Endocrine Abstracts

Objectives: To investigate how the immune associations (IA) may have significance for diagnosis or therapy in thyroiditis.Material and method: Patients: A. ‘Classical’ Hashimoto thyroiditis (hyper-ATPO-emia, HT) =1092, B. thyroiditis with isolated hyper-ATG-emia, with normal ATPO (T-ATG) =61, C. thyroiditis ‘sero-negative’ (normal ATPO and ATG, pathology diagnosis) =5, D. idiopathic myxedema (hypothyroidism, no A, B,C) =70; E. control...

Aim and objectives: To investigate the rapport between the level of thyroid function, through blood level of TSH, both at onset, and in evolution and the level of antithyroperoxydase antibodies (ATPO) and antithyroglobuline antibodies (ATG) in Hashimoto thyroiditis and related diseases.Material and method: Diagnosis: a. ATPO >34 μ/ml = Hashimoto thyroiditis (HT); b. ATPO=normal with high ATG = thyroiditis with only hyper-ATG (T-ATG); c. hypothyr...

Aim: Analyzing the evolution of thyroid function in thyroiditis and related disease during 1–15 years.Materials and methods: A) Diagnostic: Hashimoto thyroiditis (HT): i) antithyroperoxydase antibodies (ATPO) cut-off 34. ii) If ATPO=normal (N), was considered thyroiditis with only antithyroglobuline antibodies (T-ATG); iii) idiopathic mixedema (IM): hypothyroidism, no ATPO, no ATG, no TRAB.B) Patients: i) HT: 1092; T-ATG: 61; ...

Introduction: We investigated short-term influence of thyroxin replacement therapy on blood pressure (BP) and cardiovascular status in patients with first identified primary hypothyroidism (PH) and earlier diagnosed arterial hypertension (AH).Methods: 52 patients with PH and AH were observed twice: prior to replacement therapy and after reaching euthyroid status. All patients underwent daily BP monitoring, echocardiography, and high frequency ultrasound ...

Aim, Objectives: Conceptualizing new data related to type and level of autoantibodies in thyroiditis Hashimoto, Graves-Basedow disease and releated conditions.Material: ###1. Adoption the integrative concepts of immune network (Nobel Prize, 1984) for immune thyroid diseases. 2. Searching on “www.ncbi.nlm.nih.gov/pubmed” for papers with keywords: thyroid autoantibody, thyroiditis (~2500 papers). 4. New (auto)-antibodies (and antigens/epitopes) f...

We have previously reported, that cultured female- derived human Osteoblats (hObs) responded to DT56a (Femarelle). Since the skeletal protective effects of estrogens are not discernible in diabetic women, we sought to test the effects of DT56a on hObs grown in high glucose concentration in the growth medium (HG) as compared to estradiol-17β (E2). We used the stimulation of creatine kinase specific activity (CK), and 3[H] thymidine incorporation into ...

Background: Idiopathic intracranial hypertension (IIH) can rarely be associated with underlying endocrine disorders such as Cushing’s syndrome, hyperthyroidism or with administration of thyroxin or growth hormone. We describe a case of acute adrenal deficiency presented along with IIH.Case history: A 24-year-old Caucasian female (body mass index 21 kg/m2) presented with nausea, vomiting and collapse. She had several months of generalised ...

Background: The influence of the hypothalamic pituitary adrenal axis is not limited to reproduction. Female sex steroids influence learning and memory and the neurobiology of brain regions involved in memory processing such as the hippocampus. Pregnancy allows overriding of regulatory feedback loops leading to elevation of endogenous serum hormone levels, depending on concentration; oestradiol can be either neurologically protective or toxic. This investigation aims to increas...

Case: In April 2008, a 68-year-old male was referred to the endocrine clinic with symptoms of hyperthyroidism and was prescribed carbimazole 20 mg daily. A week later, he developed sudden onset dizziness, together with reduced hearing in his left ear and associated tinnitus. Similar symptoms developed in his right ear shortly thereafter. Seven weeks after starting carbimazole, he attended the ENT outpatient clinic with severe vertigo, tinnitus and bilateral hearing loss. Otosc...

Background: Hypothyroidism occurs in 2.5% of pregnancies. We are using a database follow up system for pregnant women with hypothyroidism in our hospital. All the women with hypothyroidism are added on a database system at their first visit to the antenatal clinic. Any adjustment to thyroxine was made on the first visit after checking TFT and repeat TFTs were done at 20 and 30-weeks gestation. Any adjustments to thyroxine were communicated to them via letter. The aim of this s...