Endocrine Abstracts

Background: IGF1R targeting emerged in recent years as a promising therapeutic approach in prostate cancer (PCa). The insulin receptor (IR) shares high structure homology with the IGF1R and activates similar signaling cascades. In recent studies we have shown that insulin’s mitogenic activities in PCa cells are mediated via the IR. Given the central role of IR in regulation of metabolism, most anti-IGF1R therapeutic strategies were designed to specifically inhibit IGF1R, ...

Objective: To evaluate the associations among body mass index, weight perception and cardiovascular risk factors in male career US firefighters.Design: The present cross-sectional study was nested within a federally-funded multicenter, prospective cohort investigation of cardio-respiratory fitness (CRF), health and employment outcomes among career firefighters.Subjects: Seven hundred and sixty-eight male career firefighters from tw...

There is compelling evidence that shiftworkers are at risk of developing metabolic disturbances, diabetes and obesity as a result of disruption to circadian rhythms, but the mechanisms by which this may occur are not clear. The Bmal1 null mouse, which lacks both central and peripheral tissue rhythms, was used in this study to address the role of circadian rhythmicity in metabolic homeostasis.Male Bmal1 null mice and wild-type litter mates (2 month...

Congenital combined pituitary hormone deficiency (CCPHD) is a rare disease.Although most of them are growth hormone deficient, growth retardation is not always the presenting symptom\. There is no normative data in children younger than 3 years regarding dose and frequency with rhGH treatment. The objective was to evaluate the timing of growth retardation and the first and second year growth response to rhGH compared to the mathematical growth prediction...

Symptom of tall is manifestation of many endocrine and genetic diseases. Their early detection is necessary for timely therapy, for improvement of disease state and prognosis for a disease. 47 XYY syndrome is one of frequent occurrence diseases that are accompanied with primary tall. Materials and methods. Patient L., 12 years old, was under our observation. Chief complaint – tall height. Intracranial hypertension, delay in speech development and gross motor delay were re...

Objective: Macroprolactinaemia is the phenomenon of forming immunoglobulins (Igs) against prolactin (PRL). The Ig–PRL complex has an increased half-life resulting in elevated levels of immunoreactivity in most PRL immunoassays without having any significance. Identifying macroprolactinaemia-induced hyperprolactinaemia is essential in order to prevent unnecessary testing and treatment. This study is to establish the combined intra- and inter-individual variability in macro...

Introduction: Pituitary adenomas with cavernous sinus involvement (CSI) are associated with serious clinical sequelae but are often incompletely excised during surgery. Contradictory viewpoints exist regarding management of residual tumors in the cavernous sinus with some authors suggesting use of adjuvant radiotherapy post-operatively for long term tumor control. But radiotherapy has been associated with hypopituitarism and increased mortality due to cerebrovascular causes. W...

Introduction: Diagnosis and exact localization of minute adenomas in Cushing disease (CD) can be problematic, leading to unsuccessful trans-sphenoidal pituitary explorations (TSS). In addition to the well established inferior petrosal sinus sampling (IPS) first described in 1989, direct intraoperative cavernous sinus sampling (CSS) and in 1993, preoperative CSS with very small catheters, have been published (1,2). The experience in relatively small series had been promising, b...

Background: The so called ‘big-big’ prolactin, also known as macroprolactin is formed by prolactin-immunoglobulin complexes, is considered to be biologically inactive, but may cause elevation of serum prolactin (Prl) concentrations measured by standard assays. In women presenting with oligo- and/or amenorrhoea the cause of menstrual irregularity needs to be explained even in the setting of concomitant macroprolactinaemia. We have therefore attempted to assess the pre...

Background: Measurements of TSH, free tetraiodothyronin (FT4) and triiodothyronin (FT3) are essential to achieve assessment of thyroid function. Luminescent Oxygen Channelling Immunoassays (LOCI) have recently been developed for the measurement of biomarkers of thyroid function. Such homogeneous immunoassays allow a faster delivery of the results. The aim of our study were therefore to determine the reference values for LOCI TSH, FT4 and FT<sub...