carvalho D

Introduction: Psoriasis is a chronic skin disease with a prevalence of 0.6 to 4.8%. Among the possible treatments, we highlight topic corticosteroids that can cause not only different local side effects (skin fragility and atrophy, striae, purpura, acne, telangiectasia, hypertrichosis) but also systemic side effects, including diabetes mellitus (DM), hypertension (HT), Cushing’s syndrome and hypothalamic–pituitary–adrenal (HHA) axis suppression.<p class="abs...

ea0011p612 | Neuroendocrinology and behaviour | ECE2006

Positive correlation between AcroQol and SF-36 and negative with BDI in sample of 60 acromegalics

Abreu M , Carvalho D , Vinha E , Webb S , Medina JL

Quality of Life (QoL) is a very important issue in the management of a chronic disease like acromegaly. Recently the AcroQol questionnaire was developed to evaluate the QoL in different acromegalic populations. We decided to compare the scores of AcroQol and 2 other different questionnaires: one related to general well-being (SF-36) and the other to evaluate depression (BDI). We preformed a cross-sectional evaluation of a sample of 60 Portuguese acromegalics, 20 men and 40 wom...

ea0029p100 | Adrenal cortex | ICEECE2012

Exogenous corticosteroids: guilty or innocent?

Matos M. , Freitas P. , Belo S. , Frazao J. , Pimenta T. , Guimaraes S. , Carvalho D.

Introduction: The association between autoimmune diseases, including systemic lupus erythematosus (SLE), and endogenous hypercortisolism is rare. The latter is usually misinterpreted as iatrogenic in the case of patients taking exogenous systemic corticosteroid therapy. The excess endogenous glucocorticoids may play an important role in suppressing autoimmune activity. Similarly, the abrupt resolution of endogenous hypercortisolism may lead to a rebound worsening of autoimmuni...

ea0029p398 | Clinical case reports - Pituitary/Adrenal | ICEECE2012

Endocrine hypertension due to primary aldosteronism

Rodrigues P. , Mesquita J. , Souto S. , Belo S. , Morgado P. , Varela A. , Castedo J. , Magalhaes , Carvalho D.

Introduction: Primary aldosteronism (PA) is currently believed to be the most frequent form of secondary endocrine hypertension, accounting for 5–10% of all hypertensive patients. After confirming the diagnosis, adrenal venous sampling (AVS) is considered the most accurate means of distinguishing between unilateral and bilateral adrenal disease.Case report: Female patient, 36 years-old, referred to an Endocrinology appointment in May 2009 due to lef...

ea0029p718 | Diabetes | ICEECE2012

Gender differences in metabolic outcomes of continuous subcutaneous insulin infusion therapy

Esteves C. , Neves M. , Belo S. , Pereira M. , Sousa Z. , Carvalho D.

Introduction: The continuous subcutaneous insulin infusion (CSII) is an alternative to multiple daily injection therapy in type 1 diabetes and its use is increasingly common due to the beneficial effects on the glycemic control of the patient.Aims: To find differences on outcomes of CSII therapy between genders. Patients and methods: Patients on CSII therapy in our department were included in the study and we recorded outcomes regarding the following set...

ea0029p873 | Endocrine tumours and neoplasia | ICEECE2012

Hypoglycemia by insulinoma: for the purposes of a case

Jorge G. , Nogueira C. , Esteves C. , Neves C. , Queiros J. , Oliveira M. , Pardal J. , Carvalho D.

Clinical caseIntroduction: Insulinoma is a rare disorder with an estimated incidence of 1 case per 250 000 people per year.Case report: 37 years old female, with a history of irritable bowel syndrome, dyslipidemia and kidney stones. In December 2010, she developed a headache, dizziness and visual disturbances, predominantly in the evening and amnesia for some of the episodes. Initially interpreted as peripheral vertiginous syndrome, because of recurrence...

ea0029p1363 | Pituitary Clinical | ICEECE2012

Familial isolated pituitary adenoma: review of four families

Belo S. , Mesquita J. , Nogueira C. , Magalhaes A. , Basto M. , Pereira J. , Carvalho D.

Introduction: Pituitary adenomas are frequent brain tumors, with prevalence of about 1:1000. Most occur sporadically. The familial forms represent 5% of cases. These can be found associated with other endocrine neoplasia (MEN 1, Carney complex, MEN 4) or as a clinical isolated entity – FIPA. This is characterized by the presence of pituitary tumors in two or more family members, in the absence of features of other endocrine syndromes. AIP gene mutation, which may or may n...

ea0026p213 | Pituitary | ECE2011

Hypothalamic tumor in a patient with Pendred syndrome

Giestas A , Almeida M , Teixeira S , Maia A , Azevedo T , Vaz D , Carvalho A , Carvalho R

Introduction: Pendred syndrome is a rare autosomal recessive disease and the classic triad is congenital sensorineural hearing impairment, goiter and impaired iodine organification with abnormal perchlorate discharge test, but hypothalamic tumors are not a feature of this syndrome.Case report: We report a case of a 32-year-old female with Pendred syndrome confirmed by genetic testing and perchlorate discharge test, with goiter, hypothyroidism treated wit...