Searchable abstracts of presentations at key conferences in endocrinology

ea0026p476 | Thyroid cancer | ECE2011

Failure to supress TSH level in a thyroid cancer patient; a case report

Gedik Arzu , Yilmaz Merve , Gumus Tugba , Calan Mehmet , Soyturk Mujde , Comlekci Abdurrahman

TSH supression therapy with thyroid hormone is a mainstay of thyroid cancer treatment. Effectiveness of thyroid hormone therapy may be disrupted by nonadherence of the patient, interfering drugs, foods and intestinal disorders. We here present a case of papillary thyroid cancer with unsuccessful supression therapy.Case: A 38 year old woman, underwent total thyroidectomy for euthyroid multinodular goitre, with a pathological diagnosis of papillary thyroid...

ea0020p41 | Adrenal | ECE2009

Prospective evaluation of metabolic and anthropometric parameters in non-functioning adrenal adenomas

Yener Serkan , Ertilav Senem , Comlekci Abdurrahman , Secil Mustafa , Akinci Baris , Demir Tevfik , Yesil Sena

Adrenal adenomas are characterised with metabolic disturbances. The aim of this study is to demonstrate the changes in some metabolic and anthropometric parameters after 24 months follow up in subjects with non-functioning adrenal adenomas.Subjects referred between 2001 and 2008 for the evaluation of adrenal tumours were included. Computed tomography (CT) was the initial radiological intervention. Initial hormonal evaluation included 1 mg or 2 day 2 mg d...

ea0020p47 | Adrenal | ECE2009

Carotid intima media thickness is increased and associated with morning cortisol in subjects with non-functioning adrenal incidentaloma

Yener Serkan , Genc Sinan , Akinci Baris , Seci Mustafa , Demir Tevfik , Comlekci Abdurrahman , Ertilav Senem , Yesil Sena

Data regarding cardiovascular risk in subjects with non-functioning adrenal adenoma is limited. The aim of this study is to investigate carotid intima media thickness (IMT) as a robust indicator of atherosclerosis in subjects with AI.Of 49 subjects without findings of hypercortisolism or other adrenal gland disorders, 34 BMI-unmatched controls (C) and 18 BMI-matched controls (BC) were enrolled. Participants underwent hormonal evaluation including morning...

ea0020p53 | Adrenal | ECE2009

Prospective evaluation of tumour size and hormone secretion in adrenal incidentalomas

Yener Serkan , Ertilav Senem , Secil Mustafa , Akinci Baris , Demir Tevfik , Comlekci Abdurrahman , Yesil Sena

Increased use and improved technology of imaging procedures have led to increased recognition of adrenal incidentalomas. The aim of this study is to evaluate the natural course of benign adrenal tumours in terms of tumour growth and hormone secretion.Subjects referred between 2001 and 2008 for the evaluation of adrenal tumours were included. Computed tomography (CT) was the initial radiological intervention. Initial hormonal evaluation included 1 mg or 2...

ea0020p402 | Diabetes and Cardiovascular | ECE2009

C-reactive protein level early after starting standard treatment of diabetic foot infection is associated with amputation risk

Akinci Baris , Yener Serkan , Yesil Sena , Yapar Nur , Kucukyavas Yasin , Comlekci Abdurrahman , Eraslan Sevinc , Bayraktar Firat

Prediction of amputation would aid clinicians in the management of the diabetic foot infections. We aimed to assess the predictability of baseline and early post-treatment levels of acute phase reactants on the outcome of patients with diabetic foot infections.In this study, we included patients with infected diabetic foot ulcers who were hospitalized in Dokuz Eylul University Hospital between January 2003 and January 2008, of which data were collected p...

ea0020p426 | Diabetes and Cardiovascular | ECE2009

The effect of creatinine clearance on the short-term outcome of neuropathic diabetic foot ulcers

Akinci Baris , Yesil Sena , Bayraktar Firat , Kucukyavas Yasin , Yener Serkan , Comlekci Abdurrahman , Eraslan Sevinc

Introduction: Reduced creatinine clearance is related to an increased risk of diabetic foot ulcer development. Wound healing has been reported to be worse in diabetic patients with impaired kidney functions than general diabetic population. This study aimed to investigate the effect of creatinine clearance on the short term outcome of neuropathic diabetic foot ulcers.Materials and methods: Data from 147 neuropathic diabetic foot ulcer episodes were inclu...

ea0016p192 | Diabetes and cardiovascular diseases | ECE2008

Endothelin-1 is correlated with TGF-β1 but not with glycemic control in normotensive subjects with type 2 diabetes

Yener Serkan , Akan Pinar , Comlekci Abdurrahman , Akinci Baris , Bayraktar Firat , Yesil Sena

Objectives: Endothelial dysfunction contributes to the development of atherosclerosis in diabetic subjects. Endothelin-1 (ET-1) is an endothelium derived vasoconstrictor. It has been shown that ET-1 levels are increased in a variety of situations such as diabetes, hypertension and obesity. Transforming growth factor beta1 (TGF-β1) is an important cytokine for the development of renal injury in type 2 diabetic patients and associated with hyperglycemia and insulin resistan...

ea0016p697 | Thyroid | ECE2008

Clinical features of TRAB negative Graves disease: a prospective study

Yener Serkan , Bayrakci Nergiz , Demir Tevfik , Bayraktar Firat , Comlekci Abdurrahman , Yesil Sena

Objective: It is well-established that hyperthyroidism of Graves disease is caused by generation of TSH-receptor stimulating autoantibodies. However, in some patients TRAB titers may be in normal levels. The rate and the burden of TRAB negative disease vary between studies. In this study, we compared the clinical and laboratory parameters of 170 patients (85 TRAB positive and 85 TRAB negative) that were diagnosed to have Graves disease in our department....

ea0016p699 | Thyroid | ECE2008

Thymic hyperplasia presenting as a neck mass in Graves' disease

Yener Serkan , Secil Mustafa , Kocdor Mehmet Ali , Ozdogan Ozhan , Comlekci Abdurrahman , Yesil Sena

Introduction: Thymic hyperplasia is a rare manifestation of Graves disease. In this report, we describe a female with Graves’ disease and a neck mass that was associated with thymic hyperplasia.Case report: A 28-year-old woman was referred to our division for the evaluation of palpitations. Thyroid function tests were associated with thyrotoxicosis. Thyroid receptor antibody (TRAb) was found to be 22.3 U/l (positive: >14 U/l). Sonography showed ...

ea0014p289 | (1) | ECE2007

The effects of subclinical hypothyroidism and replacement therapy on paraoxonase-1 (PON-1) and common carotis intima media thickness

Kebapcilar Levent , Comlekci Abdurrahman , Tuncel Pinar , Solak Ahmet , Secil Mustafa , Gencel Omur , Yesil Sena

The mechanism of atherosclerosis in patients with subclinical hypothyroidism (sHT), which has been partly attributed to lipid abnormalities, is still controversial. There is substantial evidence that ox-LDL plays an important role during the atherosclerosis process and paraoxonase-1 (PON-1) significantly inhibits generation of lipid peroxidation and thus plays a role in against atherosclerosis. The aim of the study was evaluate qualitative changes in lipoprotein metabolism, hs...