Searchable abstracts of presentations at key conferences in endocrinology

ea0038p3 | Bone | SFEBES2015

Reduction in daily hydrocortisone dose in adrenal insufficiency improves significantly bone mineral density – results from a 2-years prospective trial

Schulz Julia , Koetz Kathrin , Ventz Manfred , Diederich Sven , Quinkler Marcus

Introduction: Patients with primary adrenal insufficiency (PAI) and patients with congenital adrenal hyperplasia (CAH) receive life-long glucocorticoid (GC) replacement therapy. Today daily GC doses are still higher than the reported adrenal cortisol production rate, and are not able to reproduce the physiological secretion pattern. This might result in long-term morbidities such as osteoporosis. Until now no prospective trial was performed investigating the long-term effect o...

ea0035p44 | Adrenal cortex | ECE2014

Bone mineral density does not decrease in patients with adrenal insufficiency on a low daily glucocorticoid dose over a 2 year period

Schulz Julia , Koetz Kathrin , Ventz Manfred , Diederich Sven , Quinkler Marcus

Introduction: Patients with primary adrenal insufficiency (PAI) and patients with congenital adrenal hyperplasia (CAH) receive glucocorticoid replacement therapy, which might cause osteoporosis.Objective: i) Is bone mineral density (BMD) depending on the height of the daily glucocorticoid dose? ii) Is BMD decreasing over a 2-year period of glucocorticoid replacement therapy?Methods: Prospective, longitudinal study including 56 pati...

ea0025p9 | Bone | SFEBES2011

Bone mineral density in patients with primary adrenal insufficiency compared to patients with congenital adrenal hyperplasia

Koetz Kathrin , Ventz Manfred , Diederich Sven , Quinkler Marcus

Introduction: Patients with primary adrenal insufficiency (Addison’s disease) and patients with congenital adrenal hyperplasia (CAH) still tend to receive more glucococorticoids than the normal endogenous production in healthy subjects. CAH patients start glucocorticoid treatment usually with diagnosis in their early childhood, whereas Addison’s patients have a later onset of their disease and start of their treatment.Objective: To compare pati...

ea0020p584 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Feedback inhibition of prednisolone on vasopressin (AVP) secretion but preserved renal water reabsorption after thirsting point to an AVP independent antidiuretic action

Ufer Friederike , Mai Knut , Diederich Sven , Pedersen Erling , Pfeiffer Andreas , Bahr Volker

Adrenal insufficiency can result in severe hyponatremia due to inappropriate high plasma vasopressin (pAVP). To elucidate the glucocorticoid AVP feedback we monitored thirsting of 12 male volunteers without and after on or five days of prednisolone (30 mg/d). Although prednisolone suppressed pAVP below 0.2 pg/ml the rise in plasma osmolality during thirsting was not influenced by prednisolone. Independent of exogenous glucocorticoid thirsting resulted in higher urine osmolalit...

ea0016p23 | Adrenal | ECE2008

Effects of free fatty acids on adrenocorticotropin secretion and metabolic glucocorticoid pattern in healthy young women

Mai Knut , Reinecke Franziska , Bobbert Thomas , Andres Janin , Bahr Volker , Wudy Stefan , Hartmann Michaela , Maser-Gluth Christiane , Diederich Sven , Pfeiffer Andreas , Spranger Joachim

Introduction: Free fatty acids (FFAs) affect pituitary function. While no effect of FFAs on ACTH and cortisol seems to exist in men, data in women are somewhat controversial. Therefore, we aimed to assess the effect of an acute increase of circulating FFA levels induced by the infusion of a lipid-heparin infusion on ACTH and cortisol secretion in healthy young women.Methods: Following a 10-h overnight fast 13 healthy female volunteers were investigated i...

ea0016p37 | Adrenal | ECE2008

The German Conn's registry: comorbidities in over 700 patients with primary hyperaldosteronism

