Searchable abstracts of presentations at key conferences in endocrinology

ea0032p676 | Male reproduction | ECE2013

Two unconventional risk factors for major adverse cardiovascular events in subjects with sexual dysfunction: low education and reported partner's hypoactive sexual desire in comparison with conventional risk factors

Rastrelli Giulia , Corona Giovanni , Daphne Fisher Alessandra , Mannucci Edoardo , Maggi Mario

Introduction: The classification of subjects as low or high cardiovascular (CV) risk is usually performed by risk engines, based upon multivariate prediction algorithms. However, their accuracy in predicting major adverse CV events (MACE) is lower in high-risk populations, since they take into account only conventional risk factors.Aim: To evaluate the accuracy of Progetto Cuore risk engine in predicting MACE in subjects with erectile dysfunction (ED), a...

ea0032p677 | Male reproduction | ECE2013

‘It takes two to tango’: the relational domain in a cohort of subjects with erectile dysfunction (ED)

Boddi Valentina , Rastrelli Giulia , Corona Giovanni , Daphne Fisher Alessandra , Forti Gianni , Maggi Mario

Introduction: The relational domain of erectile dysfunction (ED) is difficult to investigate in a clinical setting. We developed and validated SIEDY, a 13-item structured interview, which assesses, beside the organic (Scale1) and intra-psychic (Scale 3) domains, also the relation one (Scale 2). We previously established a pathological threshold for SIEDY Scale 1 and 3.Aim: To identify a pathological threshold of SIEDY Scale 2.Metho...

ea0026p138 | Male reproduction | ECE2011

Perceived ejaculate volume reduction in subjects with erectile dysfunction: psycho-biological correlates

Corona Giovanni , Boddi Valentina , Gacci Mauro , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: The disorders of orgasm/ejaculation include premature ejaculation, delayed ejaculation and perceived ejaculate volume reduction (PEVR). To explore the specific associations of PEVR in subjects with erectile dysfunction (ED).Methods: A consecutive series of 3141 subjects (mean age 51.6±13.1 years old) was studied. Among these, 71 have been excluded because they underwent prostate surgery. Different clinical and biochemical factors were ...

ea0026p139 | Male reproduction | ECE2011

Perceived reduced sleep-related erections in subjects with erectile dysfunction: psycho-biological correlates

Corona Giovanni , Rastrelli Giulia , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Perceived reduced sleep-related erections (PR-SREs), along with erectile dysfunction (ED) and hypoactive sexual desire, have been recently recognized as the most important symptoms characterizing late onset hypogonadism in community-dwelling European men. However, the clinical correlates of PR-SREs have not been thoroughly investigated. The aim of this study is to evaluate the psychobiological correlates of PR-SREs in a large series of subjects consulting for ED....

ea0026p556 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Is metabolic syndrome a useless category in subjects with high cardiovascular risk? Results from a cohort study in men with erectile dysfunction

Corona Giovanni , Monami Matteo , Rastrelli Giulia , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Although several studies have demonstrated that MetS is associated with a twofold increase in the risk of cardiovascular (CV) diseases, this risk does not appear to be greater than the sum of risks associated with each of its individual components. To determine the association of men with ED and individual components of MetS and their subsequent relationship to cardiovascular (CV) risk, and, more specifically whether the sum of the MetS components is greater than...

ea0026p557 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Prolactin levels independently predict major cardiovascular events in patients with erectile dysfunction

Corona Giovanni , Rastrelli Giulia , Boddi Valentina , Monami Matteo , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: We previously reported that in subjects consulting for sexual dysfunction lower PRL plasma levels were associated with worse lipid and glycemic profile, as well as with a higher prevalence of metabolic syndrome and arteriogenic erectile dysfunction (ED). To assess possible associations between PRL levels and incident major cardiovascular events (MACE) in subjects with ED.Methods: This is an observational prospective cohort study evaluating ...

ea0026p558 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Body mass index regulates hypogonadism-associated CV risk: results from a cohort of subjects with erectile dysfunction

Corona Giovanni , Rastrelli Giulia , Monami Matteo , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Obesity is an independent cardiovascular (CV) risk factor. Testosterone (T) is inversely related to body mass index (BMI) in males. There is substantial evidence suggesting that low T could play a role as a moderator of CV mortality in men, and so this study is designed to assess the possible interaction between T and obesity in predicting major cardiovascular events (MACE) in a sample of subjects with erectile dysfunction.Methods: This is ...

ea0026p559 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Severe depressive symptoms and cardiovascular risk in subjects with erectile dysfunction

Bandini Elisa , Fisher Alessandra , Corona Giovanni , Ricca Valdo , Monami Matteo , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Erectile dysfunction (ED) and mood depression are often associated and both are correlated with an increased risk of cardiovascular morbidity and mortality. The aim of the present study is to explore biological and clinical correlates of depressive symptomatology in a sample of men consulting for sexual dysfunction and to verify possible associations between depressive symptoms and incidence of major cardiovascular events (MACE).Methods: A ...

ea0026p560 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Priapus is happier with Venus than with Bacchus

Corona Giovanni , Boddi Valentina , Monami Matteo , Fisher Alessandra , Bandini Elisa , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: The relationship between alcohol consumption and erectile function is still not completely clarified. Aims of the present study are to explore a number of biological and clinical correlates of alcohol consumption in a sample of men consulting for sexual dysfunction, and to verify possible associations with the incidence of major adverse cardiovascular events (MACEs).Methods: A consecutive series of 1956 (mean age 55±11.9 years old) att...

ea0026p694 | Diabetes complications | ECE2011

Type 2 diabetes mellitus and testosterone: a meta-analysis study

Corona Giovanni , Monami Matteo , Rastrelli Giulia , Aversa Antonio , Lenzi Andrea , Forti Gianni , Mannucci Edordo , Maggi Mario

Introduction: Type 2 diabetes mellitus (T2DM) is often associated with male hypogonadism. The role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified. To systematically analyse the relationship between androgen levels and T2DM by reviewing and meta-analyzing available prospective and cross-sectional studies. In addition, a specific meta-analysis on the metabolic effects of TRT in available randomised clinical trials (RCTs) was also performed.</...