Endocrine Abstracts

Introduction: Bronchial Carcinoids are rare neoplasms originating from the diffuse neuroendrocrine system. Surgery is the only effective therapy but may not be feasible due to metastases. Available therapy may control symptoms but not tumor bulk. Everolimus has shown promising results, however patients may develop resistance. Previous studies demonstrated that Everolimus reduces viability of NCI-H720 (Atypical Carcinoid) but not of NCI-H727 cells (Typical Carcinoid). In order ...

IntroductionMetabolic compensation of patients with diabetes mellitus (DM) depends on psychosocial well-being and healthy lifestyle, both of which were influenced by the national lockdown in spring 2020 due to the SARS-CoV-2 pandemic. The goal of our study was to analyze the impact of Swiss national lockdown (17.3.2020–24.4.2020) on compensation of DM as expressed by the level of HbA1c.MethodsWe performe...

Objective: Clarify mechanisms determining thyroid homeostasis during pregnancy at hypothalamic-pituitary level.Methods: Retrospective analysis of 251 pregnant women. 220/251 euthyroid without thyroxine therapy (Group 1), 31/251 thyroidectomized under thyroxine replacement therapy (Group 2). Patients under thyroxine replacement therapy with a TSH between 0.4 and 4.0 were included in the study. Patients with combined T3/T4 therapy were excluded.<p clas...

Objectives: During the Covid-19 pandemic caused by the severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2), vaccination has been widely adopted. Both SARS-CoV-2 infection and Covid-19 vaccines have been associated with several thyroid disorders. We studied the risk of Thyroid Eye Disease (TED) following Covid-19 vaccination.Methods: This self-controlled-case-series study, validated model in assessing vaccine safety, included 98 consecutive patie...

Background: Obesity is a major public health issue frequently associated with increased complication rates after elective general surgery. Previous reports on complications after thyroid surgery in obese patients were performed on selected cohorts. In this study, we sought to explore the relationship between Body Mass Index (BMI) and postoperative morbidity after thyroid surgery in a large cohort of consecutive patients.Materials and Methods: A single-ce...

Thyroid hormones (TH) are responsible for maintaining metabolism. Its concentrations are fundamental during pregnancy and the first days of life, and its imbalance can generate early and late repercussions for the newborn.Objectives: This study evaluates the relationship between maternal thyroid disease history impact on newborns and infants admitted to the semi-intensive care unit.Materials and methods: Data were collected from a ...

Patients with adrenal insufficiency show higher mortality than in the general population, mainly due to non-physiological daily glucocorticoid overexposure and to inadequate cortisol exposure during stress-related events and illness. The aim of the current study is to compare the impact of 10 years of conventional glucocorticoid (GC) replacement treatment and dual-release hydrocortisone (DR-HC), on anthropometric, metabolic, cardiovascular and bone outcomes in treatment-na&#23...

Several studies suggest that vitamin D (VitD) has beneficial effects on male reproduction. Analysis of the correlation between VitD and sperm quality parameters demonstrated that it has a significant impact on sperm motility, partially suggesting a relationship between higher serum testosterone levels and VitD levels. In females, vitD deficiency is associated with adverse pregnancy outcomes and metabolic complications in PCOS. However, there is still no concrete evidence to su...

Background: Pituitary stalk interruption syndrome (PSIS) is a rare congenital condition characterised by the triad of thin or absent pituitary stalk, hypoplasia of the adenohypophysis, and ectopic neurohypophysis. PSIS has multifactorial aetiology with highly heterogenous clinical manifestations, usually diagnosed in early infancy or childhood. There have been previous reports of untreated panhypopituitarism diagnosed in adulthood, indicating preservation of some pituitary fun...

Background: Molecular analysis of thyroid fine-needle aspiration biopsy (FNA) was proposed to improve indeterminate nodules management. However, sensibility and specificity as well as the cost of molecular diagnostics require to be improved to increase their cost-effectiveness for medical practice setting. Raman spectroscopy (RS) demonstrated ability in separating benign from malignant thyroid lesions in surgically removed tissues, based on specific RS profile. This study aime...