Born-Frontsberg Eric , Schirpenbach Caroline , Hahner Stefanie , Beuschlein Felix , Bidlingmaier Martin , Diederich Sven , Lorenz R , Rump Lars , Seufert Jochen , Endres Stefan , Quinkler Marcus , Reincke Martin

Objective: Hypokalemic Conn’s syndrome is a rare disease with a prevalence of 0.5% in unselected hypertensive populations. However, recent studies indicate a higher prevalence of a milder variant of Conn’s syndrome, reaching 10% in some studies. Long term outcome and health care costs of hypo- and normokalemic variants are largely unknown. The National Conn’s Registry is an initiative to create a national database of sufficient epidemiological strength to invest...

ea0016p45 | Adrenal | ECE2008

Renal function in patients with primary aldosteronism: comparison with essential hypertension

Reincke Martin , Schirpenbach Caroline , Hahner Stephanie , Beuschlein Felix , Bidlingmaier Martin , Diederich Sven , Lorenz Reinhard , Rump Lars Christian , Seufert Jochen , Meisinger Christa , Holle Rolf , Quinkler Marcus

Objective: Primary aldosteronism (PA) is associated with vascular end organ damage. We evaluated the newly established German Conn’s Register for evidence of renal impairment and compared the data with renal function from hypertensive subjects from an epidemiologic cohort.Methods: The registry was founded in 2006 and has at present 7 participating centres in 5 locations. Data are entered in a central electronic database. Up to July 2007 555 patients...

ea0022oc4.1 | Adrenals | ECE2010

Subtype differentiation in primary hyperaldosteronism: evaluation of alternative algorithms avoiding a controversial gold standard

Lang Katharina , Hahner Stefanie , Vonend O , Rump L C , Quninkler M , Diederich Sven , Maier Katharina , Beuschlein Felix , Bidlingmaier Martin , Endres S , Engelke C , Kickuth Ralph , Fassnacht Martin , Reincke Martin , Allolio Bruno

Context: Primary aldosteronism (PHA) is the most common cause of secondary hypertension. Distinguishing unilateral (UAH) from bilateral (BAH) and other causes of PHA is one of the greatest challenges in the diagnostic process. Adrenal venous sampling (AVS) is widely considered to be the gold standard for subtype differentiation.Methods: Technical and diagnostic outcome of AVS was analysed retrospectively in 59 patients with PHA who underwent AVS at the U...

ea0016p22 | Adrenal | ECE2008

Free fatty acids affect urinary excretion of androgen precursors thereby linking metabolism and hyperandrogenemia in vivo: results of a randomized, controlled trial

Mai Knut , Bobbert Thomas , Reinecke Franziska , Andres Janin , Bahr Volker , Maser-Gluth Christiane , Wudy Stefan , Hartmann Michaela , Mohlig Matthias , Weickert Martin O , Schulte Heinrich , Diederich Sven , Pfeiffer Andreas , Spranger Joachim

Context: The polycystic ovarian syndrome (PCOS) is characterized by hyperandrogenism and associated with obesity and impaired glucose metabolism. Despite the high prevalence of PCOS and the considerable clinical impact, the precise interplay between metabolism and hyperandrogenemia is not entirely clear. We therefore aimed to analyse the relation between circulating free fatty acids (FFAs) and androgen metabolism in vivo in women.Design and partic...

ea0022s15.2 | Wnt signalling | ECE2010

Wnt-signaling and the metabolic syndrome

Schinner Sven

Wnt-signaling has been discovered as a regulator of adipocyte biology, pancreatic β-cell proliferation and insulin secretion. In addition, this pathway has been implicated in the regulation of aldosterone and cortisol secretion by the adrenal cortex. There is evidence that Wnt-signaling molecules can mediate a crosstalk between adipocytes and endocrine cells like pancreatic β-cells and adrenocortical cells.In addition, the recent genome-wide as...