Searchable abstracts of presentations at key conferences in endocrinology

ea0012p77 | Pituitary | SFE2006

An unusual case presentation of acromegaly

Nathan Y , Russell-Jones D

A 35year old man presented to the cardiology clinic with effort dyspnoea, palpitations and light-headedness. He had just returned from a 6 month “round the world’ trip during which he had suffered a diarrhoeal illness. An echocardiogram performed in Bangkok revealed left ventricular dilatation but no other significant changes. A diagnosis of possible myocarditis was entertained and he was treated with 2.5 mg of Ramipril and 75 mg of Aspirin. When seen in the cardiolo...

ea0011p806 | Thyroid | ECE2006

Maternal iodine deficiency alters learning ability and emotional state of the progeny

Sarishvili A , Lazrishvili N , Metreveli D

Deficient production of thyroid hormones in maternal organism may have a drastic impact on brain development of the offsprings. Among the people originated from the regions with essential deficiency of iodine in foodstuff there is a high chance for prevalence of mental retardation and neurological cretinism with all possible complications.The present study analyses changes in emotional state (open field testing), learning ability and memory processes (ma...

ea0010p5 | Clinical case reports/Governance | SFE2005

Autoimmune Addison’s disease in identical twins

Zachariah S , Russell-Jones D

Autoimmune adrenal insufficiency may be familial or non familial. We report a case of identical female twins, both with Addison’s disease and detectable antibodies to adrenal cortex.Case report: Twin A at age of 27 developed Addison’s disease and hypothyroidism. She was found to be positive for anti-adrenal antibodies, anti-thyroid antibodies and intrinsic factor auto antibodies. Therefore Twin B was tested for the same auto antibodies and was ...

ea0010p78 | Steroids to include Cushing's | SFE2005

Induction of pigmentation up regulates ERalpha and aromatase in epidermal melanocytes and melanoma cells

Meskiri A , Thornton M , Tobin D

An increase in cutaneous pigmentation during pregnancy is common, but usually regresses following parturition. Epidemiological studies also suggest that females may have a sex survival advantage in cases of malignant melanoma. However, estrogen action in melanoma remains contradictory. We have recently demonstrated that both epidermal and hair follicle melanocytes express ERα and ERβ however, estrogen action in human pigment cell biology remains poorly characterised....

ea0010p88 | Steroids to include Cushing's | SFE2005

Non-genomic effects of the glucocorticoid receptor - the effect of glucocorticoids on activation of c-src and PKB/Akt

Kayahara M , Berry A , Ray D

Glucocorticoids (Gc) are potent anti-inflammatory agents, but their clinical use is limited by their significant side effects. The effects of glucocorticoids are mediated by the cytosolic glucocorticoid receptor (GR), which regulates transcription by transactivation or transrepression. Independent of these genomic effects of the GR are other, very rapid non-genomic effects.The glucocorticoid receptor forms a complex with hsp90, FKBP51, FKBP52 and cyp40 i...

ea0008p50 | Endocrine Tumours and Neoplasia | SFE2004

Dramatic response with medical treatment of an extensively invasive 'giant' prolactinoma with cabergoline

Muralidhara KS , Ahmed A , Darko D

A previously well 75 year old man, presented with progressive right sided weakness and ataxia of three months duration that had worsened considerably during the previous 3 weeks. On examination, there was right hemiparesis, marked ataxia, sluggish pupillary responses and an extensive right sided visual field deficit confirmed by formal visual field testing. CT brain large suprasellar mass extending into pituitary fossa. MRI brain confirmed it to be a large pituitary macroadeno...

ea0007p268 | Clinical case reports | BES2004

The pituitary lesion that escaped the knife

Heald A , Hughes D , Buckler H

A 38 year old lady presented at 30 weeks gestation with a 3 week history of headaches and 5 day history of blurring of vision, worse in the left eye. Visual field testing revealed a bitemporal hemianopia. MRI scan of the pituitary showed appearances typical of a macroadenoma which was lobulated in appearance with suprasellar extension (max height 13mm) and compression of the optic chiasm. Endocrine tests indicated that thyroxine was low for the 3rd trimester (79nmol/l), with f...

ea0006dp11 | Diabetes, metabolism and cardiovascular | SFE2003

A Prospective Audit of Triple Therapy in Type 2 Patients

James A , Levy D , Davison R

We conducted a prospective audit of triple therapy in type 2 patients (Dec01 to Dec02). 51 patients on maximal Metformin and sulphonylurea had a Glitazone added. 11 patients were lost to follow up. The remaining 40 patients, 23 Male, 17 Female, mean age 51years (35-66), diabetes mean duration 8.5 years (2-16) had a mean BMI of 33.8 (range 22-47). Mean baselineHbA1C was 9.6% (7.3-12.3%).Parameters measured were blood pressure, height, weight BMI, full blo...

ea0004s10 | Ageing and cellular senescence | SFE2002

Extending Lifespan

Bartke A , Dominici F , Turyn D

Complex interactions between aging and the endocrine system include an important role of hormones in mediating effects of genotype on longevity. In Caenorhabditis elegans and Drosophila melanogaster, striking extension of life span can be produced by targeted disruption (knock out, KO) of genes that control signaling pathways homologous to insulin/insulin-like growth factor signaling in mammals. In the mouse, Mus musculus, longevity is greatly increased by spontaneous and expe...

ea0003oc40 | Hormone Action | BES2002

RU486, the glucocorticoid receptor (GR) antagonist, recruits NCoR, but not SRC-1: Explaining type II antagonism

Stevens A , Garside H , Ray D

The glucocorticoid receptor antagonist, RU486, binds to the glucocorticoid receptor (GR) with high affinity, and allows both nuclear localisation and also DNA binding. However, the DNA bound GR does not activate target gene transcription. This suggests that the ligand-binding domain of the GR is required to interpret agonist and antagonist ligands, and transmit those signals to the basal transcriptional machinery. Adaptor proteins play an important role in transducing the effe...