Endocrine Abstracts

Introduction: Bilateral exophtalmoses is common at Graves’ disease diagnosis, but context and clinical abnormalities lead sometimes to consider other diagnosis.Case report: A 52-year-old man had a previous history of pulmonary MALT lymphoma in complete remission and Hashimoto’s thyroiditis, which were diagnosed simultaneously 6 years before. He presented recently with hyperthyroidism (TSH <0.001 mUI/l; T4=25 pmol/l) after 2 month...

Introduction: The correlation between lipid profile changes & overt hypothyroidism is well established. Overt hypothyroidism is associated with increased risk for cardiovascular disease (CVD) as indicated by hypertension, elevated lipids levels, hypercholesterolemia, and particularly increased low-density lipoprotein cholesterol (LDL-C) levels. However, lipid profile alterations in primary and subclinical hypothyroidism are controversial. There are hardly any studies from ...

Background: The most important aspect in the diagnostic approach of thyroid nodule is identifying the malignancy. Elastography is a newly technique that measures the elasticity of tissue, after applying a external force, standardized control. US elastography is currently used in differentiation of malignant from benign lesions.Material, Method: This prospective study included 69 patients, mean age 50.08±12.43 years, 67 females and 2 men, with thyroi...

Background: Conventional ultrasound remains the most used imaging evaluation in case of a thyroid nodule.Material, method: This prospective study included 69 patients (107 nodules). Conventional and Doppler ultrasound was performed with a HITACHI EUB 7500 HV machine with 6–13 MHz variable frequency linear probe, with Doppler software. All patients underwent surgery after complete evaluation.Postsurgical histopathological exam was performed. We analy...

Introduction: The Birt–Hogg–Dube syndrome (BHDS) is a rare autosomal dominant genodermatosis characterised by presence of at least one of the following: benign skin fibrofolliculomas, lung cysts with recurrent pneumothoraces or renal tumours. The phenotypic constellation is due to heterozygous germline mutations of the tumour suppressor gene – FLCN, located on 17p11.2, encoding a 579 aminoacid protein termed folliculin. Case reports have described endocrine tumo...

Introduction: The two major long-acting somatostatin analogues (SSA) available on the European market for the treatment of neuroendocrine tumours and acromegaly are Somatuline Autogel (SA) and Sandostatin LAR (LAR). The aim of this study was to gain nurses’ insights on the use and ease of administration of SSA devices, including Somatuline Autogel new device (SA-ND), in Europe and the US.Methods/design: Seventy-seven qualified nurses with ≥3 S...

Background: Dopamine agonists (DA) are used as the first-line trearment in patients with macroprolactinomas. Late resistant to DA(cabergoline) therapy may occur. Patient with resistant macroprolactinoma may end up receiving a relative high dose of DA. These patients should be advised to take up radiotherapy option as earlier as possible to avoid the need of high dose dopamine agonist. We present a 63-year-old man who presented in 1999 with visual loss,due to giant macroprolact...

Introduction: It is well known fact that central lipid stores are related to glucose metabolism impairment. Standard anthropologic methods for measuring lipid stores centralisation are waist, waist to hip ratio and waist to height ratio. Still, often these markers fail to relate to difference in glucose metabolism between equally obese patients.Method: We analysed relation between waist line radius and subcutaneous adipose tissue thickness, determent wit...

In 2007 a genome wide association study linked SNPs in intron 1 of FTO with an increased body mass index. Individuals with the ‘risk’ allele are on average 3 kg heavier than those with the ‘protective’ allele. Furthermore, those with the ‘risk’ allele have demonstrated greater energy intake. Mouse models of FTO have been generated including a conditional overexpression allele of FTO, which has 2 additional copies of FTO (FTO-4). These mice have in...

Introduction: It is supposed that primary hyperparathyroidism (pHPT) during pregnancy is associated with significant maternal and fetal risks as high as 67 and 80%, respectively. The very few case reports published referred mainly to unrecognized pHPT or diagnosed during pregnancy. We report the case of a woman with known asymptomatic pHPT who became pregnant.Case-report: A woman, 29 years, was diagnosed with pHPT a year before becoming pregnant; her bio...