Searchable abstracts of presentations at key conferences in endocrinology

ea0029n26 | (1) | ICEECE2012

Evaluation of self management and diabetes education newly diagnosed with Type 2 diabetic patients in Mongolia

Ya Enkhjargal , Tserendagva D , Altaisaikhan Kh , Davaalkham D , Sergelenchimeg S

Introduction: Educating patients about diabetes plays a pivotal role in encouraging people to changing lifestyle and supporting them to improve the quality of life, and actively responsibile for self control of their condition.Objective: To evaluate self management after receiving diabetes education for newly diagnosed Type 2 diabetes in Mongolia.Methods: The cross-sectional survey was conducted from May and October 2011. At Diabet...

ea0029p210 | Calcium & Vitamin D metabolism | ICEECE2012

Longitudinal changes in serum 25-hydroxyvitamin D levels of older persons during 6 and 13 years of follow-up

van Schoor N. , Knol D. , Deeg D. , Heijboer A. , Lips P.

Background: Vitamin D deficiency is very common in older persons. It is not clear how serum 25-hydroxyvitamin D (25(OH)D) levels change during aging.Objective: To examine longitudinal changes in serum 25(OH)D levels in two representative cohorts of Dutch older persons during 6 and 13 years of follow-up, respectively.Methods: Data of the Longitudinal Aging Study Amsterdam (LASA) were used, an ongoing cohort study in older persons. T...

ea0029p257 | Calcium & Vitamin D metabolism | ICEECE2012

Identification of a novel mutation in the calcium sensing receptor gene in FHH

O'Cathail M. , Slattery D. , Hussain T. , O'Halloran D.

IntroductionFamilial hypocalciuric hypercalcemia (FHH) is an autosomal dominant trait comprising hypercalcemia, hypophosphatemia and an unusually low renal clearance of calcium. The vast majority of FHH is caused by loss-of-function mutations in the gene CASR, which codes for the calcium-sensing receptor (CASR). CASR is a G-protein coupled membrane receptor expressed in the parathyroid glands and the kidneys, among other tissues. It is generally asymptom...

ea0029p367 | Clinical case reports - Pituitary/Adrenal | ICEECE2012

Rhabdomyolysis and myopathy in Addison’s disease: is there a connection?

Katalinic D. , Solter M. , Planinc D. , Plestina S.

Introduction: Rhabdomyolysis coexisting with Addison’s disease is a rare condition and the mechanism is not clearly defined. We report a patient presenting with sever rhabdomyolysis which resolved after steroid replacement therapy.Case report: A 33-year-old man without accompanying comorbidity, presented with progressive myopathy and fatigue. He was hypotensive (RR 90/70), hypovolemic with hyponatremia (125 mmol/l, range 137–146), elevated seru...

ea0029p437 | Clinical case reports - Thyroid/Others | ICEECE2012

Hypogonadism with subsequent multi-organ involvement: a mystery solved

Mohandas C. , Barnes D. , Harrington D. , Haq M.

A 53-year-old gentleman was seen following a recent diagnosis of type 2 diabetes in May 2009. He had suffered a subarachnoid haemorrhage in 1993 and remained under the local tertiary centre after developing secondary hypogonadism treated with testosterone replacement. The cause had never been established.The patient had previously been diagnosed with seronegative HLA B27 arthropathy and in December 2008 was admitted with acute cardiac failure and atrial ...

ea0029p559 | Diabetes | ICEECE2012

Low testosterone is associated with decreased expression of glut-4 and hexokinase 2 in muscle of the testicular feminised mouse

McLaren D , Kelly D , Akhtar S , Channer K , Jones T

Testosterone deficiency is a common in men with type two diabetes (T2D). We have shown testosterone replacement therapy (TRT) improves insulin resistance and glycaemic control. The mechanisms by which testosterone mediates this action are unknown but may be due to a combination of effects on muscle, liver and adipose tissues. This study investigates the expression of Glut4 and HK2, (two key proteins involved in insulin sensitivity) in muscle tissue of the testicular feminised ...

ea0029p619 | Diabetes | ICEECE2012

Cardiac dyssynchrony as a pathophysiological mechanism of heart failure development and progression in type 2 diabetic patients

Lopin D. , Lopina N. , Rodionova J. , Vlasenco M. , Volkov D.

Objectives: Diabetes mellitus (DM) is an independent predictor of new onset heart failure (HF) and adverse outcomes among patients with already existing HF. However mechanisms leading to impaired cardiac performance due to DM are still unclear.The purpose of investigation was to assess the influence of cardiac dyssynchrony (DYS) on systolic and diastolic function in patient with type 2 diabetes mellitus (T2DM) with concomitant stable coronary artery dise...

ea0029p930 | Female Reproduction | ICEECE2012

The prevalence of endometrial hyperplasia and endometrial cancer in Danish women with PCOS or hyperandrogenism

Ravn P. , Glintborg D. , Andersen M. , Holm N. , Scledermann D.

Objective: PCOS may be associated with an increased risk of endometrial hyperplasia (EH) and endometrial cancer (EC), but substantial evidence remains to be established. We investigated the prevalence of EH and EC in a well-characterized group of women with PCOS and/or clinical/biochemical hyperandrogenism.Design: Retrospective, trans-sectional study.Setting: Out-patient clinic at the Departments of Endocrinology and Gynecology, Od...

ea0029p1659 | Thyroid (non-cancer) | ICEECE2012

The syndromes of thyroid autoimmunity among patients with antiphospholipid syndrome

Jelic S. , Stojanovic L. , Marisavljevic D. , Popovic-Kuzmanovic D.

Background: Literature data regarding the prevalence of the syndromes of thyroid autoimmunity (AIT) in antiphospholipid syndrome (APS) are rather limited. However, quite frequently it is hypothesized on common pathophysiologic mechanisms underlining these disorders.Objectives: The aim of this investigation was to evaluate the frequency of disorders of thyroid function and occurrence of anti-thyroid antibodies (ATAs) among patients with antiphospholipid s...

ea0029p1679 | Thyroid (non-cancer) | ICEECE2012

The concept of ultrasonographic thyroid pattern: re-evaluation after 10 years

Peretianu D. , Poiana C. , Carsote M. , Staicu D. , Clodeanu A.

Aim: To re-analyze the concept of echographic thyroid patterns (ETP) and clinical diagnostic in thyroidology, proposed 10 years ago.Material/method: i) Between 1996 and 2012, >25 000 thyroid ultrasound, linear probes, 7.5 MHz. ii) Description – eight ETP: pattern 0 – lack of thyroid, 1 – hypoechogenous pseudonodular; 2 – hypoecogen homogenous; 3 – micronodular hypoechogenous; 4 – macro (> 10 mm; ±micro) nodular;...