Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep760 | Thyroid | ECE2021

Graves’ Disease after COVID-19

Moreno Tirado Antonio , Paloma González Lázaro , Contreras Pascual Cristina , Montalban Mendez Cristina , Maria Zhao Montero Benítez , Florentino Del Val Zaballos

IntroductionGraves’ Disease is an autoimmune syndrome that include hyperthyroidism, goiter, thyroid eye disease, and occasionally, a dermopathy called pretibial or localized myxedema. As each autoinmune ailment to develop in sufferers with genetic susceptibility after a certain environmental exposure (infection, stress…). COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Since the out...

ea0077lb33 | Late Breaking | SFEBES2021

Complex management of unilateral post-Covid-19 adrenal haemorrhage during pregnancy

Yousuf Quratulain , Elhassan Yasir S , Arlt Wiebke , Jehanzeb Qazi , Krishnasamy Senthil-Kumar , Ronchi Cristina L

Background: Management of large indeterminate adrenal masses detected during pregnancy is challenging due to the risk of malignancy and the obstetric risks of surgical intervention. The spectrum of endocrine-related complications of Covid-19 is expanding. We present a case that highlights the challenging management of a large adrenal mass during pregnancy and draws attention to a rare complication of Covid-19.Case description: 26 yr-old lady presented wi...

ea0081oc8.4 | Oral Communications 8: Calcium and Bone | ECE2022

Is the “rebound phenomenon” following Denosumab discontinuation a risk factor for Zoledronic acid acute phase adverse reactions?

Zampogna Marta , Grassi Giorgia , Ghielmetti Alberto , Palmieri Serena , Arosio Maura , Vainicher Cristina Eller

Background: Zoledronic acid (ZOL) administration may cause acute phase adverse reactions (APR), which manifest with fever, malaise, bone and muscular pain, headache and/or gastrointestinal disturbances. Previous data suggest that high N-terminal propeptide of type 1 collagen (P1NP) and low 25, OH-vitaminD (VitD) levels are associated with higher incidence of APR, while the previous use of bisphosphonates is a protective factor. Lately, ZOL has been frequently used to mitigate ...

ea0081p23 | Adrenal and Cardiovascular Endocrinology | ECE2022

Characterization of cytological assessments of adrenal lesions: A 12-year single center experience

Cristina Carasel Ana Maria , Juhlin C Christofer , Calissendorff Jan , Falhammar Henrik

Background: The accuracy of the radiological and laboratory findings used to investigate adrenal masses are not optimal and therefore additional investigation methods, such as fine needle aspiration (FNA) are sometimes needed. Different methods are used for obtaining FNA such as endoscopic ultrasound (EUS), transabdominal ultrasound and computerized tomography (CT)-guided biopsy.Methods: Using a search function incorporated in our institutional pathology...

ea0081p539 | Adrenal and Cardiovascular Endocrinology | ECE2022

Hypertension of adrenal origin - a never-ending story

Popa Miruna Maria , Cristina Pascu Raluca , Lucian Pavel Mihai , Malinici Elisabeta Andreea , Sirbu Anca , Simona Fica

Background: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors characterized by a high degree of variability and unpredictability. Coexistence of PPGLs and adrenocortical adenomas is an uncommon occurrence that can further complicate the clinical course. Objective: We describe the diagnostic and management challenges of a patient with a history of surgically removed pheochromocytoma, presenting with symptoms of catecholamine exce...

ea0081p558 | Calcium and Bone | ECE2022

Clinical and biochemical response to Burosumab treatment in two patients with X-linked hypophosfatemic rickets and tertiary hyperparathyroidism

Ghielmetti Alberto , Zampogna Marta , Palmieri Serena , Grassi Giorgia , Rosa Caruso Maria , Arosio Maura , Vainicher Cristina Eller

Introduction: in X-linked hypophosfatemic rickets (XLH) mutations of PHEX lead to elevated FGF-23 levels. Phosphate salts and calcitriol represented the only treatment option. Tertiary hyperparathyroidism (THPT) is a complication of XLH worsening the clinical features and constituting a contraindication to conventional treatment. Burosumab, a monoclonal antibody anti-FGF23, was recently approved in XLH. No data about Burosumab treatment in patients with XLH and THPT are availa...

ea0081ep81 | Adrenal and Cardiovascular Endocrinology | ECE2022

Percutaneous ethanol ablation of large adrenal tumor

Nebreda Inmaculada Venegas , Zunzunegui Nerea Egana , Ortega Cristina Elias , Achucarro Ane Amilibia , Arrieta Alfredo Yoldi

Introduction: Percutaneous ablation has been used over the years for the minimally invasive treatment of liver, kidney, thyroid and, although less frequent, adrenal cysts. We describe the case of a young patient with a large adrenal cyst treated with ethanol ablation, avoiding adrenalectomy.Clinical case: We present a 32-year-old woman who is referred to Endocrinology due to a 10 cm adrenal incidental finding in an MRI performed due to disc herniation. A...

ea0081ep115 | Adrenal and Cardiovascular Endocrinology | ECE2022

Paraneoplastic Cushing’s syndrome in metastatic poorly differentiated carcinoma of the kidney

Ghenoiu Sandra , Constantin Teodor , Serban Costel Daniel , Capatina Cristina , Poiana Catalina

Introduction: Paraneoplastic CushingÂ’s syndrome is attributed to ectopic ACTH release from a non-pituitary tumor. The lung is frequently the primary site of the underlying neoplasm but sometimes, in cases of advanced metastatic disease, determining the origin may be challenging.Case presentation: A70-year-old man was reffered to our centre for generalised bone pain, lethargy, and important weight loss in the last six months. Before admission, a cont...

ea0081ep418 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

New-onset diabetes after transplantation (NODAT). A case report

Contreras Pascual Cristina , Gonzalez Lazaro Paloma , Moreno Tirado Antonio , Montero Benitez Maria Zhao , Alvarez Lopez Susana

New-onset diabetes after transplantation (NODAT) is a serious complication after a solid organ transplantation. It has been reported to occur in 4% to 25% of renal transplant recipients, 2.5% to 25% of liver transplant recipients, 40% to 60% of hepatitis C virus (HCV) infection and 2% to 53% of all solid organ transplantations. The diagnosis is performed using unmodified criteria for diagnosing diabetes in the general population and risk factors are the commonly recognized fac...

ea0081ep563 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diabetic ketoacidosis in pregnant women with type 1 DM and Covid 19

Cornejo Dominguez Jesus Manuel , Barea Almudena Lara , Gavira Isabel Maria Mateo , Tinoco Cristina Lopez

Introduction: Diabetes is a recognized risk factor for the development of complications in COVID-19 infection, with an increased incidence of ketoacidosis observed in patients admitted to hospital.Case Reports: We present the case of a patient with type 1 DM complicated by diabetic retinopathy and unplanned pregnancy (pregestational Hba1c 9.1%). In follow-up during pregnancy: progression of retinopathy and fetal renal pyeloectasia in morphological ultras...